Human Gene C5AR1 (ENST00000355085.4_4) from GENCODE V47lift37
  Description: complement C5a receptor 1 (from RefSeq NM_001736.4)
Gencode Transcript: ENST00000355085.4_4
Gencode Gene: ENSG00000197405.8_8
Transcript (Including UTRs)
   Position: hg19 chr19:47,813,118-47,825,323 Size: 12,206 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr19:47,813,153-47,824,087 Size: 10,935 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:47,813,118-47,825,323)mRNA (may differ from genome)Protein (350 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: C5AR_HUMAN
DESCRIPTION: RecName: Full=C5a anaphylatoxin chemotactic receptor; Short=C5a-R; Short=C5aR; AltName: CD_antigen=CD88;
FUNCTION: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
SUBUNIT: Interacts with ARRB1 and ARRB2 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
PTM: Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: C5AR1
Diseases sorted by gene-association score: listeria meningitis (2), malaria (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 182.77 RPKM in Whole Blood
Total median expression: 437.41 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.2035-0.234 Picture PostScript Text
3' UTR -343.301236-0.278 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR002234 - Anphylx_rcpt
IPR001274 - C5A_anaphtx_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on P21730
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001856 complement component C5a binding
GO:0004871 signal transducer activity
GO:0004875 complement receptor activity
GO:0004878 complement component C5a receptor activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0000187 activation of MAPK activity
GO:0002430 complement receptor mediated signaling pathway
GO:0006915 apoptotic process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007606 sensory perception of chemical stimulus
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010759 positive regulation of macrophage chemotaxis
GO:0021534 cell proliferation in hindbrain
GO:0030449 regulation of complement activation
GO:0030593 neutrophil chemotaxis
GO:0031100 animal organ regeneration
GO:0032494 response to peptidoglycan
GO:0032496 response to lipopolysaccharide
GO:0038178 complement component C5a signaling pathway
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0043312 neutrophil degranulation
GO:0043524 negative regulation of neuron apoptotic process
GO:0045766 positive regulation of angiogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050830 defense response to Gram-positive bacterium
GO:0050900 leukocyte migration
GO:0060326 cell chemotaxis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090023 positive regulation of neutrophil chemotaxis

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0030667 secretory granule membrane
GO:0031410 cytoplasmic vesicle
GO:0045177 apical part of cell


-  Descriptions from all associated GenBank mRNAs
  BC008982 - Homo sapiens complement component 5a receptor 1, mRNA (cDNA clone MGC:17119 IMAGE:4177114), complete cds.
M62505 - Human C5a anaphylatoxin receptor mRNA, complete cds.
CU679211 - Synthetic construct Homo sapiens gateway clone IMAGE:100017067 5' read C5AR1 mRNA.
DQ894940 - Synthetic construct Homo sapiens clone IMAGE:100009400; FLH179641.01L; RZPDo839A11131D complement component 5a receptor 1 (C5AR1) gene, encodes complete protein.
KJ890794 - Synthetic construct Homo sapiens clone ccsbBroadEn_00188 C5AR1 gene, encodes complete protein.
BT007358 - Homo sapiens complement component 5 receptor 1 (C5a ligand) mRNA, complete cds.
DQ891757 - Synthetic construct clone IMAGE:100004387; FLH179645.01X; RZPDo839A11132D complement component 5a receptor 1 (C5AR1) gene, encodes complete protein.
X57250 - H.sapiens C5aR mRNA for C5 anaphylatoxin receptor.
JD276079 - Sequence 257103 from Patent EP1572962.
JD382034 - Sequence 363058 from Patent EP1572962.
JD391299 - Sequence 372323 from Patent EP1572962.
JD394073 - Sequence 375097 from Patent EP1572962.
JD519028 - Sequence 500052 from Patent EP1572962.
JD106472 - Sequence 87496 from Patent EP1572962.
JD450474 - Sequence 431498 from Patent EP1572962.
JD352170 - Sequence 333194 from Patent EP1572962.
JD533648 - Sequence 514672 from Patent EP1572962.
JD446290 - Sequence 427314 from Patent EP1572962.
JD382220 - Sequence 363244 from Patent EP1572962.
JD319925 - Sequence 300949 from Patent EP1572962.
JD107963 - Sequence 88987 from Patent EP1572962.
JD341991 - Sequence 323015 from Patent EP1572962.
JD159136 - Sequence 140160 from Patent EP1572962.
JD209375 - Sequence 190399 from Patent EP1572962.
JD301464 - Sequence 282488 from Patent EP1572962.
JD112040 - Sequence 93064 from Patent EP1572962.
JD364636 - Sequence 345660 from Patent EP1572962.
JD367065 - Sequence 348089 from Patent EP1572962.
JD523852 - Sequence 504876 from Patent EP1572962.
JD523853 - Sequence 504877 from Patent EP1572962.
JD138989 - Sequence 120013 from Patent EP1572962.
JD506728 - Sequence 487752 from Patent EP1572962.
JD561687 - Sequence 542711 from Patent EP1572962.
JD118585 - Sequence 99609 from Patent EP1572962.
JD341277 - Sequence 322301 from Patent EP1572962.
JD449397 - Sequence 430421 from Patent EP1572962.
JD326547 - Sequence 307571 from Patent EP1572962.
JD393139 - Sequence 374163 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P21730 (Reactome details) participates in the following event(s):

R-HSA-375395 C5a receptor binds C5a anaphylatoxin
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-6798743 Exocytosis of secretory granule membrane proteins
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-977606 Regulation of Complement cascade
R-HSA-418594 G alpha (i) signalling events
R-HSA-6798695 Neutrophil degranulation
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-166658 Complement cascade
R-HSA-388396 GPCR downstream signalling
R-HSA-168249 Innate Immune System
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-168256 Immune System
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: C5AR, C5AR1_HUMAN, C5R1, ENST00000355085.1, ENST00000355085.2, ENST00000355085.3, NM_001736, P21730, uc317yxw.1, uc317yxw.2
UCSC ID: ENST00000355085.4_4
RefSeq Accession: NM_001736.4
Protein: P21730 (aka C5AR_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.