Human Gene CA1 (ENST00000523022.6_8) from GENCODE V47lift37
  Description: carbonic anhydrase 1, transcript variant 5 (from RefSeq NM_001164830.2)
Gencode Transcript: ENST00000523022.6_8
Gencode Gene: ENSG00000133742.14_16
Transcript (Including UTRs)
   Position: hg19 chr8:86,239,837-86,290,342 Size: 50,506 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr8:86,240,789-86,253,864 Size: 13,076 Coding Exon Count: 7 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:86,239,837-86,290,342)mRNA (may differ from genome)Protein (261 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CA1
Diseases sorted by gene-association score: transient global amnesia (8), intracranial abscess (7), central sleep apnea (7), occlusion precerebral artery (6), carotid artery occlusion (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 126.39 RPKM in Colon - Transverse
Total median expression: 148.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.9092-0.162 Picture PostScript Text
3' UTR -182.30952-0.191 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Descriptions from all associated GenBank mRNAs
  M33987 - Human carbonic anhydrase I (CAI) mRNA, complete cds.
EU794595 - Homo sapiens epididymis secretory protein Li 11 (HEL-S-11) mRNA, complete cds.
BC027890 - Homo sapiens carbonic anhydrase I, mRNA (cDNA clone MGC:34628 IMAGE:5222602), complete cds.
GQ891527 - Homo sapiens clone HEL-S-248 epididymis secretory sperm binding protein mRNA, complete cds.
X05014 - Human cDNA for carbonic anhydrase I.
KJ890804 - Synthetic construct Homo sapiens clone ccsbBroadEn_00198 CA1 gene, encodes complete protein.
KR710667 - Synthetic construct Homo sapiens clone CCSBHm_00015514 CA1 (CA1) mRNA, encodes complete protein.
KR710668 - Synthetic construct Homo sapiens clone CCSBHm_00015515 CA1 (CA1) mRNA, encodes complete protein.
CU693312 - Synthetic construct Homo sapiens gateway clone IMAGE:100016918 5' read CA1 mRNA.
DQ890930 - Synthetic construct clone IMAGE:100003560; FLH167612.01X; RZPDo839D0290D carbonic anhydrase I (CA1) gene, encodes complete protein.
DQ894091 - Synthetic construct Homo sapiens clone IMAGE:100008551; FLH167608.01L; RZPDo839D0289D carbonic anhydrase I (CA1) gene, encodes complete protein.
JD185960 - Sequence 166984 from Patent EP1572962.
JD041585 - Sequence 22609 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CA1 , ENST00000523022.1, ENST00000523022.2, ENST00000523022.3, ENST00000523022.4, ENST00000523022.5, hCG_20883 , HEL-S-11 , NM_001164830, uc323xgi.1, uc323xgi.2, V9HWE3, V9HWE3_HUMAN
UCSC ID: ENST00000523022.6_8
RefSeq Accession: NM_001128831.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.