Human Gene CA7 (ENST00000338437.7_4) from GENCODE V47lift37
  Description: carbonic anhydrase 7, transcript variant 1 (from RefSeq NM_005182.3)
Gencode Transcript: ENST00000338437.7_4
Gencode Gene: ENSG00000168748.14_7
Transcript (Including UTRs)
   Position: hg19 chr16:66,878,317-66,888,050 Size: 9,734 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr16:66,878,391-66,887,401 Size: 9,011 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:66,878,317-66,888,050)mRNA (may differ from genome)Protein (264 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CAH7_HUMAN
DESCRIPTION: RecName: Full=Carbonic anhydrase 7; EC=4.2.1.1; AltName: Full=Carbonate dehydratase VII; AltName: Full=Carbonic anhydrase VII; Short=CA-VII;
FUNCTION: Reversible hydration of carbon dioxide.
CATALYTIC ACTIVITY: H(2)CO(3) = CO(2) + H(2)O.
COFACTOR: Zinc.
ENZYME REGULATION: Activated by histamine, L-adrenaline, L- and D- histidine, and L- and D-phenylalanine. Inhibited coumarins, sulfonamide derivatives such as acetazolamide (AZA), by saccharin and Foscarnet (phosphonoformate trisodium salt).
SUBCELLULAR LOCATION: Cytoplasm (Probable).
SIMILARITY: Belongs to the alpha-carbonic anhydrase family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CA7
Diseases sorted by gene-association score: trichosporonosis (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 30.83 RPKM in Colon - Transverse
Total median expression: 81.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.8074-0.484 Picture PostScript Text
3' UTR -239.80649-0.369 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001148 - Carbonic_anhydrase_a
IPR023561 - Carbonic_anhydrase_a-class
IPR018338 - Carbonic_anhydrase_a-class_CS
IPR018438 - Carbonic_anhydrase_CA7

Pfam Domains:
PF00194 - Eukaryotic-type carbonic anhydrase

SCOP Domains:
51069 - Carbonic anhydrase

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3MDZ - X-ray MuPIT 3ML5 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P43166
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0046872 metal ion binding

Biological Process:
GO:0015701 bicarbonate transport
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0032849 positive regulation of cellular pH reduction
GO:2001225 regulation of chloride transport

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AY075019 - Homo sapiens carbonic anhydrase VII mRNA, complete cds.
BC033865 - Homo sapiens carbonic anhydrase VII, mRNA (cDNA clone MGC:45245 IMAGE:5185069), complete cds.
DQ895264 - Synthetic construct Homo sapiens clone IMAGE:100009724; FLH182880.01L; RZPDo839D08139D carbonic anhydrase VII (CA7) gene, encodes complete protein.
EU176243 - Synthetic construct Homo sapiens clone IMAGE:100006429; FLH182887.01X; RZPDo839B08250D carbonic anhydrase VII (CA7) gene, encodes complete protein.
AY075020 - Homo sapiens carbonic anhydrase VII short form mRNA, complete cds.
JD524358 - Sequence 505382 from Patent EP1572962.
JD393096 - Sequence 374120 from Patent EP1572962.
JD200313 - Sequence 181337 from Patent EP1572962.
JD426077 - Sequence 407101 from Patent EP1572962.
JD237010 - Sequence 218034 from Patent EP1572962.
JD071193 - Sequence 52217 from Patent EP1572962.
JD194495 - Sequence 175519 from Patent EP1572962.
JD379422 - Sequence 360446 from Patent EP1572962.
JD335629 - Sequence 316653 from Patent EP1572962.
JD113084 - Sequence 94108 from Patent EP1572962.
JD285921 - Sequence 266945 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P43166 (Reactome details) participates in the following event(s):

R-HSA-1475022 Carbonic anhydrase dehydrates bicarbonate (cytosol)
R-HSA-1475026 Carbonic anhydrase hydrates carbon dioxide (cytosol)
R-HSA-1475029 Reversible hydration of carbon dioxide
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: CAH7_HUMAN, ENST00000338437.1, ENST00000338437.2, ENST00000338437.3, ENST00000338437.4, ENST00000338437.5, ENST00000338437.6, NM_005182, P43166, Q541F0, Q86YU0, uc317val.1, uc317val.2
UCSC ID: ENST00000338437.7_4
RefSeq Accession: NM_005182.3
Protein: P43166 (aka CAH7_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.