ID:CAH9_HUMAN DESCRIPTION: RecName: Full=Carbonic anhydrase 9; EC=4.2.1.1; AltName: Full=Carbonate dehydratase IX; AltName: Full=Carbonic anhydrase IX; Short=CA-IX; Short=CAIX; AltName: Full=Membrane antigen MN; AltName: Full=P54/58N; AltName: Full=Renal cell carcinoma-associated antigen G250; Short=RCC-associated antigen G250; AltName: Full=pMW1; Flags: Precursor; FUNCTION: Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. CATALYTIC ACTIVITY: H(2)CO(3) = CO(2) + H(2)O. COFACTOR: Zinc. ENZYME REGULATION: Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt). BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 6.5; SUBUNIT: Forms oligomers linked by disulfide bonds. SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus. TISSUE SPECIFICITY: Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa. INDUCTION: By hypoxia. PTM: Asn-346 bears high-mannose type glycan structures. SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16790
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001666 response to hypoxia GO:0002009 morphogenesis of an epithelium GO:0015701 bicarbonate transport GO:0033574 response to testosterone GO:0042493 response to drug GO:0046903 secretion GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
