ID:CCG8_HUMAN DESCRIPTION: RecName: Full=Voltage-dependent calcium channel gamma-8 subunit; AltName: Full=Neuronal voltage-gated calcium channel gamma-8 subunit; AltName: Full=Transmembrane AMPAR regulatory protein gamma-8; Short=TARP gamma-8; FUNCTION: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. SUBUNIT: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG7. Interacts with CNIH2 (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. SEQUENCE CAUTION: Sequence=AAK15019.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part; Sequence=AAL50049.1; Type=Frameshift; Positions=Several;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WXS5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006816 calcium ion transport GO:0019226 transmission of nerve impulse GO:0034765 regulation of ion transmembrane transport GO:0070588 calcium ion transmembrane transport GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
