ID:CYBP_HUMAN DESCRIPTION: RecName: Full=Calcyclin-binding protein; Short=CacyBP; Short=hCacyBP; AltName: Full=S100A6-binding protein; AltName: Full=Siah-interacting protein; FUNCTION: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). SUBUNIT: Homodimer. Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner (By similarity). Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated. PTM: Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations. SIMILARITY: Contains 1 CS domain. SIMILARITY: Contains 1 SGS domain. SEQUENCE CAUTION: Sequence=AAG23817.1; Type=Frameshift; Positions=203;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HB71
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007507 heart development GO:0007568 aging GO:0045740 positive regulation of DNA replication GO:0055007 cardiac muscle cell differentiation GO:0060416 response to growth hormone GO:0060548 negative regulation of cell death GO:0071277 cellular response to calcium ion GO:1990830 cellular response to leukemia inhibitory factor
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
