Human Gene CALM3 (ENST00000291295.14_5) from GENCODE V47lift37
  Description: calmodulin 3, transcript variant 1 (from RefSeq NM_005184.4)
Gencode Transcript: ENST00000291295.14_5
Gencode Gene: ENSG00000160014.17_9
Transcript (Including UTRs)
   Position: hg19 chr19:47,104,587-47,114,039 Size: 9,453 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr19:47,104,692-47,112,410 Size: 7,719 Coding Exon Count: 6 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:47,104,587-47,114,039)mRNA (may differ from genome)Protein (149 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CALM3
Diseases sorted by gene-association score: long qt syndrome 1* (200), catecholaminergic polymorphic ventricular tachycardia* (19), otomycosis (16), external ear disease (15), cardiomyopathy, dilated, 1p (12), otitis externa (11), leber congenital amaurosis 2 (11), acute dacryocystitis (10), long qt syndrome 15 (9), deafness, autosomal recessive 44 (8), primary systemic mycosis (8), primary cutaneous amyloidosis (8), hemolytic anemia due to triosephosphate isomerase deficiency (8), sporotrichosis (8), dystonia 24 (7), spontaneous ocular nystagmus (7), gestational choriocarcinoma (5), cardiomyopathy, dilated, 1a (5), cardiac arrest (5), proliferative fasciitis (5), clear cell acanthoma (5), low compliance bladder (4), deafness, autosomal dominant 2a (4), multiple epiphyseal dysplasia (4), long qt syndrome (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 852.22 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 9411.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -49.00105-0.467 Picture PostScript Text
3' UTR -563.701629-0.346 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC006182 - Homo sapiens calmodulin 3 (phosphorylase kinase, delta), mRNA (cDNA clone MGC:715 IMAGE:3528814), complete cds.
JC051455 - Sequence 7 from Patent WO2013153214.
FJ224310 - Homo sapiens epididymis secretory protein Li 72 (HEL-S-72) mRNA, complete cds.
J04046 - Human calmodulin mRNA, complete cds.
BC005137 - Homo sapiens calmodulin 3 (phosphorylase kinase, delta), mRNA (cDNA clone MGC:1447 IMAGE:3504793), complete cds.
JD435651 - Sequence 416675 from Patent EP1572962.
JD126212 - Sequence 107236 from Patent EP1572962.
AK310762 - Homo sapiens cDNA, FLJ17804.
AK295927 - Homo sapiens cDNA FLJ61744 complete cds, highly similar to Calmodulin.
AB384949 - Synthetic construct DNA, clone: pF1KB4445, Homo sapiens CALM3 gene for calmodulin, complete cds, without stop codon, in Flexi system.
BT006855 - Homo sapiens calmodulin 3 (phosphorylase kinase, delta) mRNA, complete cds.
KJ890814 - Synthetic construct Homo sapiens clone ccsbBroadEn_00208 CALM3 gene, encodes complete protein.
KJ905155 - Synthetic construct Homo sapiens clone ccsbBroadEn_14560 CALM3 gene, encodes complete protein.
KJ904428 - Synthetic construct Homo sapiens clone ccsbBroadEn_13822 CALM3-like gene, encodes complete protein.
AK094964 - Homo sapiens cDNA FLJ37645 fis, clone BRHIP2000245.
JD181714 - Sequence 162738 from Patent EP1572962.
JD184028 - Sequence 165052 from Patent EP1572962.
AK124456 - Homo sapiens cDNA FLJ42465 fis, clone BRACE2030096.
JD143647 - Sequence 124671 from Patent EP1572962.
JD387137 - Sequence 368161 from Patent EP1572962.
JD540607 - Sequence 521631 from Patent EP1572962.
JD443664 - Sequence 424688 from Patent EP1572962.
JD070760 - Sequence 51784 from Patent EP1572962.
JD193380 - Sequence 174404 from Patent EP1572962.
JD449855 - Sequence 430879 from Patent EP1572962.
JD149990 - Sequence 131014 from Patent EP1572962.
JD118672 - Sequence 99696 from Patent EP1572962.
JD369379 - Sequence 350403 from Patent EP1572962.
JD109142 - Sequence 90166 from Patent EP1572962.
AL050207 - Homo sapiens mRNA; cDNA DKFZp586F1923 (from clone DKFZp586F1923).
JD095566 - Sequence 76590 from Patent EP1572962.
JD052347 - Sequence 33371 from Patent EP1572962.
JD428153 - Sequence 409177 from Patent EP1572962.
JD263406 - Sequence 244430 from Patent EP1572962.
JD214043 - Sequence 195067 from Patent EP1572962.
JD546469 - Sequence 527493 from Patent EP1572962.
JD122731 - Sequence 103755 from Patent EP1572962.
JD056923 - Sequence 37947 from Patent EP1572962.
JD466464 - Sequence 447488 from Patent EP1572962.
JD223172 - Sequence 204196 from Patent EP1572962.
JD164593 - Sequence 145617 from Patent EP1572962.
JD249053 - Sequence 230077 from Patent EP1572962.
JD152604 - Sequence 133628 from Patent EP1572962.
JD044482 - Sequence 25506 from Patent EP1572962.
JD445379 - Sequence 426403 from Patent EP1572962.
JD329334 - Sequence 310358 from Patent EP1572962.
JD370983 - Sequence 352007 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells
h_pgc1aPathway - Regulation of PGC-1a
h_calcineurinPathway - Effects of calcineurin in Keratinocyte Differentiation
h_nos1Pathway - Nitric Oxide Signaling Pathway
h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling
h_CaCaMPathway - Ca++/ Calmodulin-dependent Protein Kinase Activation
h_bcrPathway - BCR Signaling Pathway
h_gpcrPathway - Signaling Pathway from G-Protein Families
h_tcrPathway - T Cell Receptor Signaling Pathway
h_ndkDynaminPathway - Endocytotic role of NDK, Phosphins and Dynamin
h_Ccr5Pathway - Pertussis toxin-insensitive CCR5 Signaling in Macrophage
h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway
h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells
h_gcrPathway - Corticosteroids and cardioprotection
h_mef2dPathway - Role of MEF2D in T-cell Apoptosis
h_no1Pathway - Actions of Nitric Oxide in the Heart
h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart)
h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells
h_hdacPathway - Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)
h_pyk2Pathway - Links between Pyk2 and Map Kinases

-  Other Names for This Gene
  Alternate Gene Symbols: CALM3 , CALM3_HUMAN, CALML2, CAM3, CAMC, CAMIII, ENST00000291295.1, ENST00000291295.10, ENST00000291295.11, ENST00000291295.12, ENST00000291295.13, ENST00000291295.2, ENST00000291295.3, ENST00000291295.4, ENST00000291295.5, ENST00000291295.6, ENST00000291295.7, ENST00000291295.8, ENST00000291295.9, NM_005184, P02593, P0DP25, P62158, P70667, P99014, Q13942, Q53S29, Q61379, Q61380, Q96HK3, uc317kxi.1, uc317kxi.2
UCSC ID: ENST00000291295.14_5
RefSeq Accession: NM_005184.4

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene CALM3:
cvt (Catecholaminergic Polymorphic Ventricular Tachycardia)
rws (Long QT Syndrome Overview)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.