Human Gene CALML3 (ENST00000315238.3_4) from GENCODE V47lift37
  Description: calmodulin like 3 (from RefSeq NM_005185.4)
Gencode Transcript: ENST00000315238.3_4
Gencode Gene: ENSG00000178363.5_8
Transcript (Including UTRs)
   Position: hg19 chr10:5,566,924-5,568,734 Size: 1,811 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr10:5,567,049-5,567,498 Size: 450 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:5,566,924-5,568,734)mRNA (may differ from genome)Protein (149 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CALL3_HUMAN
DESCRIPTION: RecName: Full=Calmodulin-like protein 3; AltName: Full=CaM-like protein; Short=CLP; AltName: Full=Calmodulin-related protein NB-1;
FUNCTION: May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates.
TISSUE SPECIFICITY: Expressed in normal mammary, prostate, cervical, and epidermal tissues. It is greatly reduced or undetectable in transformed cells.
INDUCTION: By TGFB1.
MISCELLANEOUS: Binds four calcium ions.
SIMILARITY: Belongs to the calmodulin family.
SIMILARITY: Contains 4 EF-hand domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 668.44 RPKM in Esophagus - Mucosa
Total median expression: 1456.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.80125-0.366 Picture PostScript Text
3' UTR -479.601236-0.388 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018248 - EF-hand
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR002048 - EF_hand_Ca-bd

Pfam Domains:
PF00036 - EF hand
PF13202 - EF hand
PF13405 - EF-hand domain
PF13499 - EF-hand domain pair
PF13833 - EF-hand domain pair

SCOP Domains:
63446 - Type I dockerin domain
109998 - Triger factor/SurA peptide-binding domain-like
47473 - EF-hand
82784 - OsmC-like
103647 - TSP type-3 repeat

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1GGZ - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P27482
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Cellular Component:
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  DQ891776 - Synthetic construct clone IMAGE:100004406; FLH179825.01X; RZPDo839C02132D calmodulin-like 3 (CALML3) gene, encodes complete protein.
DQ894960 - Synthetic construct Homo sapiens clone IMAGE:100009420; FLH179821.01L; RZPDo839C02131D calmodulin-like 3 (CALML3) gene, encodes complete protein.
M36707 - Human calmodulin-like processed pseudogene, complete cds.
AK313934 - Homo sapiens cDNA, FLJ94574, Homo sapiens calmodulin-like 3 (CALML3), mRNA.
M58026 - Human NB-1 mRNA, complete cds.
BC031889 - Homo sapiens calmodulin-like 3, mRNA (cDNA clone MGC:30093 IMAGE:4777524), complete cds.
JD290728 - Sequence 271752 from Patent EP1572962.
KJ890815 - Synthetic construct Homo sapiens clone ccsbBroadEn_00209 CALML3 gene, encodes complete protein.
AB590316 - Synthetic construct DNA, clone: pFN21AE1412, Homo sapiens CALML3 gene for calmodulin-like 3, without stop codon, in Flexi system.
JD114291 - Sequence 95315 from Patent EP1572962.
JD279664 - Sequence 260688 from Patent EP1572962.
JD140228 - Sequence 121252 from Patent EP1572962.
JD259872 - Sequence 240896 from Patent EP1572962.
JD260120 - Sequence 241144 from Patent EP1572962.
JD171788 - Sequence 152812 from Patent EP1572962.
JD068105 - Sequence 49129 from Patent EP1572962.
JD538061 - Sequence 519085 from Patent EP1572962.
JD060329 - Sequence 41353 from Patent EP1572962.
JD398577 - Sequence 379601 from Patent EP1572962.
JD530391 - Sequence 511415 from Patent EP1572962.
JD160207 - Sequence 141231 from Patent EP1572962.
JD357747 - Sequence 338771 from Patent EP1572962.
JD249298 - Sequence 230322 from Patent EP1572962.
JD235541 - Sequence 216565 from Patent EP1572962.
JD222103 - Sequence 203127 from Patent EP1572962.
JD350673 - Sequence 331697 from Patent EP1572962.
JD079400 - Sequence 60424 from Patent EP1572962.
JD183571 - Sequence 164595 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R9V6, CALL3_HUMAN, ENST00000315238.1, ENST00000315238.2, NM_005185, P27482, Q5SQI4, uc317ptu.1, uc317ptu.2
UCSC ID: ENST00000315238.3_4
RefSeq Accession: NM_005185.4
Protein: P27482 (aka CALL3_HUMAN or CALL_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.