Human Gene CALML6 (ENST00000307786.8_9) from GENCODE V47lift37
  Description: calmodulin like 6, transcript variant 1 (from RefSeq NM_138705.4)
Gencode Transcript: ENST00000307786.8_9
Gencode Gene: ENSG00000169885.10_11
Transcript (Including UTRs)
   Position: hg19 chr1:1,846,699-1,848,735 Size: 2,037 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr1:1,846,720-1,848,632 Size: 1,913 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:1,846,699-1,848,735)mRNA (may differ from genome)Protein (181 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CALL6_HUMAN
DESCRIPTION: RecName: Full=Calmodulin-like protein 6; AltName: Full=Calglandulin-like protein;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Expressed in prostate, thymus, heart, skeleton muscle, bone marrow and ovary.
SIMILARITY: Belongs to the calmodulin family. Calglandulin subfamily.
SIMILARITY: Contains 4 EF-hand domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.59 RPKM in Muscle - Skeletal
Total median expression: 32.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.6021-0.219 Picture PostScript Text
3' UTR -43.90103-0.426 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR002048 - EF_hand_Ca-bd

Pfam Domains:
PF00036 - EF hand
PF13202 - EF hand
PF13405 - EF-hand domain
PF13499 - EF-hand domain pair
PF13833 - EF-hand domain pair

SCOP Domains:
47473 - EF-hand

ModBase Predicted Comparative 3D Structure on Q8TD86
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0046872 metal ion binding

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AF490905 - Homo sapiens calglandulin-like protein (CALGP) mRNA, complete cds.
AY566229 - Homo sapiens calglandulin-like protein (CAGLP) mRNA, complete cds.
JD209514 - Sequence 190538 from Patent EP1572962.
JD119218 - Sequence 100242 from Patent EP1572962.
JD421014 - Sequence 402038 from Patent EP1572962.
BC053567 - Homo sapiens calmodulin-like 6, mRNA (cDNA clone IMAGE:6203086), with apparent retained intron.
BC160060 - Synthetic construct Homo sapiens clone IMAGE:100063996, MGC:193175 calmodulin-like 6 (CALML6) mRNA, encodes complete protein.
JD361597 - Sequence 342621 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A2A2M3, CAGLP, CALGP, CALL6_HUMAN, ENST00000307786.1, ENST00000307786.2, ENST00000307786.3, ENST00000307786.4, ENST00000307786.5, ENST00000307786.6, ENST00000307786.7, NM_138705, Q6Q2C4, Q8TD86, uc317odp.1, uc317odp.2
UCSC ID: ENST00000307786.8_9
RefSeq Accession: NM_138705.4
Protein: Q8TD86 (aka CALL6_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.