Human Gene CAMK2D (ENST00000511664.6_12) from GENCODE V47lift37
  Description: calcium/calmodulin dependent protein kinase II delta, transcript variant 34 (from RefSeq NM_001396964.1)
Gencode Transcript: ENST00000511664.6_12
Gencode Gene: ENSG00000145349.20_19
Transcript (Including UTRs)
   Position: hg19 chr4:114,372,188-114,682,894 Size: 310,707 Total Exon Count: 21 Strand: -
Coding Region
   Position: hg19 chr4:114,376,911-114,682,224 Size: 305,314 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:114,372,188-114,682,894)mRNA (may differ from genome)Protein (533 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MalacardsMGIPubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: E9PF82_HUMAN
DESCRIPTION: SubName: Full=Calcium/calmodulin-dependent protein kinase type II subunit delta;
SIMILARITY: Contains 1 protein kinase domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CAMK2D
Diseases sorted by gene-association score: dilated cardiomyopathy (8), cardiomyopathy (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.45 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 526.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -328.40670-0.490 Picture PostScript Text
3' UTR -853.403513-0.243 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020636 - Ca/CaM-dep_Ca-dep_prot_Kinase
IPR013543 - Ca/CaM-dep_prot_kinase-assoc
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase
PF08332 - Calcium/calmodulin dependent protein kinase II association domain
PF13474 - SnoaL-like domain
PF14534 - Domain of unknown function (DUF4440)

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
56112 - Protein kinase-like (PK-like)
54427 - NTF2-like

ModBase Predicted Comparative 3D Structure on E9PF82
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004672 protein kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0044325 ion channel binding
GO:0050998 nitric-oxide synthase binding

Biological Process:
GO:0001666 response to hypoxia
GO:0006468 protein phosphorylation
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010649 regulation of cell communication by electrical coupling
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014911 positive regulation of smooth muscle cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030007 cellular potassium ion homeostasis
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0035022 positive regulation of Rac protein signal transduction
GO:0046777 protein autophosphorylation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0055119 relaxation of cardiac muscle
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0086003 cardiac muscle cell contraction
GO:0098901 regulation of cardiac muscle cell action potential
GO:1901897 regulation of relaxation of cardiac muscle
GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO:1903076 regulation of protein localization to plasma membrane

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0032991 macromolecular complex
GO:0034704 calcium channel complex
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK025368 - Homo sapiens cDNA: FLJ21715 fis, clone COL10287, highly similar to AF071569 Homo sapiens multifunctional calcium/calmodulin-dependent protein kinase II delta2 isoform mRNA.
AK294517 - Homo sapiens cDNA FLJ53470 complete cds, highly similar to Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17).
AK055642 - Homo sapiens cDNA FLJ31080 fis, clone HSYRA2001615, highly similar to Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17).
AF071569 - Homo sapiens multifunctional calcium/calmodulin-dependent protein kinase II delta2 isoform mRNA, complete cds.
AB209288 - Homo sapiens mRNA for calcium/calmodulin-dependent protein kinase II delta isoform 1 variant protein.
BC032784 - Homo sapiens calcium/calmodulin-dependent protein kinase II delta, mRNA (cDNA clone MGC:44911 IMAGE:5178265), complete cds.
AY987011 - Homo sapiens calcium/calmodulin-dependent protein kinase II delta mRNA, complete cds, alternatively spliced.
EU176241 - Synthetic construct Homo sapiens clone IMAGE:100006427; FLH182803.01X; RZPDo839H07250D calcium/calmodulin-dependent protein kinase (CaM kinase) II delta (CAMK2D) gene, encodes complete protein.
KJ896536 - Synthetic construct Homo sapiens clone ccsbBroadEn_05930 CAMK2D gene, encodes complete protein.
KJ905159 - Synthetic construct Homo sapiens clone ccsbBroadEn_14565 CAMK2D gene, encodes complete protein.
DQ895255 - Synthetic construct Homo sapiens clone IMAGE:100009715; FLH182796.01L; RZPDo839C05139D calcium/calmodulin-dependent protein kinase (CaM kinase) II delta (CAMK2D) gene, encodes complete protein.
AB384909 - Synthetic construct DNA, clone: pF1KB4158, Homo sapiens CAMK2D gene for calcium/calmodulin-dependent protein kinase type II delta chain, complete cds, without stop codon, in Flexi system.
U50361 - Human calcium, calmodulin-dependent protein kinase II delta mRNA, partial cds.
U73738 - Human calcium/calmodulin-dependent protein kinase II delta E mRNA, partial cds.
EF139846 - Homo sapiens clone 1-4 calcium/calmodulin-dependent protein kinase II splice variant (CAMK2D) mRNA, partial sequence; alternatively spliced.
BC022558 - Homo sapiens calcium/calmodulin-dependent protein kinase II delta, mRNA (cDNA clone IMAGE:4794502), partial cds.
AJ252239 - Homo sapiens partial mRNA for calcium/calmodulin dependent protein kinase II delta (CaMK II delta gene).
BX647363 - Homo sapiens mRNA; cDNA DKFZp686I2288 (from clone DKFZp686I2288).
BX538071 - Homo sapiens mRNA; cDNA DKFZp686G23119 (from clone DKFZp686G23119).
JD261836 - Sequence 242860 from Patent EP1572962.
JD309687 - Sequence 290711 from Patent EP1572962.
JD046806 - Sequence 27830 from Patent EP1572962.
JD243657 - Sequence 224681 from Patent EP1572962.
JD146513 - Sequence 127537 from Patent EP1572962.
JD259764 - Sequence 240788 from Patent EP1572962.
JD095188 - Sequence 76212 from Patent EP1572962.
JD503956 - Sequence 484980 from Patent EP1572962.
JD242528 - Sequence 223552 from Patent EP1572962.
JD567108 - Sequence 548132 from Patent EP1572962.
JD556999 - Sequence 538023 from Patent EP1572962.
JD552015 - Sequence 533039 from Patent EP1572962.
JD162157 - Sequence 143181 from Patent EP1572962.
JD300558 - Sequence 281582 from Patent EP1572962.
JD551019 - Sequence 532043 from Patent EP1572962.
JD295190 - Sequence 276214 from Patent EP1572962.
JD263637 - Sequence 244661 from Patent EP1572962.
JD553078 - Sequence 534102 from Patent EP1572962.
JD302789 - Sequence 283813 from Patent EP1572962.
JD097080 - Sequence 78104 from Patent EP1572962.
JD521530 - Sequence 502554 from Patent EP1572962.
JD556034 - Sequence 537058 from Patent EP1572962.
JD396552 - Sequence 377576 from Patent EP1572962.
JD473842 - Sequence 454866 from Patent EP1572962.
JD412454 - Sequence 393478 from Patent EP1572962.
JD065186 - Sequence 46210 from Patent EP1572962.
JD124637 - Sequence 105661 from Patent EP1572962.
JD075743 - Sequence 56767 from Patent EP1572962.
JD336951 - Sequence 317975 from Patent EP1572962.
JD222570 - Sequence 203594 from Patent EP1572962.
JD174177 - Sequence 155201 from Patent EP1572962.
JD203962 - Sequence 184986 from Patent EP1572962.
JD140763 - Sequence 121787 from Patent EP1572962.
JD142252 - Sequence 123276 from Patent EP1572962.
JD399317 - Sequence 380341 from Patent EP1572962.
JD193180 - Sequence 174204 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CAMK2D , E9PF82, E9PF82_HUMAN, ENST00000511664.1, ENST00000511664.2, ENST00000511664.3, ENST00000511664.4, ENST00000511664.5, NM_001396964, uc323hwz.1, uc323hwz.2
UCSC ID: ENST00000511664.6_12
RefSeq Accession: NM_001321571.2
Protein: E9PF82

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.