Human Gene CAMK2G (ENST00000423381.6_9) from GENCODE V47lift37
  Description: calcium/calmodulin dependent protein kinase II gamma, transcript variant 41 (from RefSeq NM_001367548.1)
Gencode Transcript: ENST00000423381.6_9
Gencode Gene: ENSG00000148660.22_17
Transcript (Including UTRs)
   Position: hg19 chr10:75,572,259-75,634,313 Size: 62,055 Total Exon Count: 23 Strand: -
Coding Region
   Position: hg19 chr10:75,574,773-75,634,219 Size: 59,447 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:75,572,259-75,634,313)mRNA (may differ from genome)Protein (588 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: H0Y6G2_HUMAN
DESCRIPTION: SubName: Full=Calcium/calmodulin-dependent protein kinase type II subunit gamma; Flags: Fragment;
SIMILARITY: Contains 1 protein kinase domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CAMK2G
Diseases sorted by gene-association score: timothy syndrome (10), exudative vitreoretinopathy (5), fibrillary astrocytoma (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 47.41 RPKM in Colon - Sigmoid
Total median expression: 855.91 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -39.1094-0.416 Picture PostScript Text
3' UTR -700.202017-0.347 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020636 - Ca/CaM-dep_Ca-dep_prot_Kinase
IPR013543 - Ca/CaM-dep_prot_kinase-assoc
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase
PF08332 - Calcium/calmodulin dependent protein kinase II association domain
PF13474 - SnoaL-like domain
PF14534 - Domain of unknown function (DUF4440)

SCOP Domains:
56112 - Protein kinase-like (PK-like)
54427 - NTF2-like

ModBase Predicted Comparative 3D Structure on H0Y6G2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004672 protein kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding

Biological Process:
GO:0006468 protein phosphorylation


-  Descriptions from all associated GenBank mRNAs
  AK094774 - Homo sapiens cDNA FLJ37455 fis, clone BRAWH2011079.
BC034044 - Homo sapiens calcium/calmodulin-dependent protein kinase II gamma, mRNA (cDNA clone MGC:26678 IMAGE:4813948), complete cds.
AK291704 - Homo sapiens cDNA FLJ77153 complete cds, highly similar to Homo sapiens calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma (CAMK2G), transcript variant 3, mRNA.
AK225771 - Homo sapiens mRNA for calcium/calmodulin-dependent protein kinase II gamma isoform 3 variant, clone: FCC133B07.
L07044 - Homo sapiens calcium/calmodulin-dependent protein kinase (CAMK) isoform B mRNA sequence.
AK095576 - Homo sapiens cDNA FLJ38257 fis, clone FCBBF3001235, highly similar to Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17).
DQ892365 - Synthetic construct clone IMAGE:100004995; FLH185612.01X; RZPDo839D01148D calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma (CAMK2G) gene, encodes complete protein.
DQ895574 - Synthetic construct Homo sapiens clone IMAGE:100010034; FLH185608.01L; RZPDo839D01147D calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma (CAMK2G) gene, encodes complete protein.
DQ896692 - Synthetic construct Homo sapiens clone IMAGE:100011152; FLH196714.01L; RZPDo839H04155D calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma (CAMK2G) gene, encodes complete protein.
AB590440 - Synthetic construct DNA, clone: pFN21AE0974, Homo sapiens CAMK2G gene for calcium/calmodulin-dependent protein kinase II gamma, without stop codon, in Flexi system.
AK131199 - Homo sapiens cDNA FLJ16043 fis, clone BRCAN2028355, highly similar to Calcium/calmodulin-dependent protein kinasetype II gamma chain (EC 2.7.11.17).
AK301180 - Homo sapiens cDNA FLJ52939 complete cds, moderately similar to Calcium/calmodulin-dependent protein kinasetype II gamma chain (EC 2.7.11.17).
U66064 - Homo sapiens calcium/calmodulin-dependent protein kinase II mRNA, partial cds.
BC037928 - Homo sapiens calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma, mRNA (cDNA clone IMAGE:5284624).
AK026309 - Homo sapiens cDNA: FLJ22656 fis, clone HSI07655.
BC012795 - Homo sapiens calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma, mRNA (cDNA clone IMAGE:4099187), partial cds.
JD479907 - Sequence 460931 from Patent EP1572962.
JD350194 - Sequence 331218 from Patent EP1572962.
JD288317 - Sequence 269341 from Patent EP1572962.
JD157539 - Sequence 138563 from Patent EP1572962.
JD297920 - Sequence 278944 from Patent EP1572962.
JD132028 - Sequence 113052 from Patent EP1572962.
JD107797 - Sequence 88821 from Patent EP1572962.
JD561254 - Sequence 542278 from Patent EP1572962.
JD178915 - Sequence 159939 from Patent EP1572962.
JD519759 - Sequence 500783 from Patent EP1572962.
JD555095 - Sequence 536119 from Patent EP1572962.
JD518381 - Sequence 499405 from Patent EP1572962.
JD511914 - Sequence 492938 from Patent EP1572962.
JD546998 - Sequence 528022 from Patent EP1572962.
JD422631 - Sequence 403655 from Patent EP1572962.
JD075093 - Sequence 56117 from Patent EP1572962.
JD180904 - Sequence 161928 from Patent EP1572962.
JD277478 - Sequence 258502 from Patent EP1572962.
JD155193 - Sequence 136217 from Patent EP1572962.
JD500970 - Sequence 481994 from Patent EP1572962.
JD221148 - Sequence 202172 from Patent EP1572962.
JD342778 - Sequence 323802 from Patent EP1572962.
JD506994 - Sequence 488018 from Patent EP1572962.
JD224885 - Sequence 205909 from Patent EP1572962.
JD268155 - Sequence 249179 from Patent EP1572962.
JD487550 - Sequence 468574 from Patent EP1572962.
JD560386 - Sequence 541410 from Patent EP1572962.
BC021269 - Homo sapiens calcium/calmodulin-dependent protein kinase II gamma, mRNA (cDNA clone IMAGE:4635566), partial cds.
AB209474 - Homo sapiens mRNA for calcium/calmodulin-dependent protein kinase II gamma isoform 6 variant protein.
U66063 - Homo sapiens calcium/calmodulin-dependent protein kinase II mRNA, partial cds.
JD271245 - Sequence 252269 from Patent EP1572962.
JD158523 - Sequence 139547 from Patent EP1572962.
JD520374 - Sequence 501398 from Patent EP1572962.
JD411356 - Sequence 392380 from Patent EP1572962.
JD523236 - Sequence 504260 from Patent EP1572962.
JD146837 - Sequence 127861 from Patent EP1572962.
U50359 - Human calcium, calmodulin-dependent protein kinase II gamma mRNA, partial cds.
U50360 - Human calcium, calmodulin-dependent protein kinase II gamma mRNA, partial cds.
JD161173 - Sequence 142197 from Patent EP1572962.
JD476560 - Sequence 457584 from Patent EP1572962.
JD051272 - Sequence 32296 from Patent EP1572962.
L07043 - Homo sapiens calcium/calmodulin-dependent protein kinase isoform A mRNA, partial cds.
U32472 - Human calmodulin-dependent protein kinase II gamma D isoform mRNA, partial cds.
U32473 - Human calmodulin-dependent protein kinase II gamma E isoform mRNA, partial cds.
U32509 - Human calmodulin-dependent protein kinase II gamma F isoform mRNA, partial cds.
JD405343 - Sequence 386367 from Patent EP1572962.
JD390198 - Sequence 371222 from Patent EP1572962.
JD191364 - Sequence 172388 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CAMK2G , ENST00000423381.1, ENST00000423381.2, ENST00000423381.3, ENST00000423381.4, ENST00000423381.5, H0Y6G2, H0Y6G2_HUMAN, NM_001367548, uc319srk.1, uc319srk.2
UCSC ID: ENST00000423381.6_9
RefSeq Accession: NM_001367534.1
Protein: H0Y6G2

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.