ID:CAND1_HUMAN DESCRIPTION: RecName: Full=Cullin-associated NEDD8-dissociated protein 1; AltName: Full=Cullin-associated and neddylation-dissociated protein 1; AltName: Full=TBP-interacting protein of 120 kDa A; Short=TBP-interacting protein 120A; AltName: Full=p120 CAND1; FUNCTION: Enhances transcription from various types of promoters (By similarity). Regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. Prevents neddylation of CUL1 by physically blocking access to the neddylation site. Disrupts interactions between CUL1 and SKP1 and between CUL1 and F-box proteins. SUBUNIT: Binds TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Binds unneddylated CUL1, but cannot bind CUL1 once it has been neddylated. Binds CUL2, CUL3, CUL4A, CUL4B and CUL5. INTERACTION: Q13616:CUL1; NbExp=18; IntAct=EBI-456077, EBI-359390; Q13617:CUL2; NbExp=3; IntAct=EBI-456077, EBI-456179; Q13618:CUL3; NbExp=2; IntAct=EBI-456077, EBI-456129; Q13619:CUL4A; NbExp=3; IntAct=EBI-456077, EBI-456106; Q13620:CUL4B; NbExp=3; IntAct=EBI-456077, EBI-456067; SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Belongs to the CAND family. SIMILARITY: Contains 27 HEAT repeats. SEQUENCE CAUTION: Sequence=BAA74852.2; Type=Erroneous initiation; Sequence=BAB55090.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86VP6
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
