Human Gene CAP1 (ENST00000372805.8_5) from GENCODE V47lift37
  Description: cyclase associated actin cytoskeleton regulatory protein 1, transcript variant 1 (from RefSeq NM_006367.4)
Gencode Transcript: ENST00000372805.8_5
Gencode Gene: ENSG00000131236.18_16
Transcript (Including UTRs)
   Position: hg19 chr1:40,506,401-40,538,320 Size: 31,920 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr1:40,525,019-40,537,205 Size: 12,187 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:40,506,401-40,538,320)mRNA (may differ from genome)Protein (475 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CAP1_HUMAN
DESCRIPTION: RecName: Full=Adenylyl cyclase-associated protein 1; Short=CAP 1;
FUNCTION: Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
SUBUNIT: Homodimer. Binds actin monomers.
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein (By similarity).
SIMILARITY: Belongs to the CAP family.
SIMILARITY: Contains 1 C-CAP/cofactor C-like domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 237.61 RPKM in Whole Blood
Total median expression: 3249.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.0083-0.349 Picture PostScript Text
3' UTR -314.401115-0.282 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001837 - Adenylate_cyclase-assoc_CAP
IPR013912 - Adenylate_cyclase-assoc_CAP_C
IPR013992 - Adenylate_cyclase-assoc_CAP_N
IPR017901 - C-CAP_CF_C-like
IPR016098 - CAP/MinC_C
IPR018106 - CAP_CS
IPR006599 - CARP_motif

Pfam Domains:
PF01213 - Adenylate cyclase associated (CAP) N terminal
PF08603 - Adenylate cyclase associated (CAP) C terminal

SCOP Domains:
101278 - N-terminal domain of adenylylcyclase associated protein, CAP
101447 - Formin homology 2 domain (FH2 domain)
69340 - C-terminal domain of adenylylcyclase associated protein

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1K8F - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q01518
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGD  WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0008179 adenylate cyclase binding

Biological Process:
GO:0000902 cell morphogenesis
GO:0001667 ameboidal-type cell migration
GO:0006898 receptor-mediated endocytosis
GO:0007010 cytoskeleton organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007165 signal transduction
GO:0007190 activation of adenylate cyclase activity
GO:0008154 actin polymerization or depolymerization
GO:0030036 actin cytoskeleton organization
GO:0043312 neutrophil degranulation

Cellular Component:
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0030864 cortical actin cytoskeleton
GO:0035578 azurophil granule lumen
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC015615 - UNVERIFIED_ASMBLY: Homo sapiens CAP, adenylate cyclase-associated protein 1 (yeast), mRNA (cDNA clone IMAGE:4840674), **** WARNING: chimeric clone ****.
BC006330 - UNVERIFIED_ASMBLY: Homo sapiens mRNA similar to peroxisomal biogenesis factor 6 (cDNA clone IMAGE:4299116).
LF206602 - JP 2014500723-A/14105: Polycomb-Associated Non-Coding RNAs.
HM005631 - Homo sapiens clone HTL-S-218p testis secretory sperm-binding protein Li 218p mRNA, complete cds.
AK315731 - Homo sapiens cDNA, FLJ96836, highly similar to Homo sapiens CAP, adenylate cyclase-associated protein 1 (yeast) (CAP1), mRNA.
AK297829 - Homo sapiens cDNA FLJ53068 complete cds, highly similar to Adenylyl cyclase-associated protein 1.
AK300861 - Homo sapiens cDNA FLJ50235 complete cds, highly similar to Adenylyl cyclase-associated protein 1.
AK096193 - Homo sapiens cDNA FLJ38874 fis, highly similar to ADENYLYL CYCLASE-ASSOCIATED PROTEIN 1.
AK222513 - Homo sapiens mRNA for adenylyl cyclase-associated protein variant, clone: adSE00132.
BC095440 - Homo sapiens CAP, adenylate cyclase-associated protein 1 (yeast), mRNA (cDNA clone MGC:111160 IMAGE:30370256), complete cds.
AK295396 - Homo sapiens cDNA FLJ51857 complete cds, highly similar to Adenylyl cyclase-associated protein 1.
AK298110 - Homo sapiens cDNA FLJ54271 complete cds, highly similar to Adenylyl cyclase-associated protein 1.
M98474 - Human CAP protein (CAP) mRNA, complete cds.
AK298094 - Homo sapiens cDNA FLJ52340 complete cds, highly similar to Adenylyl cyclase-associated protein 1.
BC013963 - Homo sapiens CAP, adenylate cyclase-associated protein 1 (yeast), mRNA (cDNA clone MGC:4492 IMAGE:2963922), complete cds.
L12168 - Homo sapiens adenylyl cyclase-associated protein (CAP) mRNA, complete cds.
BC017196 - Homo sapiens cDNA clone IMAGE:3139224, **** WARNING: chimeric clone ****.
CU680712 - Synthetic construct Homo sapiens gateway clone IMAGE:100019573 5' read CAP1 mRNA.
AB590394 - Synthetic construct DNA, clone: pFN21AE1541, Homo sapiens CAP1 gene for CAP, adenylate cyclase-associated protein 1, without stop codon, in Flexi system.
DQ893840 - Synthetic construct Homo sapiens clone IMAGE:100008300; FLH164863.01L; RZPDo839D01157D CAP, adenylate cyclase-associated protein 1 (yeast) (CAP1) gene, encodes complete protein.
BT007152 - Homo sapiens adenylyl cyclase-associated protein mRNA, complete cds.
DQ890660 - Synthetic construct clone IMAGE:100003290; FLH164867.01X; RZPDo839D01158D CAP, adenylate cyclase-associated protein 1 (yeast) (CAP1) gene, encodes complete protein.
KJ893060 - Synthetic construct Homo sapiens clone ccsbBroadEn_02454 CAP1 gene, encodes complete protein.
CR457409 - Homo sapiens full open reading frame cDNA clone RZPDo834B0814D for gene CAP1, CAP, adenylate cyclase-associated protein 1 (yeast); complete cds, incl. stopcodon.
LF356469 - JP 2014500723-A/163972: Polycomb-Associated Non-Coding RNAs.
LF356468 - JP 2014500723-A/163971: Polycomb-Associated Non-Coding RNAs.
DQ585324 - Homo sapiens piRNA piR-52436, complete sequence.
JD026408 - Sequence 7432 from Patent EP1572962.
LF356464 - JP 2014500723-A/163967: Polycomb-Associated Non-Coding RNAs.
LF356463 - JP 2014500723-A/163966: Polycomb-Associated Non-Coding RNAs.
LF356462 - JP 2014500723-A/163965: Polycomb-Associated Non-Coding RNAs.
BC020367 - Homo sapiens CAP, adenylate cyclase-associated protein 1 (yeast), mRNA (cDNA clone IMAGE:4148660).
LF356461 - JP 2014500723-A/163964: Polycomb-Associated Non-Coding RNAs.
JD537561 - Sequence 518585 from Patent EP1572962.
JD537560 - Sequence 518584 from Patent EP1572962.
LF356460 - JP 2014500723-A/163963: Polycomb-Associated Non-Coding RNAs.
JD073281 - Sequence 54305 from Patent EP1572962.
JD167304 - Sequence 148328 from Patent EP1572962.
JD432295 - Sequence 413319 from Patent EP1572962.
JD268550 - Sequence 249574 from Patent EP1572962.
JD194977 - Sequence 176001 from Patent EP1572962.
JD548543 - Sequence 529567 from Patent EP1572962.
JD494390 - Sequence 475414 from Patent EP1572962.
JD060076 - Sequence 41100 from Patent EP1572962.
JD404148 - Sequence 385172 from Patent EP1572962.
LF356459 - JP 2014500723-A/163962: Polycomb-Associated Non-Coding RNAs.
JD368718 - Sequence 349742 from Patent EP1572962.
JD065529 - Sequence 46553 from Patent EP1572962.
JD339338 - Sequence 320362 from Patent EP1572962.
JD059859 - Sequence 40883 from Patent EP1572962.
DL492151 - Novel nucleic acids.
JD431436 - Sequence 412460 from Patent EP1572962.
BX537801 - Homo sapiens mRNA; cDNA DKFZp686N1682 (from clone DKFZp686N1682).
JD281748 - Sequence 262772 from Patent EP1572962.
MA442179 - JP 2018138019-A/14105: Polycomb-Associated Non-Coding RNAs.
MA592046 - JP 2018138019-A/163972: Polycomb-Associated Non-Coding RNAs.
MA592045 - JP 2018138019-A/163971: Polycomb-Associated Non-Coding RNAs.
MA592041 - JP 2018138019-A/163967: Polycomb-Associated Non-Coding RNAs.
MA592040 - JP 2018138019-A/163966: Polycomb-Associated Non-Coding RNAs.
MA592039 - JP 2018138019-A/163965: Polycomb-Associated Non-Coding RNAs.
MA592038 - JP 2018138019-A/163964: Polycomb-Associated Non-Coding RNAs.
MA592037 - JP 2018138019-A/163963: Polycomb-Associated Non-Coding RNAs.
MA592036 - JP 2018138019-A/163962: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_mPRPathway - How Progesterone Initiates the Oocyte Maturation

Reactome (by CSHL, EBI, and GO)

Protein Q01518 (Reactome details) participates in the following event(s):

R-HSA-482775 Release of (inferred) platelet cytosolic components
R-HSA-6798751 Exocytosis of azurophil granule lumen proteins
R-HSA-428883 Recruitment of CAP to ABL
R-HSA-114608 Platelet degranulation
R-HSA-6798695 Neutrophil degranulation
R-HSA-428890 Role of ABL in ROBO-SLIT signaling
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
R-HSA-168249 Innate Immune System
R-HSA-376176 Signaling by ROBO receptors
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-168256 Immune System
R-HSA-422475 Axon guidance
R-HSA-109582 Hemostasis
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: CAP, CAP1_HUMAN, ENST00000372805.1, ENST00000372805.2, ENST00000372805.3, ENST00000372805.4, ENST00000372805.5, ENST00000372805.6, ENST00000372805.7, NM_006367, Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6, uc318kfn.1, uc318kfn.2
UCSC ID: ENST00000372805.8_5
RefSeq Accession: NM_006367.4
Protein: Q01518 (aka CAP1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.