Human Gene CAP2 (ENST00000229922.7_4) from GENCODE V47lift37
  Description: cyclase associated actin cytoskeleton regulatory protein 2, transcript variant 1 (from RefSeq NM_006366.3)
Gencode Transcript: ENST00000229922.7_4
Gencode Gene: ENSG00000112186.13_8
Transcript (Including UTRs)
   Position: hg19 chr6:17,393,826-17,558,011 Size: 164,186 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr6:17,421,787-17,556,673 Size: 134,887 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:17,393,826-17,558,011)mRNA (may differ from genome)Protein (477 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CAP2_HUMAN
DESCRIPTION: RecName: Full=Adenylyl cyclase-associated protein 2; Short=CAP 2;
FUNCTION: May have a regulatory bifunctional role.
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein (By similarity).
SIMILARITY: Belongs to the CAP family.
SIMILARITY: Contains 1 C-CAP/cofactor C-like domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 125.62 RPKM in Muscle - Skeletal
Total median expression: 683.15 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.10153-0.341 Picture PostScript Text
3' UTR -280.201338-0.209 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001837 - Adenylate_cyclase-assoc_CAP
IPR013912 - Adenylate_cyclase-assoc_CAP_C
IPR013992 - Adenylate_cyclase-assoc_CAP_N
IPR017901 - C-CAP_CF_C-like
IPR016098 - CAP/MinC_C
IPR018106 - CAP_CS
IPR006599 - CARP_motif

Pfam Domains:
PF01213 - Adenylate cyclase associated (CAP) N terminal
PF08603 - Adenylate cyclase associated (CAP) C terminal

SCOP Domains:
101278 - N-terminal domain of adenylylcyclase associated protein, CAP
101447 - Formin homology 2 domain (FH2 domain)
69340 - C-terminal domain of adenylylcyclase associated protein

ModBase Predicted Comparative 3D Structure on P40123
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details   Gene Details
Gene SorterGene Sorter   Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008179 adenylate cyclase binding
GO:0042802 identical protein binding

Biological Process:
GO:0000902 cell morphogenesis
GO:0007010 cytoskeleton organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007165 signal transduction
GO:0007190 activation of adenylate cyclase activity
GO:0008154 actin polymerization or depolymerization

Cellular Component:
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030864 cortical actin cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  AK312362 - Homo sapiens cDNA, FLJ92683, Homo sapiens CAP, adenylate cyclase-associated protein, 2 (yeast)(CAP2), mRNA.
AL832154 - Homo sapiens mRNA; cDNA DKFZp686D0714 (from clone DKFZp686D0714).
AK295600 - Homo sapiens cDNA FLJ50529 complete cds, highly similar to Adenylyl cyclase-associated protein 2.
AK294215 - Homo sapiens cDNA FLJ50475 complete cds, highly similar to Adenylyl cyclase-associated protein 2.
U02390 - Human adenylyl cyclase-associated protein homolog CAP2 (CAP2) mRNA, complete cds.
AK308461 - Homo sapiens cDNA, FLJ98502.
AK293134 - Homo sapiens cDNA FLJ50434 complete cds, highly similar to Adenylyl cyclase-associated protein 2.
AK297538 - Homo sapiens cDNA FLJ59629 complete cds, highly similar to Adenylyl cyclase-associated protein 2.
BC008481 - Homo sapiens CAP, adenylate cyclase-associated protein, 2 (yeast), mRNA (cDNA clone MGC:14779 IMAGE:4295984), complete cds.
CU678975 - Synthetic construct Homo sapiens gateway clone IMAGE:100019586 5' read CAP2 mRNA.
DQ893753 - Synthetic construct Homo sapiens clone IMAGE:100008213; FLH164222.01L; RZPDo839E01161D CAP, adenylate cyclase-associated protein, 2 (yeast) (CAP2) gene, encodes complete protein.
DQ890588 - Synthetic construct clone IMAGE:100003218; FLH164226.01X; RZPDo839E01162D CAP, adenylate cyclase-associated protein, 2 (yeast) (CAP2) gene, encodes complete protein.
KJ898226 - Synthetic construct Homo sapiens clone ccsbBroadEn_07620 CAP2 gene, encodes complete protein.
CR457022 - Homo sapiens full open reading frame cDNA clone RZPDo834A0118D for gene CAP2, CAP, adenylate cyclase-associated protein, 2 (yeast); complete cds, incl. stopcodon.
JD343609 - Sequence 324633 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P40123 (Reactome details) participates in the following event(s):

R-HSA-428883 Recruitment of CAP to ABL
R-HSA-428890 Role of ABL in ROBO-SLIT signaling
R-HSA-376176 Signaling by ROBO receptors
R-HSA-422475 Axon guidance
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: B2R5Y3, B7Z1C4, B7Z214, CAP2_HUMAN, ENST00000229922.1, ENST00000229922.2, ENST00000229922.3, ENST00000229922.4, ENST00000229922.5, ENST00000229922.6, NM_006366, P40123, Q6IAY2, uc317drt.1, uc317drt.2
UCSC ID: ENST00000229922.7_4
RefSeq Accession: NM_006366.3
Protein: P40123 (aka CAP2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.