ID:CAN6_HUMAN DESCRIPTION: RecName: Full=Calpain-6; AltName: Full=Calpain-like protease X-linked; AltName: Full=Calpamodulin; Short=CalpM; FUNCTION: Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity). SUBUNIT: Interacts (via domain III) with microtubules (By similarity). Interacts (via domain II) with ARHGEF2 (via the N- terminal zinc finger) (By similarity). SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, spindle. Note=During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle. TISSUE SPECIFICITY: Expressed only in placenta. SIMILARITY: Belongs to the peptidase C2 family. SIMILARITY: Contains 1 C2 domain. SIMILARITY: Contains 1 calpain catalytic domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/capn6/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6Q1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
