ID:CAPZB_HUMAN DESCRIPTION: RecName: Full=F-actin-capping protein subunit beta; AltName: Full=CapZ beta; FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. SUBUNIT: Heterodimer of an alpha and a beta subunit. Interacts with ARHGAP17 and RCSD1/CAPZIP. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). SIMILARITY: Belongs to the F-actin-capping protein beta subunit family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 90096 - Subunits of heterodimeric actin filament capping protein Capz
ModBase Predicted Comparative 3D Structure on P47756
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK125085 - Homo sapiens cDNA FLJ43095 fis, clone CORDB2000541, highly similar to F-actin capping protein subunit beta. AK301442 - Homo sapiens cDNA FLJ60094 complete cds, highly similar to F-actin capping protein subunit beta. BC107752 - Homo sapiens capping protein (actin filament) muscle Z-line, beta, mRNA (cDNA clone MGC:104401 IMAGE:6715709), complete cds. AK313113 - Homo sapiens cDNA, FLJ93598, highly similar to Homo sapiens capping protein (actin filament) muscle Z-line, beta (CAPZB), mRNA. AK126650 - Homo sapiens cDNA FLJ44693 fis, clone BRACE3014290, weakly similar to Human testicular angiotensin converting enzyme (EC 3.4.15.1). BC008095 - Homo sapiens capping protein (actin filament) muscle Z-line, beta, mRNA (cDNA clone IMAGE:4184742), partial cds. BC012305 - Homo sapiens capping protein (actin filament) muscle Z-line, beta, mRNA (cDNA clone IMAGE:4475822). AK022336 - Homo sapiens cDNA FLJ12274 fis, clone MAMMA1001679. U03271 - Human F-actin capping protein beta subunit mRNA, complete cds. KJ905706 - Synthetic construct Homo sapiens clone ccsbBroadEn_15376 CAPZB gene, encodes complete protein. JD269361 - Sequence 250385 from Patent EP1572962. BC024601 - Homo sapiens capping protein (actin filament) muscle Z-line, beta, mRNA (cDNA clone IMAGE:3864139), partial cds. JD433850 - Sequence 414874 from Patent EP1572962. BC109241 - Homo sapiens capping protein (actin filament) muscle Z-line, beta, mRNA (cDNA clone MGC:129749 IMAGE:40015623), complete cds. BC109242 - Homo sapiens capping protein (actin filament) muscle Z-line, beta, mRNA (cDNA clone MGC:129750 IMAGE:40015624), complete cds. GQ900984 - Homo sapiens clone HEL-T-96 epididymis secretory sperm binding protein mRNA, complete cds. JD354507 - Sequence 335531 from Patent EP1572962. BT019470 - Homo sapiens capping protein (actin filament) muscle Z-line, beta mRNA, complete cds. BT019471 - Homo sapiens capping protein (actin filament) muscle Z-line, beta mRNA, complete cds. KJ890824 - Synthetic construct Homo sapiens clone ccsbBroadEn_00218 CAPZB gene, encodes complete protein. JD025795 - Sequence 6819 from Patent EP1572962. JD034693 - Sequence 15717 from Patent EP1572962. JD026388 - Sequence 7412 from Patent EP1572962. JD028838 - Sequence 9862 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P47756 (Reactome details) participates in the following event(s):
R-HSA-879459 F-actin capping protein is a heterodimer R-HSA-994148 LRRC16A binds F-actin capping protein R-HSA-994169 F-actin capping protein binds to the barbed end of elongating F-actin R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-8849350 RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-109582 Hemostasis R-HSA-2132295 MHC class II antigen presentation R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic R-HSA-1280218 Adaptive Immune System R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-168256 Immune System R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
