Human Gene CARD6 (ENST00000254691.10_10) from GENCODE V47lift37
  Description: caspase recruitment domain family member 6 (from RefSeq NM_032587.4)
Gencode Transcript: ENST00000254691.10_10
Gencode Gene: ENSG00000132357.14_12
Transcript (Including UTRs)
   Position: hg19 chr5:40,841,469-40,855,456 Size: 13,988 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr5:40,841,485-40,854,548 Size: 13,064 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:40,841,469-40,855,456)mRNA (may differ from genome)Protein (1037 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CARD6_HUMAN
DESCRIPTION: RecName: Full=Caspase recruitment domain-containing protein 6;
FUNCTION: May be involved in apoptosis.
SIMILARITY: Contains 1 CARD domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.22 RPKM in Spleen
Total median expression: 136.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR 0.00160.000 Picture PostScript Text
3' UTR -247.70908-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001315 - CARD
IPR011029 - DEATH-like

Pfam Domains:
PF00619 - Caspase recruitment domain

SCOP Domains:
47986 - DEATH domain

ModBase Predicted Comparative 3D Structure on Q9BX69
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006915 apoptotic process
GO:0042981 regulation of apoptotic process


-  Descriptions from all associated GenBank mRNAs
  AF356193 - Homo sapiens caspase recruitment domain protein 6 mRNA, complete cds.
AY196783 - Homo sapiens CINCIN1 (CINCIN1) mRNA, complete cds.
BC093825 - Homo sapiens caspase recruitment domain family, member 6, mRNA (cDNA clone MGC:120860 IMAGE:7939670), complete cds.
AK304349 - Homo sapiens cDNA FLJ56560 complete cds, highly similar to Caspase recruitment domain-containing protein 6.
KJ899821 - Synthetic construct Homo sapiens clone ccsbBroadEn_09215 CARD6 gene, encodes complete protein.
AB209844 - Homo sapiens mRNA for caspase recruitment domain family, member 6 variant protein.
JD084949 - Sequence 65973 from Patent EP1572962.
JD352902 - Sequence 333926 from Patent EP1572962.
JD526229 - Sequence 507253 from Patent EP1572962.
JD407478 - Sequence 388502 from Patent EP1572962.
JD212582 - Sequence 193606 from Patent EP1572962.
JD543938 - Sequence 524962 from Patent EP1572962.
JD514197 - Sequence 495221 from Patent EP1572962.
JD514195 - Sequence 495219 from Patent EP1572962.
JD514196 - Sequence 495220 from Patent EP1572962.
JD070735 - Sequence 51759 from Patent EP1572962.
JD070733 - Sequence 51757 from Patent EP1572962.
JD070734 - Sequence 51758 from Patent EP1572962.
JD359693 - Sequence 340717 from Patent EP1572962.
JD242944 - Sequence 223968 from Patent EP1572962.
JD418101 - Sequence 399125 from Patent EP1572962.
JD347750 - Sequence 328774 from Patent EP1572962.
JD233689 - Sequence 214713 from Patent EP1572962.
JD240491 - Sequence 221515 from Patent EP1572962.
JD491025 - Sequence 472049 from Patent EP1572962.
JD241542 - Sequence 222566 from Patent EP1572962.
JD404339 - Sequence 385363 from Patent EP1572962.
JD066232 - Sequence 47256 from Patent EP1572962.
JD315656 - Sequence 296680 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CARD6_HUMAN, ENST00000254691.1, ENST00000254691.2, ENST00000254691.3, ENST00000254691.4, ENST00000254691.5, ENST00000254691.6, ENST00000254691.7, ENST00000254691.8, ENST00000254691.9, NM_032587, Q52LR2, Q9BX69, uc317fpc.1, uc317fpc.2
UCSC ID: ENST00000254691.10_10
RefSeq Accession: NM_032587.4
Protein: Q9BX69 (aka CARD6_HUMAN or CAR6_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.