Human Gene CASP3 (ENST00000308394.9_7) from GENCODE V47lift37
  Description: caspase 3, transcript variant 1 (from RefSeq NM_004346.4)
Gencode Transcript: ENST00000308394.9_7
Gencode Gene: ENSG00000164305.20_13
Transcript (Including UTRs)
   Position: hg19 chr4:185,548,850-185,570,601 Size: 21,752 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr4:185,550,426-185,559,607 Size: 9,182 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:185,548,850-185,570,601)mRNA (may differ from genome)Protein (277 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
Human Cortex Gene ExpressionMalacardsMGIOMIMPubMedReactome
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CASP3_HUMAN
DESCRIPTION: RecName: Full=Caspase-3; Short=CASP-3; EC=3.4.22.56; AltName: Full=Apopain; AltName: Full=Cysteine protease CPP32; Short=CPP-32; AltName: Full=Protein Yama; AltName: Full=SREBP cleavage activity 1; Short=SCA-1; Contains: RecName: Full=Caspase-3 subunit p17; Contains: RecName: Full=Caspase-3 subunit p12; Flags: Precursor;
FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
CATALYTIC ACTIVITY: Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp- Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position.
ENZYME REGULATION: Inhibited by isatin sulfonamides.
SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce.
INTERACTION: Q9BYP7:WNK3; NbExp=2; IntAct=EBI-524064, EBI-1182602;
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
PTM: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
PTM: S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.
SIMILARITY: Belongs to the peptidase C14A family.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/casp3/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CASP3
Diseases sorted by gene-association score: lung cancer (15), nervous system cancer (14), chronic myelocytic leukemia (13), huntington disease (11), retinal ischemia (11), colon adenocarcinoma (11), bladder urothelial carcinoma (11), hepatocellular carcinoma (11), ischemia (11), spinal cord injury (10), oral lichen planus (10), short-rib thoracic dysplasia 4 with or without polydactyly (10), charcot-marie-tooth disease, axonal, type 2cc (10), nutmeg liver (10), monocytic leukemia (9), cervical cancer, somatic (9), hepatoblastoma (9), transient cerebral ischemia (9), malignant glioma (9), colorectal cancer (9), cowpox (9), tongue squamous cell carcinoma (8), krabbe disease (8), alzheimer disease (8), heterophyiasis (8), deafness, autosomal recessive 74 (8), nasopharyngeal carcinoma (7), primary effusion lymphoma (7), varicocele (7), fatty liver disease (7), colon adenoma (7), breast cancer (7), traumatic brain injury (7), deafness, autosomal dominant 24 (7), spermatic cord torsion (7), lung cancer susceptibility 3 (7), prostate calculus (7), oral squamous cell carcinoma (7), ehrlichiosis (7), toxic encephalopathy (6), reticulosarcoma (6), alzheimer disease mitochondrial (6), crimean-congo hemorrhagic fever (6), osteosarcoma, somatic (6), status epilepticus (6), lower lip cancer (6), salivary gland cancer (6), lymphadenitis (6), newcastle disease (6), oral cancer (6), pancreatic cancer (6), skin melanoma (6), myasthenic syndrome, congenital, 13, with tubular aggregates (5), autonomic nervous system neoplasm (5), spotted fever (5), panniculitis (5), brain injury (5), occlusion precerebral artery (5), leukemia, acute promyelocytic, somatic (5), peripheral nervous system neoplasm (5), internal hemorrhoid (5), spinocerebellar ataxia 14 (5), cerebral hypoxia (5), testicular disease (5), ovarian cancer, somatic (4), prostate cancer (4), stomach cancer (4), idiopathic neutropenia (4), gastric adenocarcinoma (4), chronic lymphocytic leukemia (4), b-cell lymphomas (4), sudden infant death syndrome (3), endometrial cancer (3), lateral sclerosis (3), esophageal cancer (3), medulloblastoma (2), urinary bladder cancer (2), leukemia, chronic myeloid, somatic (2), mantle cell lymphoma (2), parkinson disease, late-onset (2), multiple myeloma (2), fanconi anemia, complementation group a (2), gastrointestinal system cancer (2), reproductive organ cancer (2), pheochromocytoma (2), neuroblastoma (2), adamantinoma of long bones (2), malaria (1), cardiomyopathy, familial hypertrophic (1), amyotrophic lateral sclerosis 1 (1), nervous system disease (1), male reproductive organ cancer (1), female reproductive organ cancer (1), myocardial infarction (1), macular degeneration, age-related, 1 (1), pharynx cancer (1), cell type cancer (1), gastric cancer, somatic (1), leukemia, acute myeloid (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 30.05 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 405.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -83.80235-0.357 Picture PostScript Text
3' UTR -387.101576-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015470 - Caspase_3
IPR011600 - Pept_C14_cat
IPR001309 - Pept_C14_ICE_p20
IPR016129 - Pept_C14_ICE_p20_AS
IPR002138 - Pept_C14_p10
IPR002398 - Pept_C14_p45
IPR015917 - Pept_C14_p45_core

Pfam Domains:
PF00656 - Caspase domain

SCOP Domains:
52129 - Caspase-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1CP3 - X-ray MuPIT 1GFW - X-ray MuPIT 1I3O - X-ray MuPIT 1NME - X-ray MuPIT 1NMQ - X-ray MuPIT 1NMS - X-ray MuPIT 1PAU - X-ray MuPIT 1QX3 - X-ray MuPIT 1RE1 - X-ray MuPIT 1RHJ - X-ray MuPIT 1RHK - X-ray MuPIT 1RHM - X-ray MuPIT 1RHQ - X-ray MuPIT 1RHR - X-ray MuPIT 1RHU - X-ray MuPIT 2C1E - X-ray MuPIT 2C2K - X-ray MuPIT 2C2M - X-ray MuPIT 2C2O - X-ray 2CDR - X-ray MuPIT 2CJX - X-ray MuPIT 2CJY - X-ray MuPIT 2CNK - X-ray 2CNL - X-ray 2CNN - X-ray 2CNO - X-ray MuPIT 2DKO - X-ray MuPIT 2H5I - X-ray MuPIT 2H5J - X-ray MuPIT 2H65 - X-ray MuPIT 2J30 - X-ray MuPIT 2J31 - X-ray MuPIT 2J32 - X-ray MuPIT 2J33 - X-ray MuPIT 2XYG - X-ray 2XYH - X-ray 2XYP - X-ray 2XZD - X-ray MuPIT 2XZT - X-ray MuPIT 2Y0B - X-ray MuPIT 3DEH - X-ray MuPIT 3DEI - X-ray MuPIT 3DEJ - X-ray MuPIT 3DEK - X-ray MuPIT 3EDQ - X-ray MuPIT 3GJQ - X-ray MuPIT 3GJR - X-ray MuPIT 3GJS - X-ray MuPIT 3GJT - X-ray MuPIT 3H0E - X-ray MuPIT 3ITN - X-ray MuPIT 3KJF - X-ray MuPIT 3PCX - X-ray MuPIT 3PD0 - X-ray MuPIT 3PD1 - X-ray MuPIT 4EHA - X-ray MuPIT 4EHD - X-ray MuPIT 4EHF - X-ray MuPIT 4EHH - X-ray MuPIT 4EHK - X-ray MuPIT 4EHL - X-ray MuPIT 4EHN - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P42574
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0002020 protease binding
GO:0004190 aspartic-type endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005123 death receptor binding
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0016005 phospholipase A2 activator activity
GO:0016787 hydrolase activity
GO:0044877 macromolecular complex binding
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis

Biological Process:
GO:0001666 response to hypoxia
GO:0001782 B cell homeostasis
GO:0006309 apoptotic DNA fragmentation
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007507 heart development
GO:0007605 sensory perception of sound
GO:0007611 learning or memory
GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress
GO:0009411 response to UV
GO:0009611 response to wounding
GO:0009749 response to glucose
GO:0010033 response to organic substance
GO:0010038 response to metal ion
GO:0010165 response to X-ray
GO:0014070 response to organic cyclic compound
GO:0016241 regulation of macroautophagy
GO:0016485 protein processing
GO:0019221 cytokine-mediated signaling pathway
GO:0021766 hippocampus development
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030218 erythrocyte differentiation
GO:0030220 platelet formation
GO:0030889 negative regulation of B cell proliferation
GO:0032025 response to cobalt ion
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0034349 glial cell apoptotic process
GO:0034612 response to tumor necrosis factor
GO:0035094 response to nicotine
GO:0035329 hippo signaling
GO:0035556 intracellular signal transduction
GO:0042060 wound healing
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043029 T cell homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043200 response to amino acid
GO:0043525 positive regulation of neuron apoptotic process
GO:0045165 cell fate commitment
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786 negative regulation of cell cycle
GO:0046007 negative regulation of activated T cell proliferation
GO:0046677 response to antibiotic
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051384 response to glucocorticoid
GO:0051402 neuron apoptotic process
GO:0071310 cellular response to organic substance
GO:0071407 cellular response to organic cyclic compound
GO:0072734 cellular response to staurosporine
GO:0097190 apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097194 execution phase of apoptosis

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031264 death-inducing signaling complex
GO:0045121 membrane raft


-  Descriptions from all associated GenBank mRNAs
  BX647609 - Homo sapiens mRNA; cDNA DKFZp686N1815 (from clone DKFZp686N1815).
BC016926 - Homo sapiens caspase 3, apoptosis-related cysteine peptidase, mRNA (cDNA clone MGC:21241 IMAGE:4419175), complete cds.
HV708958 - JP 2012506450-A/56: Methods for treating eye disorders.
HV708959 - JP 2012506450-A/57: Methods for treating eye disorders.
JA482041 - Sequence 24 from Patent WO2011072091.
JA482042 - Sequence 25 from Patent WO2011072091.
JE980333 - Sequence 24 from Patent EP2862929.
JE980334 - Sequence 25 from Patent EP2862929.
U13737 - Human cysteine protease CPP32 isoform alpha mRNA, complete cds.
JD107257 - Sequence 88281 from Patent EP1572962.
JD104657 - Sequence 85681 from Patent EP1572962.
JD324366 - Sequence 305390 from Patent EP1572962.
JD045505 - Sequence 26529 from Patent EP1572962.
JD404716 - Sequence 385740 from Patent EP1572962.
JD087637 - Sequence 68661 from Patent EP1572962.
JD377438 - Sequence 358462 from Patent EP1572962.
JD041503 - Sequence 22527 from Patent EP1572962.
JD391009 - Sequence 372033 from Patent EP1572962.
JD181645 - Sequence 162669 from Patent EP1572962.
AK291337 - Homo sapiens cDNA FLJ75691 complete cds, highly similar to Homo sapiens caspase 3, apoptosis-related cysteine protease(CASP3), transcript variant alpha, mRNA.
JD427514 - Sequence 408538 from Patent EP1572962.
JD090498 - Sequence 71522 from Patent EP1572962.
JD284583 - Sequence 265607 from Patent EP1572962.
JD337172 - Sequence 318196 from Patent EP1572962.
JD510770 - Sequence 491794 from Patent EP1572962.
JD506655 - Sequence 487679 from Patent EP1572962.
U13738 - Human cysteine protease CPP32 isoform beta mRNA, complete cds.
JD555029 - Sequence 536053 from Patent EP1572962.
AJ413269 - Homo sapiens mRNA for caspase-3 (CASP3 gene), N-terminal mutant form.
U26943 - Human cysteine protease Yama mRNA, complete cds.
KJ890827 - Synthetic construct Homo sapiens clone ccsbBroadEn_00221 CASP3 gene, encodes complete protein.
DQ891543 - Synthetic construct clone IMAGE:100004173; FLH177878.01X; RZPDo839E12126D caspase 3, apoptosis-related cysteine peptidase (CASP3) gene, encodes complete protein.
DQ894731 - Synthetic construct Homo sapiens clone IMAGE:100009191; FLH177874.01L; RZPDo839E12125D caspase 3, apoptosis-related cysteine peptidase (CASP3) gene, encodes complete protein.
AB590261 - Synthetic construct DNA, clone: pFN21AE1435, Homo sapiens CASP3 gene for caspase 3, apoptosis-related cysteine peptidase, without stop codon, in Flexi system.
JD220744 - Sequence 201768 from Patent EP1572962.
JD489941 - Sequence 470965 from Patent EP1572962.
JD427400 - Sequence 408424 from Patent EP1572962.
JD266867 - Sequence 247891 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_DNAfragmentPathway - Apoptotic DNA fragmentation and tissue homeostasis
h_fasPathway - FAS signaling pathway ( CD95 )
h_tnfr1Pathway - TNFR1 Signaling Pathway
h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF
h_d4gdiPathway - D4-GDI Signaling Pathway
h_tsp1Pathway - TSP-1 Induced Apoptosis in Microvascular Endothelial Cell
h_bcellsurvivalPathway - B Cell Survival Pathway
h_chemicalPathway - Apoptotic Signaling in Response to DNA Damage
h_hsp27Pathway - Stress Induction of HSP Regulation
h_caspasePathway - Caspase Cascade in Apoptosis
h_deathPathway - Induction of apoptosis through DR3 and DR4/5 Death Receptors
h_mitochondriaPathway - Role of Mitochondria in Apoptotic Signaling

Reactome (by CSHL, EBI, and GO)

Protein P42574 (Reactome details) participates in the following event(s):

R-HSA-114252 Cleavage of Procaspase-3 by the apoptosome
R-HSA-418845 Activation of caspase-3
R-HSA-205117 p75NTR:NADE promotes caspase2/3 activation
R-HSA-211219 Translocation of caspase-3 to the nucleus
R-HSA-114419 Dissociation of Caspase-3 from SMAC:XIAP:Caspase-3
R-HSA-114306 SMAC binds XIAP:Caspase-3
R-HSA-201595 Caspase-mediated cleavage of plakophilin-1
R-HSA-201603 Caspase-mediated cleavage of PKC theta
R-HSA-201608 Caspase-mediated cleavage of alpha adducin
R-HSA-201611 Caspase-mediated cleavage of Rock-1
R-HSA-201622 Caspase-mediated cleavage of gelsolin
R-HSA-201629 Caspase-mediated cleavage of Tau
R-HSA-201630 Caspase-mediated cleavage of Acinus
R-HSA-201631 Caspase-mediated cleavage of Desmoglein 3
R-HSA-201636 Caspase-mediated cleavage of Desmoplakin
R-HSA-201640 Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha
R-HSA-202917 Caspase-mediated cleavage of Desmoglein 1
R-HSA-202939 Caspase-mediated cleavage of E-Cadherin
R-HSA-202947 Caspase mediated cleavage of APC
R-HSA-202960 Caspase mediated cleavage of C-IAP1
R-HSA-202966 Caspase mediated cleavage of HIP-55
R-HSA-202967 Caspase mediated cleavage of alpha-II-Fodrin
R-HSA-202969 Caspase mediated cleavage of beta-catenin
R-NUL-211643 Cleavage of PAK-2 at 212
R-HSA-211651 Cleavage of PAK-2 at 212
R-HSA-212552 Caspase 3-mediated cleavage of PKC delta
R-HSA-350651 Caspase-mediated cleavage of MASK
R-HSA-351849 Caspase-mediated cleavage of Etk
R-HSA-351871 Caspase-mediated cleavage of Z0-2
R-HSA-351876 Caspase-mediated cleavage of occludin
R-HSA-351877 Caspase-mediated cleavage of Desmoglein 2
R-HSA-351913 Caspase-mediated cleavage of TJP1
R-HSA-418846 Caspase cleavage of UNC5A
R-HSA-418852 Caspase cleavage of UNC5B
R-HSA-2028692 Cleavage of p-STK4 (p-MST1) by caspase 3
R-HSA-2028697 Cleavage of p-STK3 (p-MST2) by caspase 3
R-HSA-449073 Caspase-3 cleaves pro-interleukin-16
R-HSA-373705 Caspase cleavage of DCC
R-HSA-211186 Cleavage of DFF45 (224) by caspase-3
R-HSA-211190 Caspase 3-mediated cleavage of DFF45 (117)
R-HSA-201628 Caspase-mediated cleavage of vimentin at DSVD (85)
R-HSA-201639 Caspase-mediated cleavage of GAS2
R-HSA-351901 Caspase-mediated cleavage of MST3
R-HSA-2534260 E-cadherin degradation by caspase-3 and calpain-1
R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage
R-HSA-418889 Ligand-independent caspase activation via DCC
R-HSA-205025 NADE modulates death signalling
R-HSA-111461 Cytochrome c-mediated apoptotic response
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE
R-HSA-211227 Activation of DNA fragmentation factor
R-HSA-111464 SMAC-mediated dissociation of IAP:caspase complexes
R-HSA-111471 Apoptotic factor-mediated response
R-HSA-109581 Apoptosis
R-HSA-193704 p75 NTR receptor-mediated signalling
R-HSA-111463 SMAC binds to IAPs
R-HSA-140342 Apoptosis induced DNA fragmentation
R-HSA-111469 SMAC-mediated apoptotic response
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins
R-HSA-111465 Apoptotic cleavage of cellular proteins
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-211736 Stimulation of the cell death response by PAK-2p34
R-HSA-2028269 Signaling by Hippo
R-HSA-449836 Other interleukin signaling
R-HSA-109606 Intrinsic Pathway for Apoptosis
R-HSA-5357801 Programmed Cell Death
R-HSA-73887 Death Receptor Signalling
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-75153 Apoptotic execution phase
R-HSA-162582 Signal Transduction
R-HSA-449147 Signaling by Interleukins
R-HSA-1474244 Extracellular matrix organization
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: A8K5M2, CASP3_HUMAN, CPP32 , D3DP53, ENST00000308394.1, ENST00000308394.2, ENST00000308394.3, ENST00000308394.4, ENST00000308394.5, ENST00000308394.6, ENST00000308394.7, ENST00000308394.8, NM_004346, P42574, Q96AN1, Q96KP2, uc317oho.1, uc317oho.2
UCSC ID: ENST00000308394.9_7
RefSeq Accession: NM_004346.4
Protein: P42574 (aka CASP3_HUMAN or ICE3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.