Human Gene CASP8 (ENST00000673742.1_7) from GENCODE V47lift37
  Description: caspase 8, transcript variant 67 (from RefSeq NR_174602.1)
Gencode Transcript: ENST00000673742.1_7
Gencode Gene: ENSG00000064012.24_21
Transcript (Including UTRs)
   Position: hg19 chr2:202,125,259-202,152,432 Size: 27,174 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr2:202,131,210-202,151,317 Size: 20,108 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:202,125,259-202,152,432)mRNA (may differ from genome)Protein (479 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
Human Cortex Gene ExpressionMalacardsMGIPubMedReactomeUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: CASP8_HUMAN
DESCRIPTION: RecName: Full=Caspase-8; Short=CASP-8; EC=3.4.22.61; AltName: Full=Apoptotic cysteine protease; AltName: Full=Apoptotic protease Mch-5; AltName: Full=CAP4; AltName: Full=FADD-homologous ICE/ced-3-like protease; AltName: Full=FADD-like ICE; Short=FLICE; AltName: Full=ICE-like apoptotic protease 5; AltName: Full=MORT1-associated ced-3 homolog; Short=MACH; Contains: RecName: Full=Caspase-8 subunit p18; Contains: RecName: Full=Caspase-8 subunit p10; Flags: Precursor;
FUNCTION: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
CATALYTIC ACTIVITY: Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|- (Gly/Ser/Ala).
SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 10 kDa (p10) subunit. Interacts with FADD, CFLAR and PEA15. Isoform 9 interacts at the endoplasmic reticulum with a complex containing BCAP31, BAP29, BCL2 and/or BCL2L1. Interacts with TNFAIP8L2 (By similarity). Interacts with human cytomegalovirus/HHV-5 protein vICA/UL36; this interaction inhibits CASP8 activation.
INTERACTION: Self; NbExp=3; IntAct=EBI-78060, EBI-78060; P51572:BCAP31; NbExp=3; IntAct=EBI-78060, EBI-77683; Q92851:CASP10; NbExp=5; IntAct=EBI-78060, EBI-495095; Q13618:CUL3; NbExp=6; IntAct=EBI-78060, EBI-456129; Q13158:FADD; NbExp=4; IntAct=EBI-288326, EBI-494804; P25445:FAS; NbExp=12; IntAct=EBI-78060, EBI-494743; Q13418:ILK; NbExp=2; IntAct=EBI-78060, EBI-747644; Q9UDY8:MALT1; NbExp=8; IntAct=EBI-78060, EBI-1047372; O60936:NOL3; NbExp=3; IntAct=EBI-78060, EBI-740992; Q13546:RIPK1; NbExp=23; IntAct=EBI-78060, EBI-358507; O00220:TNFRSF10A; NbExp=9; IntAct=EBI-78060, EBI-518861;
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle.
DOMAIN: Isoform 9 contains a N-terminal extension that is required for interaction with the BCAP31 complex.
PTM: Generation of the subunits requires association with the death-inducing signaling complex (DISC), whereas additional processing is likely due to the autocatalytic activity of the activated protease. GZMB and CASP10 can be involved in these processing events.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation on Ser-387 during mitosis by CDK1 inhibits activation by proteolysis and prevents apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes.
POLYMORPHISM: Genetic variations in CASP8 are associated with reduced risk of lung cancer [MIM:211980] in a population of Han Chinese subjects. Genetic variations are also associated with decreased risk of cancer of various other forms including esophageal, gastric, colorectal, cervical, and breast, acting in an allele dose-dependent manner.
DISEASE: Defects in CASP8 are the cause of caspase-8 deficiency (CASP8D) [MIM:607271]. CASP8D is a disorder resembling autoimmune lymphoproliferative syndrome (ALPS). It is characterized by lymphadenopathy, splenomegaly, and defective CD95-induced apoptosis of peripheral blood lymphocytes (PBLs). It leads to defects in activation of T-lymphocytes, B-lymphocytes, and natural killer cells leading to immunodeficiency characterized by recurrent sinopulmonary and herpes simplex virus infections and poor responses to immunization.
SIMILARITY: Belongs to the peptidase C14A family.
SIMILARITY: Contains 2 DED (death effector) domains.
SEQUENCE CAUTION: Sequence=CAA66858.1; Type=Miscellaneous discrepancy; Sequence=CAA66859.1; Type=Miscellaneous discrepancy;
WEB RESOURCE: Name=CASP8base; Note=CASP8 mutation db; URL="http://bioinf.uta.fi/CASP8base/";
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CASP8";
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/casp8/";

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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-  MalaCards Disease Associations
  MalaCards Gene Search: CASP8
Diseases sorted by gene-association score: autoimmune lymphoproliferative syndrome, type iib* (1742), hepatocellular carcinoma* (378), adult hepatocellular carcinoma* (202), lung cancer* (192), breast cancer* (125), cowpox (20), autoimmune lymphoproliferative syndrome (19), huntington disease (17), molluscum contagiosum (14), acute t cell leukemia (10), alzheimer disease mitochondrial (10), kaposi sarcoma (10), lymphoproliferative syndrome (9), oral cavity cancer (9), malignant glioma (9), cervical cancer, somatic (8), chronic mountain sickness (7), dystrophinopathies (6), breast adenocarcinoma (5), juvenile amyotrophic lateral sclerosis (5), herpes simplex (5), saethre-chotzen syndrome (5), pneumoconiosis (5), colorectal cancer (5), post-transplant lymphoproliferative disease (5), salivary gland cancer (5), colon adenocarcinoma (4), perry syndrome (3), medulloblastoma (3), prostate cancer (3), chronic lymphocytic leukemia (2), stomach cancer (2), ovarian cancer, somatic (2), pancreatic cancer (2), asthma (2), multiple myeloma (2), leukemia, acute promyelocytic, somatic (2), lung cancer susceptibility 3 (2), osteosarcoma, somatic (1), neuroblastoma (1), autonomic nervous system neoplasm (1), peripheral nervous system neoplasm (1), lymphoma, non-hodgkin (1), leukemia, acute myeloid (0)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.90104-0.249 Picture PostScript Text
3' UTR -388.001115-0.348 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011029 - DEATH-like
IPR001875 - DED
IPR011600 - Pept_C14_cat
IPR001309 - Pept_C14_ICE_p20
IPR016129 - Pept_C14_ICE_p20_AS
IPR002138 - Pept_C14_p10
IPR002398 - Pept_C14_p45
IPR015917 - Pept_C14_p45_core

Pfam Domains:
PF00656 - Caspase domain
PF01335 - Death effector domain

SCOP Domains:
47986 - DEATH domain
52129 - Caspase-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1F9E - X-ray MuPIT 1I4E - X-ray MuPIT 1QDU - X-ray MuPIT 1QTN - X-ray MuPIT 2C2Z - X-ray MuPIT 2FUN - X-ray MuPIT 2K7Z - NMR MuPIT 2Y1L - X-ray MuPIT 3H11 - X-ray MuPIT 3KJN - X-ray MuPIT 3KJQ - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q14790
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004197 cysteine-type endopeptidase activity
GO:0005123 death receptor binding
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0031625 ubiquitin protein ligase binding
GO:0035877 death effector domain binding
GO:0042802 identical protein binding
GO:0044877 macromolecular complex binding
GO:0097110 scaffold protein binding
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis

Biological Process:
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166 cell surface receptor signaling pathway
GO:0009409 response to cold
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016032 viral process
GO:0030101 natural killer cell activation
GO:0030225 macrophage differentiation
GO:0032025 response to cobalt ion
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034612 response to tumor necrosis factor
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0036462 TRAIL-activated apoptotic signaling pathway
GO:0039650 suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045471 response to ethanol
GO:0045651 positive regulation of macrophage differentiation
GO:0045862 positive regulation of proteolysis
GO:0046677 response to antibiotic
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0060544 regulation of necroptotic process
GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0071260 cellular response to mechanical stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071550 death-inducing signaling complex assembly
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:0097202 activation of cysteine-type endopeptidase activity
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901216 positive regulation of neuron death
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0031264 death-inducing signaling complex
GO:0031265 CD95 death-inducing signaling complex
GO:0032991 macromolecular complex
GO:0043005 neuron projection
GO:0044297 cell body
GO:0045121 membrane raft
GO:0097342 ripoptosome


-  Descriptions from all associated GenBank mRNAs
  AF422925 - Homo sapiens procaspase-8L (CASP8) mRNA, complete cds; alternatively spliced.
AF422928 - Homo sapiens clone 3 procaspase-8 (CASP8) mRNA, partial cds; alternatively spliced.
AF422927 - Homo sapiens clone 2 procaspase-8 (CASP8) mRNA, partial cds; alternatively spliced.
AK310630 - Homo sapiens cDNA, FLJ17672.
U60520 - Human apoptotic cysteine protease Mch5 isoform alpha (Mch5) mRNA, complete cds.
X98176 - H.sapiens mRNA for MACH-beta-1 protein.
AF422926 - Homo sapiens clone 1 procaspase-8 (CASP8) mRNA, partial cds; alternatively spliced.
BC068050 - Homo sapiens caspase 8, apoptosis-related cysteine peptidase, mRNA (cDNA clone MGC:78473 IMAGE:6421760), complete cds.
AF422929 - Homo sapiens clone 4 procaspase-8 (CASP8) mRNA, partial cds; alternatively spliced.
X98172 - H.sapiens mRNA for MACH-alpha-1 protein.
AY429525 - Homo sapiens CASP8v_1 mRNA sequence; alternatively spliced.
AF380342 - Homo sapiens caspase-8L mRNA, complete cds.
X98173 - H.sapiens mRNA for MACH-alpha-2 protein.
BC028223 - Homo sapiens caspase 8, apoptosis-related cysteine peptidase, mRNA (cDNA clone IMAGE:5217189).
EU670044 - Homo sapiens caspase 8 short isoform mRNA, complete cds.
KJ901316 - Synthetic construct Homo sapiens clone ccsbBroadEn_10710 CASP8 gene, encodes complete protein.
X98177 - H.sapiens mRNA for MACH-beta-3 protein.
X98178 - H.sapiens mRNA for MACH-beta-4 protein.
AB451414 - Homo sapiens CASP8 mRNA for caspase 8 isoform C precursor, partial cds, clone: FLJ08119AAAF.
AB451282 - Homo sapiens CASP8 mRNA for caspase 8 isoform C precursor, complete cds, clone: FLJ08119AAAN.
AF009620 - Homo sapiens apoptotic caspase Mch5-beta mRNA, alternatively spliced, complete cds.
EU168332 - Homo sapiens caspase 8 splice variant (CASP8) mRNA, complete cds, alternatively spliced.
U58143 - Human FADD-homologous ICE/CED-3-like protease mRNA, complete cds.
JN657192 - Homo sapiens caspase-8 isoform 6 (Casp8) mRNA, partial cds, alternatively spliced.
X98175 - H.sapiens mRNA for MACH-beta-2 protein.
X98174 - H.sapiens mRNA for MACH-alpha-3 protein.
JD378524 - Sequence 359548 from Patent EP1572962.
JD503503 - Sequence 484527 from Patent EP1572962.
JD288405 - Sequence 269429 from Patent EP1572962.
JD376989 - Sequence 358013 from Patent EP1572962.
JD167124 - Sequence 148148 from Patent EP1572962.
JD307827 - Sequence 288851 from Patent EP1572962.
JD044593 - Sequence 25617 from Patent EP1572962.
JD036495 - Sequence 17519 from Patent EP1572962.
JD265835 - Sequence 246859 from Patent EP1572962.
JD352903 - Sequence 333927 from Patent EP1572962.
JD519139 - Sequence 500163 from Patent EP1572962.
JD409323 - Sequence 390347 from Patent EP1572962.
JD215308 - Sequence 196332 from Patent EP1572962.
JD107564 - Sequence 88588 from Patent EP1572962.
JD334416 - Sequence 315440 from Patent EP1572962.
JD508811 - Sequence 489835 from Patent EP1572962.
JD116657 - Sequence 97681 from Patent EP1572962.
JD226344 - Sequence 207368 from Patent EP1572962.
JD243945 - Sequence 224969 from Patent EP1572962.
JD279104 - Sequence 260128 from Patent EP1572962.
JD497851 - Sequence 478875 from Patent EP1572962.
JD543396 - Sequence 524420 from Patent EP1572962.
JD543397 - Sequence 524421 from Patent EP1572962.
JD543398 - Sequence 524422 from Patent EP1572962.
JD478671 - Sequence 459695 from Patent EP1572962.
JD565311 - Sequence 546335 from Patent EP1572962.
JD045154 - Sequence 26178 from Patent EP1572962.
JD080899 - Sequence 61923 from Patent EP1572962.
JD442766 - Sequence 423790 from Patent EP1572962.
JD090814 - Sequence 71838 from Patent EP1572962.
JD549634 - Sequence 530658 from Patent EP1572962.
JD499782 - Sequence 480806 from Patent EP1572962.
JD287155 - Sequence 268179 from Patent EP1572962.
JD512592 - Sequence 493616 from Patent EP1572962.
JD097608 - Sequence 78632 from Patent EP1572962.
JD051112 - Sequence 32136 from Patent EP1572962.
JD099184 - Sequence 80208 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_ceramidePathway - Ceramide Signaling Pathway
h_mitochondriaPathway - Role of Mitochondria in Apoptotic Signaling
h_deathPathway - Induction of apoptosis through DR3 and DR4/5 Death Receptors
h_d4gdiPathway - D4-GDI Signaling Pathway
h_fasPathway - FAS signaling pathway ( CD95 )
h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF
h_soddPathway - SODD/TNFR1 Signaling Pathway
h_caspasePathway - Caspase Cascade in Apoptosis
h_tnfr1Pathway - TNFR1 Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein Q14790 (Reactome details) participates in the following event(s):

R-HSA-73945 FAS-mediated dimerization of procaspase-8
R-HSA-75146 TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8
R-HSA-75240 TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
R-HSA-83586 FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
R-HSA-141156 TRAIL-mediated dimerization of procaspase-8
R-HSA-141159 TNF-mediated dimerization of procaspase-8
R-HSA-2562541 TLR4-induced ripoptosome assembly
R-HSA-5692550 Viral inhibitor of caspase-8 activation (UL36) binds caspase-8
R-HSA-9013889 TLR3-induced ripoptosome assembly
R-HSA-933532 Processing of caspases
R-HSA-3465459 FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling
R-HSA-3371360 FLIP(L) and procaspase-8 form heterodimer in TNF signaling
R-HSA-2562564 Caspase-8 processing within TLR4 complex
R-HSA-3371359 FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling
R-HSA-3465429 FLIP(S) and procaspase-8 form heterodimer
R-HSA-5675456 FLIP(L) and procaspase-8 form heterodimer
R-HSA-9013895 Caspase-8 processing within TLR3 complex
R-HSA-622420 NOD1 induced apoptosis is mediated by RIP2 and CARD8
R-HSA-933523 Dimerzation of procaspase-8, procaspase-10
R-HSA-933526 Recruitment of caspase-8 and -10 to FADD complex
R-HSA-351863 Translocation of active caspase-8 to the mitochondrial membrane
R-HSA-2672196 Viral serpin blocks caspase-8 activity
R-HSA-5660665 Caspase-8 binds MALT
R-HSA-139898 Caspase-8 activates BID by cleavage
R-HSA-201637 Caspase-mediated cleavage of plectin-1
R-HSA-350319 Caspase mediated cleavage of vimentin at IDVD (259)
R-HSA-5660662 ASC binds Caspase-8 complex
R-HSA-351894 Caspase mediated cleavage of BAP31
R-HSA-933539 Recruitment of IKK complex
R-HSA-5660663 Caspase-8 cleaves IL1B precursor
R-HSA-69416 Dimerization of procaspase-8
R-HSA-75158 TRAIL signaling
R-HSA-5357786 TNFR1-induced proapoptotic signaling
R-HSA-75157 FasL/ CD95L signaling
R-HSA-2562578 TRIF-mediated programmed cell death
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-9013957 TLR3-mediated TICAM1-dependent programmed cell death
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
R-HSA-3371378 Regulation by c-FLIP
R-HSA-140534 Ligand-dependent caspase activation
R-HSA-5218900 CASP8 activity is inhibited
R-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-73887 Death Receptor Signalling
R-HSA-75893 TNF signaling
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway
R-HSA-5675482 Regulation of necroptotic cell death
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-162582 Signal Transduction
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-168898 Toll-Like Receptors Cascades
R-HSA-75153 Apoptotic execution phase
R-HSA-5660668 CLEC7A/inflammasome pathway
R-HSA-168249 Innate Immune System
R-HSA-109581 Apoptosis
R-HSA-5213460 RIPK1-mediated regulated necrosis
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-75108 Activation, myristolyation of BID and translocation to mitochondria
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-168256 Immune System
R-HSA-111465 Apoptotic cleavage of cellular proteins
R-HSA-5357801 Programmed Cell Death
R-HSA-5218859 Regulated Necrosis
R-HSA-109606 Intrinsic Pathway for Apoptosis
R-HSA-5621481 C-type lectin receptors (CLRs)

-  Other Names for This Gene
  Alternate Gene Symbols: CASP8 , CASP8_HUMAN, MCH5 , NR_174602, O14676, Q14790, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81, uc329xhn.1, uc329xhn.2
UCSC ID: ENST00000673742.1_7
RefSeq Accession: NM_001372051.1
Protein: Q14790 (aka CASP8_HUMAN or ICE8_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.