Human Gene CAT (ENST00000241052.5_4) from GENCODE V47lift37
Description: catalase (from RefSeq NM_001752.4)
Gencode Transcript: ENST00000241052.5_4
Gencode Gene: ENSG00000121691.7_9
Transcript (Including UTRs)
Position: hg19 chr11:34,460,481-34,493,607 Size: 33,127 Total Exon Count: 13 Strand: +
Coding Region
Position: hg19 chr11:34,460,561-34,492,980 Size: 32,420 Coding Exon Count: 13
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: CATA_HUMAN
DESCRIPTION: RecName: Full=Catalase; EC=1.11.1.6;
FUNCTION: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.CATALYTIC ACTIVITY: 2 H(2)O(2) = O(2) + 2 H(2)O.COFACTOR: Heme group.COFACTOR: NADP.SUBUNIT: Homotetramer.SUBCELLULAR LOCATION: Peroxisome.PTM: The N-terminus is blocked.DISEASE: Defects in CAT are the cause of acatalasemia (ACATLAS) [MIM:614097] . A metabolic disorder characterized by absence of catalase activity in red cells and is often associated with ulcerating oral lesions.SIMILARITY: Belongs to the catalase family.WEB RESOURCE: Name=Wikipedia; Note=Catalase entry; URL="http://en.wikipedia.org/wiki/Catalase";WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cat/";
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: CAT
Diseases sorted by gene-association score: acatalasemia * (1398), pityriasis versicolor (25), pneumoconiosis (25), meningitis and encephalitis (18), urogenital tuberculosis (18), congenital rubella (18), refsum disease (11), favism (10), chronic granulomatous disease (10), avascular necrosis of the femoral head (9), diabetic angiopathy (9), toxic optic neuropathy (8), myeloperoxidase deficiency (8), tympanosclerosis (8), vitiligo-associated multiple autoimmune disease susceptibility 1 (8), gonadoblastoma (7), aniridia (7), wilson disease (7), hypermethioninemia (7), renovascular hypertension (7), retinal ischemia (7), neonatal adrenoleukodystrophy (7), peroxisome biogenesis disorder 1b (7), acne (6), microcytic anemia (6), cryptosporidiosis (6), myocardial stunning (6), d-bifunctional protein deficiency (6), bacteriuria (6), peroxisome disorders (5), spermatic cord torsion (5), peroxisomal biogenesis disorders (5), asbestosis (5), peroxisomal acyl-coa oxidase deficiency (5), hyperphenylalaninemia (5), type 1 diabetes mellitus 10 (5), breast abscess (4), valproate embryopathy, susceptibility to (4), rhizomelic chondrodysplasia punctata, type 2 (4), deficiency anemia (3), alzheimer disease (3), lateral sclerosis (3), vascular disease (2), breast disease (2), asthma (2), oral cavity cancer (2), diabetes mellitus, insulin-dependent (1), parkinson disease, late-onset (1), tetralogy of fallot (1)* = Manually curated disease association
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR018028 - Catalase
IPR020835 - Catalase-like_dom
IPR024708 - Catalase_AS
IPR024711 - Catalase_clade1/3
IPR011614 - Catalase_core
IPR002226 - Catalase_haem_BS
IPR010582 - Catalase_immune_responsive
Pfam Domains: PF00199 - Catalase
PF06628 - Catalase-related immune-responsive
SCOP Domains: 56634 - Heme-dependent catalase-like
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on P04040
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
KJ890831 - Synthetic construct Homo sapiens clone ccsbBroadEn_00225 CAT gene, encodes complete protein.KR711567 - Synthetic construct Homo sapiens clone CCSBHm_00026863 CAT (CAT) mRNA, encodes complete protein.KR711568 - Synthetic construct Homo sapiens clone CCSBHm_00026864 CAT (CAT) mRNA, encodes complete protein.KR711569 - Synthetic construct Homo sapiens clone CCSBHm_00026865 CAT (CAT) mRNA, encodes complete protein.LF205797 - JP 2014500723-A/13300: Polycomb-Associated Non-Coding RNAs.AK291585 - Homo sapiens cDNA FLJ78138 complete cds, highly similar to Homo sapiens catalase (CAT), mRNA.BC110398 - Homo sapiens catalase, mRNA (cDNA clone MGC:117400 IMAGE:5551309), complete cds.AK315350 - Homo sapiens cDNA, FLJ96395, highly similar to Homo sapiens catalase (CAT), mRNA.X04076 - Human kidney mRNA for catalase.BC112217 - Homo sapiens catalase, mRNA (cDNA clone MGC:138422 IMAGE:8327685), complete cds.BC112219 - Homo sapiens catalase, mRNA (cDNA clone MGC:138424 IMAGE:8327687), complete cds.GQ891493 - Homo sapiens clone HEL-S-214 epididymis secretory sperm binding protein mRNA, complete cds.AB587573 - Synthetic construct DNA, clone: pF1KE1962, Homo sapiens CAT gene for catalase, without stop codon, in Flexi system.E01497 - cDNA encoding human catalase.HQ258304 - Synthetic construct Homo sapiens clone IMAGE:100072613 catalase (CAT) gene, encodes complete protein.AY028632 - Homo sapiens catalase (CAT) mRNA, complete cds.AK301577 - Homo sapiens cDNA FLJ60361 complete cds, highly similar to Catalase (EC 1.11.1.6).AK310184 - Homo sapiens cDNA, FLJ17226.MA441374 - JP 2018138019-A/13300: Polycomb-Associated Non-Coding RNAs.LF348344 - JP 2014500723-A/155847: Polycomb-Associated Non-Coding RNAs.MA583921 - JP 2018138019-A/155847: Polycomb-Associated Non-Coding RNAs.JD026241 - Sequence 7265 from Patent EP1572962.JD019536 - Sequence 560 from Patent EP1572962.JD030140 - Sequence 11164 from Patent EP1572962.LF348339 - JP 2014500723-A/155842: Polycomb-Associated Non-Coding RNAs.LF348337 - JP 2014500723-A/155840: Polycomb-Associated Non-Coding RNAs.BC027300 - Homo sapiens, Similar to catalase, clone IMAGE:3924219, mRNA, partial cds.CS121466 - Sequence 1 from Patent WO2005056048.AK022134 - Homo sapiens cDNA FLJ12072 fis, clone HEMBB1002371.LF348330 - JP 2014500723-A/155833: Polycomb-Associated Non-Coding RNAs.LF348329 - JP 2014500723-A/155832: Polycomb-Associated Non-Coding RNAs.LQ021078 - Sequence 21 from Patent WO2015144924.CS121468 - Sequence 3 from Patent WO2005056048.JD020498 - Sequence 1522 from Patent EP1572962.JD028368 - Sequence 9392 from Patent EP1572962.JD197232 - Sequence 178256 from Patent EP1572962.MA583916 - JP 2018138019-A/155842: Polycomb-Associated Non-Coding RNAs.MA583914 - JP 2018138019-A/155840: Polycomb-Associated Non-Coding RNAs.MA583907 - JP 2018138019-A/155833: Polycomb-Associated Non-Coding RNAs.MA583906 - JP 2018138019-A/155832: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: A8K6C0, B2RCZ9, CATA_HUMAN, D3DR07, ENST00000241052.1, ENST00000241052.2, ENST00000241052.3, ENST00000241052.4, NM_001752, P04040, Q2M1U4, Q4VXX5, Q9BWT9, Q9UC85, uc317eij.1, uc317eij.2UCSC ID: ENST00000241052.5_4RefSeq Accession: NM_001752.4
Protein: P04040
(aka CATA_HUMAN)
Gene Model Information
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Methods, Credits, and Use Restrictions
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