ID:CBR1_HUMAN DESCRIPTION: RecName: Full=Carbonyl reductase [NADPH] 1; EC=1.1.1.184; AltName: Full=15-hydroxyprostaglandin dehydrogenase [NADP(+)]; EC=1.1.1.197; AltName: Full=NADPH-dependent carbonyl reductase 1; AltName: Full=Prostaglandin 9-ketoreductase; AltName: Full=Prostaglandin-E(2) 9-reductase; EC=1.1.1.189; FUNCTION: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. CATALYTIC ACTIVITY: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH. CATALYTIC ACTIVITY: (5Z,13E)-(15S)-9-alpha,11-alpha,15- trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11- alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. CATALYTIC ACTIVITY: (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost- 13-enoate + NADP(+) = (13E)-11-alpha-hydroxy-9,15-dioxoprost-13- enoate + NADPH. ENZYME REGULATION: Inhibited by quercetin, rutenin and its derivatives. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=30 uM for S-nitrosoglutathione; KM=22 uM for menadione; KM=309 uM for prostaglandin E2; KM=173 uM for daunorubicin; KM=247 uM for NADPH; SUBUNIT: Monomer. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cbr1/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P16152
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004090 carbonyl reductase (NADPH) activity GO:0016491 oxidoreductase activity GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0047021 15-hydroxyprostaglandin dehydrogenase (NADP+) activity GO:0050221 prostaglandin-E2 9-reductase activity
Biological Process: GO:0017144 drug metabolic process GO:0019371 cyclooxygenase pathway GO:0030855 epithelial cell differentiation GO:0042373 vitamin K metabolic process GO:0055114 oxidation-reduction process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
