Human Gene CCDC33 (ENST00000398814.8_6) from GENCODE V47lift37
  Description: coiled-coil domain containing 33, transcript variant 1 (from RefSeq NM_025055.5)
Gencode Transcript: ENST00000398814.8_6
Gencode Gene: ENSG00000140481.15_11
Transcript (Including UTRs)
   Position: hg19 chr15:74,528,667-74,628,482 Size: 99,816 Total Exon Count: 19 Strand: +
Coding Region
   Position: hg19 chr15:74,529,061-74,628,394 Size: 99,334 Coding Exon Count: 19 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:74,528,667-74,628,482)mRNA (may differ from genome)Protein (755 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CCD33_HUMAN
DESCRIPTION: RecName: Full=Coiled-coil domain-containing protein 33; AltName: Full=Cancer/testis antigen 61; Short=CT61;
INTERACTION: Q96ED9:HOOK2; NbExp=2; IntAct=EBI-740841, EBI-743290;
SIMILARITY: Contains 1 C2 domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.80 RPKM in Testis
Total median expression: 13.86 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -124.40394-0.316 Picture PostScript Text
3' UTR -22.2088-0.252 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000008 - C2_Ca-dep
IPR008973 - C2_Ca/lipid-bd_dom_CaLB

Pfam Domains:
PF00168 - C2 domain

SCOP Domains:
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)

ModBase Predicted Comparative 3D Structure on Q8N5R6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding


-  Descriptions from all associated GenBank mRNAs
  AK057417 - Homo sapiens cDNA FLJ32855 fis, clone TESTI2003512, weakly similar to SYNAPTONEMAL COMPLEX PROTEIN 1.
BC031684 - Homo sapiens coiled-coil domain containing 33, mRNA (cDNA clone IMAGE:5166443), partial cds.
DQ581642 - Homo sapiens piRNA piR-49754, complete sequence.
AK310852 - Homo sapiens cDNA, FLJ17894.
AK290709 - Homo sapiens cDNA FLJ78255 complete cds.
AK026821 - Homo sapiens cDNA: FLJ23168 fis, clone LNG09905.
BC025689 - Homo sapiens cDNA clone IMAGE:5207361, containing frame-shift errors.
CU693014 - Synthetic construct Homo sapiens gateway clone IMAGE:100019010 5' read CCDC33 mRNA.
KJ903277 - Synthetic construct Homo sapiens clone ccsbBroadEn_12671 CCDC33 gene, encodes complete protein.
JD413084 - Sequence 394108 from Patent EP1572962.
JD365380 - Sequence 346404 from Patent EP1572962.
JD368641 - Sequence 349665 from Patent EP1572962.
JD094590 - Sequence 75614 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K3U4, A8MPQ6, A8MV61, A8MVU9, B3KQ49, CCD33_HUMAN, ENST00000398814.1, ENST00000398814.2, ENST00000398814.3, ENST00000398814.4, ENST00000398814.5, ENST00000398814.6, ENST00000398814.7, NM_025055, Q8N5R6, Q8TAX6, Q9H5Q6, uc318zyt.1, uc318zyt.2
UCSC ID: ENST00000398814.8_6
RefSeq Accession: NM_025055.5
Protein: Q8N5R6 (aka CCD33_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.