Human Gene CCDC86 (ENST00000227520.10_5) from GENCODE V47lift37
  Description: coiled-coil domain containing 86 (from RefSeq NM_024098.4)
Gencode Transcript: ENST00000227520.10_5
Gencode Gene: ENSG00000110104.13_15
Transcript (Including UTRs)
   Position: hg19 chr11:60,609,586-60,618,554 Size: 8,969 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr11:60,609,598-60,617,798 Size: 8,201 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:60,609,586-60,618,554)mRNA (may differ from genome)Protein (360 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CCD86_HUMAN
DESCRIPTION: RecName: Full=Coiled-coil domain-containing protein 86; AltName: Full=Cytokine-induced protein with coiled-coil domain;
SUBUNIT: Interacts with hepatitis C virus (HCV) protein NS5A.
SUBCELLULAR LOCATION: Nucleus (By similarity).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.20 RPKM in Testis
Total median expression: 387.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -263.10756-0.348 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026570 - CCDC86

Pfam Domains:
PF03879 - Cgr1 family

ModBase Predicted Comparative 3D Structure on Q9H6F5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding

Biological Process:
GO:0016032 viral process

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  AK025974 - Homo sapiens cDNA: FLJ22321 fis, clone HRC05390.
AK302329 - Homo sapiens cDNA FLJ51395 complete cds.
AK123775 - Homo sapiens cDNA FLJ41781 fis, clone IMR322018117.
BC001378 - Homo sapiens coiled-coil domain containing 86, mRNA (cDNA clone MGC:2574 IMAGE:3051044), complete cds.
DQ892603 - Synthetic construct clone IMAGE:100005233; FLH188223.01X; RZPDo839H10150D coiled-coil domain containing 86 (CCDC86) gene, encodes complete protein.
DQ895844 - Synthetic construct Homo sapiens clone IMAGE:100010304; FLH188219.01L; RZPDo839H10149D coiled-coil domain containing 86 (CCDC86) gene, encodes complete protein.
KJ899526 - Synthetic construct Homo sapiens clone ccsbBroadEn_08920 CCDC86 gene, encodes complete protein.
DQ501251 - Homo sapiens cyclon mRNA, complete cds.
JD492397 - Sequence 473421 from Patent EP1572962.
JD099445 - Sequence 80469 from Patent EP1572962.
JD324698 - Sequence 305722 from Patent EP1572962.
JD118717 - Sequence 99741 from Patent EP1572962.
JD102659 - Sequence 83683 from Patent EP1572962.
JD062443 - Sequence 43467 from Patent EP1572962.
JD371485 - Sequence 352509 from Patent EP1572962.
JD337999 - Sequence 319023 from Patent EP1572962.
JD464294 - Sequence 445318 from Patent EP1572962.
JD164042 - Sequence 145066 from Patent EP1572962.
DQ587658 - Homo sapiens piRNA piR-54770, complete sequence.
JD226277 - Sequence 207301 from Patent EP1572962.
JD423765 - Sequence 404789 from Patent EP1572962.
JD271931 - Sequence 252955 from Patent EP1572962.
JD260302 - Sequence 241326 from Patent EP1572962.
JD512153 - Sequence 493177 from Patent EP1572962.
JD183258 - Sequence 164282 from Patent EP1572962.
JD171650 - Sequence 152674 from Patent EP1572962.
JD553568 - Sequence 534592 from Patent EP1572962.
JD392777 - Sequence 373801 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DY99, CCD86_HUMAN, CYCLON, ENST00000227520.1, ENST00000227520.2, ENST00000227520.3, ENST00000227520.4, ENST00000227520.5, ENST00000227520.6, ENST00000227520.7, ENST00000227520.8, ENST00000227520.9, NM_024098, Q9H6F5, uc317dmw.1, uc317dmw.2
UCSC ID: ENST00000227520.10_5
RefSeq Accession: NM_024098.4
Protein: Q9H6F5 (aka CCD86_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.