Human Gene CCK (ENST00000396169.7_7) from GENCODE V47lift37
  Description: cholecystokinin, transcript variant 1 (from RefSeq NM_000729.6)
Gencode Transcript: ENST00000396169.7_7
Gencode Gene: ENSG00000187094.12_9
Transcript (Including UTRs)
   Position: hg19 chr3:42,299,318-42,307,677 Size: 8,360 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr3:42,299,590-42,305,122 Size: 5,533 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:42,299,318-42,307,677)mRNA (may differ from genome)Protein (115 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q6FG82_HUMAN
DESCRIPTION: SubName: Full=CCK protein; SubName: Full=Cholecystokinin; SubName: Full=Cholecystokinin, isoform CRA_a; SubName: Full=cDNA FLJ76519, highly similar to Homo sapiens cholecystokinin (CCK), mRNA; Flags: Fragment;
SUBCELLULAR LOCATION: Secreted (By similarity).
SIMILARITY: Belongs to the gastrin/cholecystokinin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCK
Diseases sorted by gene-association score: biliary dyskinesia (36), cholecystitis (34), acalculous cholecystitis (26), gallbladder disease (25), bulimia nervosa (21), bile reflux (21), panic disorder (21), duodenogastric reflux (17), acute pancreatitis (17), morphine dependence (16), gastrointestinal system disease (16), cholelithiasis (16), exocrine pancreatic insufficiency (16), dyspepsia (14), pancreatitis (14), opioid abuse (13), gastroparesis (13), gastroesophageal reflux (12), irritable bowel syndrome (12), eating disorder (11), duodenal disease (11), social phobia (11), duodenal ulcer (10), anorexia nervosa (10), short bowel syndrome (10), headache (9), steatorrhea (9), alcoholic pancreatitis (9), constipation (8), autonomic neuropathy (8), postcholecystectomy syndrome (8), functional gastric disease (7), pancreas disease (7), diarrhea (7), anxiety disorder (7), morbid obesity (7), nasal cavity adenocarcinoma (7), neuroendocrine tumor (7), deafness, autosomal recessive 42 (7), pancreatitis, hereditary (6), common bile duct disease (6), pain agnosia (6), stereotypic movement disorder (6), agnosia (6), pancreatic cancer (6), cholecystolithiasis (6), rasmussen encephalitis (6), pancreatic steatorrhea (6), paralytic ileus (5), megalencephaly (5), duodenal gastrinoma (5), bile duct disease (5), achondrogenesis ib (5), ascending cholangitis (5), space motion sickness (5), stomach disease (5), pancreatic cholera (5), biliary tract disease (5), deafness, autosomal recessive 49 (5), obesity (4), cataract 14, multiple types (4), acute mountain sickness (4), celiac disease (3), medullary thyroid carcinoma, familial (2), alcohol dependence (2), schizophrenia (1), specific developmental disorder (1), disease of mental health (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 122.95 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 465.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -368.20884-0.417 Picture PostScript Text
3' UTR -56.40272-0.207 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015499 - CCK
IPR001651 - Gastrin
IPR013152 - Gastrin/cholecystokinin_CS

Pfam Domains:
PF00918 - Gastrin/cholecystokinin family

ModBase Predicted Comparative 3D Structure on Q6FG82
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity

Biological Process:
GO:0001662 behavioral fear response
GO:0001764 neuron migration
GO:0001836 release of cytochrome c from mitochondria
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007409 axonogenesis
GO:0008284 positive regulation of cell proliferation
GO:0010469 regulation of receptor activity
GO:0014049 positive regulation of glutamate secretion
GO:0032099 negative regulation of appetite
GO:0032461 positive regulation of protein oligomerization
GO:0042755 eating behavior
GO:0043065 positive regulation of apoptotic process
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051901 positive regulation of mitochondrial depolarization
GO:0051930 regulation of sensory perception of pain

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0043194 axon initial segment
GO:0043195 terminal bouton
GO:0043203 axon hillock
GO:0043204 perikaryon


-  Descriptions from all associated GenBank mRNAs
  LF208671 - JP 2014500723-A/16174: Polycomb-Associated Non-Coding RNAs.
BC111026 - Homo sapiens cholecystokinin, mRNA (cDNA clone MGC:117187 IMAGE:5199880), complete cds.
BC008283 - Homo sapiens cholecystokinin, mRNA (cDNA clone MGC:10571 IMAGE:3639109), complete cds.
BC093055 - Homo sapiens cholecystokinin, mRNA (cDNA clone MGC:111138 IMAGE:30722619), complete cds.
AK289716 - Homo sapiens cDNA FLJ76519 complete cds, highly similar to Homo sapiens cholecystokinin (CCK), mRNA.
LF378893 - JP 2014500723-A/186396: Polycomb-Associated Non-Coding RNAs.
JD415112 - Sequence 396136 from Patent EP1572962.
JD095478 - Sequence 76502 from Patent EP1572962.
JD470474 - Sequence 451498 from Patent EP1572962.
EU176479 - Synthetic construct Homo sapiens clone IMAGE:100011332; FLH164012.01L; RZPDo839B10161D cholecystokinin (CCK) gene, encodes complete protein.
EU176482 - Synthetic construct Homo sapiens clone IMAGE:100011612; FLH263886.01L; RZPDo839G05247D cholecystokinin (CCK) gene, encodes complete protein.
BT006991 - Homo sapiens cholecystokinin mRNA, complete cds.
DQ890568 - Synthetic construct clone IMAGE:100003198; FLH164016.01X; RZPDo839B10162D cholecystokinin (CCK) gene, encodes complete protein.
KJ890840 - Synthetic construct Homo sapiens clone ccsbBroadEn_00234 CCK gene, encodes complete protein.
CR542226 - Homo sapiens full open reading frame cDNA clone RZPDo834D1225D for gene CCK, cholecystokinin; complete cds, without stopcodon.
LF378894 - JP 2014500723-A/186397: Polycomb-Associated Non-Coding RNAs.
LF212325 - JP 2014500723-A/19828: Polycomb-Associated Non-Coding RNAs.
AK300784 - Homo sapiens cDNA FLJ51636 complete cds, moderately similar to Cholecystokinins precursor.
LF378897 - JP 2014500723-A/186400: Polycomb-Associated Non-Coding RNAs.
JD176844 - Sequence 157868 from Patent EP1572962.
JD056432 - Sequence 37456 from Patent EP1572962.
JD059228 - Sequence 40252 from Patent EP1572962.
JD175192 - Sequence 156216 from Patent EP1572962.
JD416865 - Sequence 397889 from Patent EP1572962.
JD214262 - Sequence 195286 from Patent EP1572962.
JD065167 - Sequence 46191 from Patent EP1572962.
JD384538 - Sequence 365562 from Patent EP1572962.
JD149706 - Sequence 130730 from Patent EP1572962.
JD075928 - Sequence 56952 from Patent EP1572962.
MA444248 - JP 2018138019-A/16174: Polycomb-Associated Non-Coding RNAs.
MA614470 - JP 2018138019-A/186396: Polycomb-Associated Non-Coding RNAs.
MA614471 - JP 2018138019-A/186397: Polycomb-Associated Non-Coding RNAs.
MA447902 - JP 2018138019-A/19828: Polycomb-Associated Non-Coding RNAs.
MA614474 - JP 2018138019-A/186400: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_fasPathway - FAS signaling pathway ( CD95 )

-  Other Names for This Gene
  Alternate Gene Symbols: A0A024R2P8, CCK , ENST00000396169.1, ENST00000396169.2, ENST00000396169.3, ENST00000396169.4, ENST00000396169.5, ENST00000396169.6, hCG_28858 , NM_000729, Q6FG82, Q6FG82_HUMAN, uc318yaw.1, uc318yaw.2
UCSC ID: ENST00000396169.7_7
RefSeq Accession: NM_000729.6
Protein: Q6FG82

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.