Human Gene CCKAR (ENST00000295589.4_7) from GENCODE V47lift37
  Description: cholecystokinin A receptor (from RefSeq NM_000730.3)
Gencode Transcript: ENST00000295589.4_7
Gencode Gene: ENSG00000163394.6_9
Transcript (Including UTRs)
   Position: hg19 chr4:26,483,018-26,492,106 Size: 9,089 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr4:26,483,260-26,491,889 Size: 8,630 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:26,483,018-26,492,106)mRNA (may differ from genome)Protein (428 aa)
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UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CCKAR_HUMAN
DESCRIPTION: RecName: Full=Cholecystokinin receptor type A; Short=CCK-A receptor; Short=CCK-AR; AltName: Full=Cholecystokinin-1 receptor; Short=CCK1-R;
FUNCTION: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
WEB RESOURCE: Name=Wikipedia; Note=Cholecystokinin receptor entry; URL="http://en.wikipedia.org/wiki/Cholecystokinin_receptor";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCKAR
Diseases sorted by gene-association score: panic disorder (11), gastrointestinal system disease (9), dyspepsia (8), exocrine pancreatic insufficiency (7), paranoid schizophrenia (7), gallbladder disease (7), cholelithiasis (6), pancreatic cancer (4), acute pancreatitis (4), obesity (1), schizophrenia (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.72 RPKM in Stomach
Total median expression: 9.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -79.70217-0.367 Picture PostScript Text
3' UTR -77.80242-0.321 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR009126 - Cholcskin_rcpt
IPR000596 - Cholcy_rcpt_A
IPR015276 - CholecystokininA_recpt_N
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF09193 - Cholecystokinin A receptor, N-terminal
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx
PF13853 - Olfactory receptor

SCOP Domains:
81321 - Family A G protein-coupled receptor-like
57642 - Cholecystokinin A receptor, N-domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1D6G - NMR 1HZN - NMR 1PB2 - Model


ModBase Predicted Comparative 3D Structure on P32238
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004951 cholecystokinin receptor activity
GO:0017046 peptide hormone binding
GO:0042277 peptide binding

Biological Process:
GO:0001764 neuron migration
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007409 axonogenesis
GO:0030900 forebrain development
GO:0032870 cellular response to hormone stimulus
GO:0038188 cholecystokinin signaling pathway
GO:0046883 regulation of hormone secretion
GO:1901652 response to peptide

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  L19315 - Human cholecystokinin A receptor mRNA, complete cds.
JD155331 - Sequence 136355 from Patent EP1572962.
JD103859 - Sequence 84883 from Patent EP1572962.
JD436292 - Sequence 417316 from Patent EP1572962.
JD061917 - Sequence 42941 from Patent EP1572962.
JD328376 - Sequence 309400 from Patent EP1572962.
JD340182 - Sequence 321206 from Patent EP1572962.
JD178417 - Sequence 159441 from Patent EP1572962.
JD186023 - Sequence 167047 from Patent EP1572962.
JD056162 - Sequence 37186 from Patent EP1572962.
JD469044 - Sequence 450068 from Patent EP1572962.
BC074987 - Homo sapiens cholecystokinin A receptor, mRNA (cDNA clone MGC:104068 IMAGE:30915519), complete cds.
JD420332 - Sequence 401356 from Patent EP1572962.
L13605 - Human cholecystokinin A receptor mRNA, complete cds.
JD124044 - Sequence 105068 from Patent EP1572962.
JD193197 - Sequence 174221 from Patent EP1572962.
JD266855 - Sequence 247879 from Patent EP1572962.
AY322549 - Homo sapiens cholecystokinin A receptor mRNA, complete cds.
AK313978 - Homo sapiens cDNA, FLJ94628, Homo sapiens cholecystokinin A receptor (CCKAR), mRNA.
AB528043 - Synthetic construct DNA, clone: pF1KE0687, Homo sapiens CCKAR gene for cholecystokinin A receptor, without stop codon, in Flexi system.
JD287275 - Sequence 268299 from Patent EP1572962.
JD164399 - Sequence 145423 from Patent EP1572962.
JD456566 - Sequence 437590 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P32238 (Reactome details) participates in the following event(s):

R-HSA-388529 Cholecystokinin receptors bind cholecystokinin
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2R9Z5, CCKAR_HUMAN, CCKRA, ENST00000295589.1, ENST00000295589.2, ENST00000295589.3, NM_000730, P32238, uc317lml.1, uc317lml.2
UCSC ID: ENST00000295589.4_7
RefSeq Accession: NM_000730.3
Protein: P32238 (aka CCKAR_HUMAN or CCKR_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.