Human Gene CCL15 (ENST00000617897.2_9) from GENCODE V47lift37
  Description: C-C motif chemokine ligand 15 (from RefSeq NM_032965.6)
Gencode Transcript: ENST00000617897.2_9
Gencode Gene: ENSG00000275718.2_13
Transcript (Including UTRs)
   Position: hg19 chr17:34,324,618-34,328,592 Size: 3,975 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr17:34,324,803-34,328,531 Size: 3,729 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:34,324,618-34,328,592)mRNA (may differ from genome)Protein (113 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CCL15_HUMAN
DESCRIPTION: RecName: Full=C-C motif chemokine 15; AltName: Full=Chemokine CC-2; Short=HCC-2; AltName: Full=Leukotactin-1; Short=LKN-1; AltName: Full=MIP-1 delta; AltName: Full=Macrophage inflammatory protein 5; Short=MIP-5; AltName: Full=Mrp-2b; AltName: Full=NCC-3; AltName: Full=Small-inducible cytokine A15; Contains: RecName: Full=CCL15(22-92); Contains: RecName: Full=CCL15(25-92); Contains: RecName: Full=CCL15(29-92); Flags: Precursor;
FUNCTION: Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients.
SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
WEB RESOURCE: Name=Wikipedia; Note=CCL15 entry; URL="http://en.wikipedia.org/wiki/CCL15";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCL15
Diseases sorted by gene-association score: hepatocellular carcinoma (5), gastrointestinal system cancer (3), spherocytosis, type 5 (2), eyelid disease (2), respiratory system disease (2), bile duct adenocarcinoma (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.2061-0.380 Picture PostScript Text
3' UTR -22.80185-0.123 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000827 - Chemokine_CC_CS
IPR001811 - Chemokine_IL8-like_dom

Pfam Domains:
PF00048 - Small cytokines (intecrine/chemokine), interleukin-8 like

SCOP Domains:
54117 - Interleukin 8-like chemokines

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2HCC - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q16663
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0008009 chemokine activity
GO:0008201 heparin binding
GO:0042056 chemoattractant activity
GO:0048020 CCR chemokine receptor binding

Biological Process:
GO:0002548 monocyte chemotaxis
GO:0006874 cellular calcium ion homeostasis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0010469 regulation of receptor activity
GO:0030593 neutrophil chemotaxis
GO:0043547 positive regulation of GTPase activity
GO:0048247 lymphocyte chemotaxis
GO:0050918 positive chemotaxis
GO:0060326 cell chemotaxis
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005623 cell


-  Descriptions from all associated GenBank mRNAs
  Z70292 - H.sapiens mRNA for chemokine CC-2 and CC-1.
Z70293 - H.sapiens mRNA for chemokine CC-2 and CC-3.
BC140941 - Homo sapiens chemokine (C-C motif) ligand 15, mRNA (cDNA clone MGC:176618 IMAGE:9056753), complete cds.
U58914 - Human chemokine (hmrp-2b) mRNA, complete cds.
AF031587 - Homo sapiens MIP-1 delta mRNA, complete cds.
JD315962 - Sequence 296986 from Patent EP1572962.
JD315963 - Sequence 296987 from Patent EP1572962.
KJ897525 - Synthetic construct Homo sapiens clone ccsbBroadEn_06919 CCL15 gene, encodes complete protein.
AB463484 - Synthetic construct DNA, clone: pF1KB6763, Homo sapiens CCL15 gene for chemokine (C-C motif) ligand 15, without stop codon, in Flexi system.
JD231746 - Sequence 212770 from Patent EP1572962.
JD385296 - Sequence 366320 from Patent EP1572962.
JD231745 - Sequence 212769 from Patent EP1572962.
JD036860 - Sequence 17884 from Patent EP1572962.
JD272632 - Sequence 253656 from Patent EP1572962.
JD163320 - Sequence 144344 from Patent EP1572962.
JD268131 - Sequence 249155 from Patent EP1572962.
JD498973 - Sequence 479997 from Patent EP1572962.
JD192498 - Sequence 173522 from Patent EP1572962.
JD144376 - Sequence 125400 from Patent EP1572962.
JD150058 - Sequence 131082 from Patent EP1572962.
JD456618 - Sequence 437642 from Patent EP1572962.
JD180641 - Sequence 161665 from Patent EP1572962.
JD080900 - Sequence 61924 from Patent EP1572962.
JD086083 - Sequence 67107 from Patent EP1572962.
JD510352 - Sequence 491376 from Patent EP1572962.
JD226135 - Sequence 207159 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RU34, CCL15_HUMAN, E1P651, ENST00000617897.1, MIP5, NCC3, NM_032965, Q16663, Q9UM74, SCYA15, uc327rjg.1, uc327rjg.2
UCSC ID: ENST00000617897.2_9
RefSeq Accession: NM_032965.6
Protein: Q16663 (aka CCL15_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.