Human Gene CCL2 (ENST00000225831.4_5) from GENCODE V47lift37
  Description: C-C motif chemokine ligand 2 (from RefSeq NM_002982.4)
Gencode Transcript: ENST00000225831.4_5
Gencode Gene: ENSG00000108691.10_8
Transcript (Including UTRs)
   Position: hg19 chr17:32,582,304-32,584,222 Size: 1,919 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr17:32,582,369-32,583,846 Size: 1,478 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:32,582,304-32,584,222)mRNA (may differ from genome)Protein (99 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCL2
Diseases sorted by gene-association score: neural tube defects* (288), hiv-1* (206), atherosclerosis (47), proliferative glomerulonephritis (26), arthritis (24), rheumatoid arthritis (22), xanthogranulomatous pyelonephritis (18), herpes simplex virus keratitis (18), vangl1-related neural tube defect (18), anthracosis (17), crescentic glomerulonephritis (17), urinary tract obstruction (17), peritonitis (17), acute cystitis (15), arteriosclerosis (14), diabetic macular edema (13), chagas disease (13), psoriasis (13), trypanosomiasis (12), retinal vasculitis (12), mesangial proliferative glomerulonephritis (11), demyelinating disease (11), kawasaki disease (11), renal fibrosis (10), denture stomatitis (10), verruciform xanthoma of skin (10), interstitial lung disease (10), diabetic angiopathy (10), erdheim-chester disease (10), extrapulmonary tuberculosis (9), cerebral aneurysms (9), glomerulonephritis (9), uveitis (9), encephalitis (9), scleritis (9), pulmonary alveolar proteinosis (9), nephrosclerosis (9), endometriosis (9), temporal arteritis (9), pneumoconiosis (8), retinal vein occlusion (8), severe acute respiratory syndrome (8), viral encephalitis (8), mast-cell leukemia (8), pneumonia (8), abdominal aortic aneurysm (8), viral meningitis (8), tuberculous meningitis (8), pulmonary sarcoidosis (8), hydronephrosis (8), carotid artery disease (7), idiopathic interstitial pneumonia (7), hyperhomocysteinemia (7), alcoholic hepatitis (7), vascular disease (7), post-thrombotic syndrome (7), acute proliferative glomerulonephritis (7), lipoid nephrosis (7), pleural tuberculosis (7), autoinflammation, lipodystrophy, and dermatosis syndrome (7), pleurisy (7), retinitis pigmentosa 73 (7), pyelonephritis (7), endocervicitis (7), microvascular complications of diabetes 1 (7), pelvic inflammatory disease (7), complex regional pain syndrome (6), silicosis (6), anterior uveitis (6), dengue shock syndrome (6), chorioamnionitis (6), vitreoretinopathy, neovascular inflammatory (6), peripheral artery disease (6), purulent labyrinthitis (6), leptospirosis (6), stachybotrys chartarum (6), neuritis (6), keratitis (6), transient cerebral ischemia (6), bone cancer (6), nonspecific interstitial pneumonia (6), israeli tick typhus (6), radiculopathy (5), systemic lupus erythematosus (5), pulmonary fibrosis, idiopathic (5), stromal keratitis (5), retinal vascular occlusion (5), primary cutaneous amyloidosis (5), malaria (5), ischemic heart disease (5), extrinsic allergic alveolitis (5), sarcoidosis 1 (5), ureteral disease (4), macular holes (4), pulmonary fibrosis (4), coronary artery aneurysm (4), lung disease (4), obesity (4), macular retinal edema (4), extrinsic cardiomyopathy (4), vasculitis (4), periodontitis (3), eye disease (3), relapsing-remitting multiple sclerosis (3), meningitis (3), cystitis (3), artery disease (2), central nervous system disease (2), macular degeneration, age-related, 1 (2), multiple sclerosis, disease progression, modifier of (2), diabetes mellitus, noninsulin-dependent (2), urinary system disease (1), myocardial infarction (1), endometrial stromal sarcoma (1), overnutrition (1), respiratory system disease (1), bone inflammation disease (1), acquired metabolic disease (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 65.63 RPKM in Adipose - Visceral (Omentum)
Total median expression: 793.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -12.7065-0.195 Picture PostScript Text
3' UTR -67.40376-0.179 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00048 - Small cytokines (intecrine/chemokine), interleukin-8 like

SCOP Domains:
54117 - Interleukin 8-like chemokines

ModBase Predicted Comparative 3D Structure on Q6UZ82
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LF209225 - JP 2014500723-A/16728: Polycomb-Associated Non-Coding RNAs.
HW061215 - JP 2012529430-A/90: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
JB252023 - Sequence 90 from Patent EP2440214.
LP764922 - Sequence 90 from Patent EP3276004.
HW286096 - JP 2013143917-A/2: CURATIVE OR PREVENTIVE AGENT FOR FIBROSIS.
LX148401 - JP 2017079741-A/2: CURATIVE OR PREVENTIVE AGENT FOR FIBROSIS.
LP880256 - Sequence 60 from Patent WO2017181111.
LP882087 - Sequence 29 from Patent WO2017181079.
LQ878889 - Sequence 4 from Patent WO2018154075.
M24545 - Human monocyte chemotactic and activating factor (MCAF) mRNA, complete cds.
AK311308 - Homo sapiens cDNA, FLJ18350.
AK311960 - Homo sapiens cDNA, FLJ92229, Homo sapiens chemokine (C-C motif) ligand 2 (CCL2), mRNA.
FW339992 - Screening.
BC009716 - Homo sapiens chemokine (C-C motif) ligand 2, mRNA (cDNA clone MGC:9434 IMAGE:3901489), complete cds.
X14768 - H.sapiens mRNA for monocyte chemoattractant protein 1 (MCP-1).
S71513 - monocyte chemoattractant protein-1 [human, mRNA, 739 nt].
M28226 - Human JE gene encoding a monocyte secretory protein mRNA, complete cds.
S69738 - MCP-1=monocyte chemotactic protein [human, aortic endothelial cells, mRNA, 661 nt].
DQ893725 - Synthetic construct Homo sapiens clone IMAGE:100008185; FLH163964.01L; RZPDo839B04161D chemokine (C-C motif) ligand 2 (CCL2) gene, encodes complete protein.
EU176175 - Synthetic construct Homo sapiens clone IMAGE:100006330; FLH163971.01X; RZPDo839D02250D chemokine (C-C motif) ligand 2 (CCL2) gene, encodes complete protein.
JD383231 - Sequence 364255 from Patent EP1572962.
KJ892101 - Synthetic construct Homo sapiens clone ccsbBroadEn_01495 CCL2 gene, encodes complete protein.
KJ905313 - Synthetic construct Homo sapiens clone ccsbBroadEn_14837 CCL2 gene, encodes complete protein.
AB463485 - Synthetic construct DNA, clone: pF1KB6743, Homo sapiens CCL2 gene for chemokine (C-C motif) ligand 2, without stop codon, in Flexi system.
BT007329 - Homo sapiens chemokine (C-C motif) ligand 2 mRNA, complete cds.
E02542 - cDNA encoding human monocyte chemotactic factor.
E03044 - cDNA encoding human macrophage chemotaxis factor precursor.
M26683 - Human interferon gamma treatment inducible mRNA.
LF326991 - JP 2014500723-A/134494: Polycomb-Associated Non-Coding RNAs.
LF326993 - JP 2014500723-A/134496: Polycomb-Associated Non-Coding RNAs.
JD095969 - Sequence 76993 from Patent EP1572962.
LF326994 - JP 2014500723-A/134497: Polycomb-Associated Non-Coding RNAs.
JD297657 - Sequence 278681 from Patent EP1572962.
LF326995 - JP 2014500723-A/134498: Polycomb-Associated Non-Coding RNAs.
MA562568 - JP 2018138019-A/134494: Polycomb-Associated Non-Coding RNAs.
MA562570 - JP 2018138019-A/134496: Polycomb-Associated Non-Coding RNAs.
MA562571 - JP 2018138019-A/134497: Polycomb-Associated Non-Coding RNAs.
MA562572 - JP 2018138019-A/134498: Polycomb-Associated Non-Coding RNAs.
MA444802 - JP 2018138019-A/16728: Polycomb-Associated Non-Coding RNAs.
MB143804 - JP 2019515670-A/15: METHODS FOR MONITORING AND TREATING CANCER.
MB423127 - JP 2019521641-A/14: METHODS FOR MONITORING AND TREATING CANCER.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_Ccr5Pathway - Pertussis toxin-insensitive CCR5 Signaling in Macrophage
h_mspPathway - Msp/Ron Receptor Signaling Pathway
h_LDLpathway - Low-density lipoprotein (LDL) pathway during atherogenesis

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000225831.1, ENST00000225831.2, ENST00000225831.3, MCP1 , NM_002982, Q6UZ82, Q6UZ82_HUMAN, uc317dkh.1, uc317dkh.2
UCSC ID: ENST00000225831.4_5
RefSeq Accession: NM_002982.4
Protein: Q6UZ82

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.