Human Gene CCL5 (ENST00000605140.6_7) from GENCODE V47lift37
  Description: C-C motif chemokine ligand 5, transcript variant 1 (from RefSeq NM_002985.3)
Gencode Transcript: ENST00000605140.6_7
Gencode Gene: ENSG00000271503.7_11
Transcript (Including UTRs)
   Position: hg19 chr17:34,198,495-34,207,364 Size: 8,870 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr17:34,199,381-34,207,309 Size: 7,929 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:34,198,495-34,207,364)mRNA (may differ from genome)Protein (91 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CCL5_HUMAN
DESCRIPTION: RecName: Full=C-C motif chemokine 5; AltName: Full=EoCP; AltName: Full=Eosinophil chemotactic cytokine; AltName: Full=SIS-delta; AltName: Full=Small-inducible cytokine A5; AltName: Full=T cell-specific protein P228; Short=TCP228; AltName: Full=T-cell-specific protein RANTES; Contains: RecName: Full=RANTES(3-68); Contains: RecName: Full=RANTES(4-68); Flags: Precursor;
FUNCTION: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T- cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: T-cell and macrophage specific.
INDUCTION: By mitogens.
PTM: N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.
PTM: The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.
MASS SPECTROMETRY: Mass=7515; Mass_error=1; Method=SELDI; Range=27-91; Source=PubMed:15923218;
MASS SPECTROMETRY: Mass=7862.8; Mass_error=1.1; Method=Electrospray; Range=24-91; Source=PubMed:1380064;
MASS SPECTROMETRY: Mass=8355; Mass_error=10; Method=Electrospray; Range=24-91; Note=O-glycosylated; Source=PubMed:1380064;
POLYMORPHISM: The variant Phe-24 is an antagonist of the chemokine receptors CCR1 and CCR3.
SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccl5/";
WEB RESOURCE: Name=Wikipedia; Note=RANTES entry; URL="http://en.wikipedia.org/wiki/RANTES";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCL5
Diseases sorted by gene-association score: ulcer of lower limbs (22), periapical granuloma (18), whiplash (18), viral meningitis (17), common cold (16), genital herpes (16), bronchiolitis (14), scorpion envenomation (13), mycetoma (12), mast-cell leukemia (12), neuritis (11), chronic eosinophilic pneumonia (11), african tick-bite fever (11), yellow fever (11), respiratory syncytial virus infectious disease (11), vernal keratoconjunctivitis (10), omsk hemorrhagic fever (9), kimura disease (9), eosinophilic pneumonia (9), maxillary sinusitis (9), allergic asthma (9), pulmonary eosinophilia (9), mastitis (8), relapsing-remitting multiple sclerosis (8), dengue disease (8), griscelli syndrome, type 2 (8), interstitial lung disease (8), status asthmaticus (8), japanese encephalitis (8), griscelli syndrome (8), encephalitis (8), severe acute respiratory syndrome (8), vulvovaginitis (8), onchocerciasis (8), spotted fever (7), tropical spastic paraparesis (7), rhinitis (7), viral encephalitis (7), chikungunya (7), oral lichen planus (7), radiculopathy (7), gastrointestinal allergy (7), pulmonary sarcoidosis (6), stachybotrys chartarum (6), meningoencephalitis (6), orofacial granulomatosis (6), temporal arteritis (6), filariasis (6), asthma (6), epidemic typhus (6), acute cervicitis (6), rabies (6), folliculitis (6), avoidant personality disorder (5), stevens-johnson syndrome/toxic epidermal necrolysis (5), extrinsic allergic alveolitis (5), cytomegalovirus infection (5), human immunodeficiency virus infectious disease (5), rheumatoid arthritis (5), polyradiculoneuropathy (5), hiv-1 (5), chronic conjunctivitis (5), eumycotic mycetoma (4), bullous skin disease (4), influenza (4), idiopathic neutropenia (4), bronchial disease (4), inclusion conjunctivitis (4), chronic nk-cell lymphocytosis (4), meningococcemia (4), lung disease (3), endometriosis (3), viral infectious disease (3), pneumonia (3), systemic lupus erythematosus (3), b-cell expansion with nfkb and t-cell anergy (3), malaria (3), trypanosomiasis (3), demyelinating disease (2), multiple sclerosis, disease progression, modifier of (2), autoinflammation, lipodystrophy, and dermatosis syndrome (2), eye disease (2), sarcoidosis 1 (2), respiratory system disease (2), myocardial infarction (1), pulmonary fibrosis, idiopathic (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -10.8055-0.196 Picture PostScript Text
3' UTR -309.10886-0.349 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000827 - Chemokine_CC_CS
IPR001811 - Chemokine_IL8-like_dom

Pfam Domains:
PF00048 - Small cytokines (intecrine/chemokine), interleukin-8 like

SCOP Domains:
54117 - Interleukin 8-like chemokines

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1B3A - X-ray 1EQT - X-ray MuPIT 1HRJ - NMR MuPIT 1RTN - NMR MuPIT 1RTO - NMR MuPIT 1U4L - X-ray MuPIT 1U4M - X-ray MuPIT 1U4P - X-ray MuPIT 1U4R - X-ray MuPIT 2L9H - Other MuPIT 2VXW - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P13501
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004672 protein kinase activity
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008009 chemokine activity
GO:0016004 phospholipase activator activity
GO:0030298 receptor signaling protein tyrosine kinase activator activity
GO:0031726 CCR1 chemokine receptor binding
GO:0031729 CCR4 chemokine receptor binding
GO:0031730 CCR5 chemokine receptor binding
GO:0042056 chemoattractant activity
GO:0042379 chemokine receptor binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043621 protein self-association
GO:0046817 chemokine receptor antagonist activity

Biological Process:
GO:0000165 MAPK cascade
GO:0002407 dendritic cell chemotaxis
GO:0002548 monocyte chemotaxis
GO:0002676 regulation of chronic inflammatory response
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006887 exocytosis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007159 leukocyte cell-cell adhesion
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0009615 response to virus
GO:0009636 response to toxic substance
GO:0010469 regulation of receptor activity
GO:0010536 positive regulation of activation of Janus kinase activity
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010820 positive regulation of T cell chemotaxis
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014911 positive regulation of smooth muscle cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0030335 positive regulation of cell migration
GO:0030593 neutrophil chemotaxis
GO:0031328 positive regulation of cellular biosynthetic process
GO:0031584 activation of phospholipase D activity
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0033634 positive regulation of cell-cell adhesion mediated by integrin
GO:0034097 response to cytokine
GO:0034112 positive regulation of homotypic cell-cell adhesion
GO:0034612 response to tumor necrosis factor
GO:0042102 positive regulation of T cell proliferation
GO:0042119 neutrophil activation
GO:0042327 positive regulation of phosphorylation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043491 protein kinase B signaling
GO:0043547 positive regulation of GTPase activity
GO:0043922 negative regulation by host of viral transcription
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045070 positive regulation of viral genome replication
GO:0045071 negative regulation of viral genome replication
GO:0045089 positive regulation of innate immune response
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0045785 positive regulation of cell adhesion
GO:0045948 positive regulation of translational initiation
GO:0046427 positive regulation of JAK-STAT cascade
GO:0048245 eosinophil chemotaxis
GO:0048246 macrophage chemotaxis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050796 regulation of insulin secretion
GO:0050863 regulation of T cell activation
GO:0050918 positive chemotaxis
GO:0051262 protein tetramerization
GO:0051928 positive regulation of calcium ion transport
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070098 chemokine-mediated signaling pathway
GO:0070100 negative regulation of chemokine-mediated signaling pathway
GO:0070233 negative regulation of T cell apoptotic process
GO:0070234 positive regulation of T cell apoptotic process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071407 cellular response to organic cyclic compound
GO:0090026 positive regulation of monocyte chemotaxis
GO:1901214 regulation of neuron death
GO:2000110 negative regulation of macrophage apoptotic process
GO:2000406 positive regulation of T cell migration
GO:2000503 positive regulation of natural killer cell chemotaxis

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  KJ892104 - Synthetic construct Homo sapiens clone ccsbBroadEn_01498 CCL5 gene, encodes complete protein.
LF209233 - JP 2014500723-A/16736: Polycomb-Associated Non-Coding RNAs.
LP880258 - Sequence 62 from Patent WO2017181111.
LP882089 - Sequence 31 from Patent WO2017181079.
M21121 - Human T cell-specific protein (RANTES) mRNA, complete cds.
JD041604 - Sequence 22628 from Patent EP1572962.
JD095136 - Sequence 76160 from Patent EP1572962.
JD284715 - Sequence 265739 from Patent EP1572962.
JD444973 - Sequence 425997 from Patent EP1572962.
JD167381 - Sequence 148405 from Patent EP1572962.
JD338341 - Sequence 319365 from Patent EP1572962.
JD566093 - Sequence 547117 from Patent EP1572962.
JD049250 - Sequence 30274 from Patent EP1572962.
JD096806 - Sequence 77830 from Patent EP1572962.
JD143001 - Sequence 124025 from Patent EP1572962.
JD417231 - Sequence 398255 from Patent EP1572962.
JD162806 - Sequence 143830 from Patent EP1572962.
JD269753 - Sequence 250777 from Patent EP1572962.
JD230150 - Sequence 211174 from Patent EP1572962.
JD282028 - Sequence 263052 from Patent EP1572962.
JD561457 - Sequence 542481 from Patent EP1572962.
JD093100 - Sequence 74124 from Patent EP1572962.
JD184217 - Sequence 165241 from Patent EP1572962.
JD066831 - Sequence 47855 from Patent EP1572962.
JD176564 - Sequence 157588 from Patent EP1572962.
JD531878 - Sequence 512902 from Patent EP1572962.
JD187787 - Sequence 168811 from Patent EP1572962.
JD372381 - Sequence 353405 from Patent EP1572962.
JD472163 - Sequence 453187 from Patent EP1572962.
JD144584 - Sequence 125608 from Patent EP1572962.
JD395759 - Sequence 376783 from Patent EP1572962.
JD231898 - Sequence 212922 from Patent EP1572962.
JD144583 - Sequence 125607 from Patent EP1572962.
BC008600 - Homo sapiens chemokine (C-C motif) ligand 5, mRNA (cDNA clone MGC:17164 IMAGE:4185200), complete cds.
JD554728 - Sequence 535752 from Patent EP1572962.
JD323453 - Sequence 304477 from Patent EP1572962.
JD037118 - Sequence 18142 from Patent EP1572962.
JD521656 - Sequence 502680 from Patent EP1572962.
JD481645 - Sequence 462669 from Patent EP1572962.
JD390396 - Sequence 371420 from Patent EP1572962.
JD165424 - Sequence 146448 from Patent EP1572962.
JD146017 - Sequence 127041 from Patent EP1572962.
JD431904 - Sequence 412928 from Patent EP1572962.
JD358905 - Sequence 339929 from Patent EP1572962.
AF043341 - Homo sapiens RANTES precursor, mRNA, complete cds.
DQ891490 - Synthetic construct clone IMAGE:100004120; FLH177433.01X; RZPDo839A02126D chemokine (C-C motif) ligand 5 (CCL5) gene, encodes complete protein.
DQ894681 - Synthetic construct Homo sapiens clone IMAGE:100009141; FLH177429.01L; RZPDo839A02125D chemokine (C-C motif) ligand 5 (CCL5) gene, encodes complete protein.
AF266753 - Homo sapiens beta-chemokine RANTES precursor, mRNA, complete cds.
DQ230537 - Homo sapiens CCL5/RANTES variant (CCL5) mRNA, complete cds.
AK312212 - Homo sapiens cDNA, FLJ92501, highly similar to Homo sapiens chemokine (C-C motif) ligand 5 (CCL5), mRNA.
AB463488 - Synthetic construct DNA, clone: pF1KB6723, Homo sapiens CCL5 gene for chemokine (C-C motif) ligand 5, without stop codon, in Flexi system.
JD317550 - Sequence 298574 from Patent EP1572962.
JD555747 - Sequence 536771 from Patent EP1572962.
JD156087 - Sequence 137111 from Patent EP1572962.
MA444810 - JP 2018138019-A/16736: Polycomb-Associated Non-Coding RNAs.
MB143805 - JP 2019515670-A/16: METHODS FOR MONITORING AND TREATING CANCER.
MB423128 - JP 2019521641-A/15: METHODS FOR MONITORING AND TREATING CANCER.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_eosinophilsPathway - The Role of Eosinophils in the Chemokine Network of Allergy

Reactome (by CSHL, EBI, and GO)

Protein P13501 (Reactome details) participates in the following event(s):

R-HSA-373061 Receptors CCR3, 4 and 5 bind CCL5 ligand
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6783783 Interleukin-10 signaling
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-449147 Signaling by Interleukins
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: CCL5_HUMAN, D17S136E, ENST00000605140.1, ENST00000605140.2, ENST00000605140.3, ENST00000605140.4, ENST00000605140.5, NM_002985, O43646, P13501, Q0QVW8, Q4ZGJ1, Q9NYA2, Q9UBG2, Q9UC99, SCYA5, uc327iva.1, uc327iva.2
UCSC ID: ENST00000605140.6_7
RefSeq Accession: NM_002985.3
Protein: P13501 (aka CCL5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.