Human Gene CCNC (ENST00000520429.6_9) from GENCODE V47lift37
  Description: cyclin C, transcript variant 1 (from RefSeq NM_005190.4)
Gencode Transcript: ENST00000520429.6_9
Gencode Gene: ENSG00000112237.13_12
Transcript (Including UTRs)
   Position: hg19 chr6:99,990,263-100,016,536 Size: 26,274 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr6:99,991,431-100,016,403 Size: 24,973 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:99,990,263-100,016,536)mRNA (may differ from genome)Protein (283 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q7Z4L3_HUMAN
DESCRIPTION: SubName: Full=Cyclin C; SubName: Full=Cyclin C, isoform CRA_a;
SIMILARITY: Belongs to the cyclin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.02 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 390.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.80133-0.435 Picture PostScript Text
3' UTR -272.801168-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013763 - Cyclin-like
IPR023598 - Cyclin_C/H
IPR015429 - Cyclin_C/H/T/L
IPR006671 - Cyclin_N

Pfam Domains:
PF00134 - Cyclin, N-terminal domain

SCOP Domains:
47954 - Cyclin-like

ModBase Predicted Comparative 3D Structure on Q7Z4L3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity

Biological Process:
GO:0045859 regulation of protein kinase activity

Cellular Component:
GO:0016592 mediator complex


-  Descriptions from all associated GenBank mRNAs
  BC050726 - Homo sapiens cyclin C, mRNA (cDNA clone IMAGE:6165083), containing frame-shift errors.
AK222768 - Homo sapiens mRNA, CCNC protein variant, clone: HEP00488.
BC030159 - Homo sapiens cyclin C, mRNA (cDNA clone IMAGE:5022155), partial cds.
BC056153 - Homo sapiens cyclin C, mRNA (cDNA clone MGC:65052 IMAGE:6157106), complete cds.
BC010135 - Homo sapiens cyclin C, mRNA (cDNA clone MGC:19502 IMAGE:4106819), complete cds.
BC041123 - Homo sapiens cyclin C, mRNA (cDNA clone MGC:47670 IMAGE:5759974), complete cds.
AK223247 - Homo sapiens mRNA, CCNC protein variant, clone: STM05973.
AK291914 - Homo sapiens cDNA FLJ77471 complete cds, highly similar to Homo sapiens cyclin C (CCNC), transcript variant 1, mRNA.
M74091 - Human cyclin mRNA.
AK298558 - Homo sapiens cDNA FLJ52012 complete cds, highly similar to Cyclin-C.
AB125137 - Homo sapiens CCNC mRNA for cyclin C, complete cds.
CU691126 - Synthetic construct Homo sapiens gateway clone IMAGE:100021712 5' read CCNC mRNA.
HQ448076 - Synthetic construct Homo sapiens clone IMAGE:100071456; CCSB011984_02 cyclin C (CCNC) gene, encodes complete protein.
KJ890842 - Synthetic construct Homo sapiens clone ccsbBroadEn_00236 CCNC gene, encodes complete protein.
KJ896553 - Synthetic construct Homo sapiens clone ccsbBroadEn_05947 CCNC gene, encodes complete protein.
AB528579 - Synthetic construct DNA, clone: pF1KE0097, Homo sapiens CCNC gene for cyclin C, without stop codon, in Flexi system.
CU679631 - Synthetic construct Homo sapiens gateway clone IMAGE:100022392 5' read CCNC mRNA.
BC026272 - Homo sapiens cyclin C, mRNA (cDNA clone IMAGE:4250420), partial cds.
AK130983 - Homo sapiens cDNA FLJ27473 fis, clone DMC06528.
JD509130 - Sequence 490154 from Patent EP1572962.
JD439078 - Sequence 420102 from Patent EP1572962.
JD101608 - Sequence 82632 from Patent EP1572962.
JD034432 - Sequence 15456 from Patent EP1572962.
JD019534 - Sequence 558 from Patent EP1572962.
JD023807 - Sequence 4831 from Patent EP1572962.
JD025953 - Sequence 6977 from Patent EP1572962.
JD022448 - Sequence 3472 from Patent EP1572962.
JD032834 - Sequence 13858 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CCNC , ENST00000520429.1, ENST00000520429.2, ENST00000520429.3, ENST00000520429.4, ENST00000520429.5, hCG_1757197 , NM_005190, Q7Z4L3, Q7Z4L3_HUMAN, uc323tqs.1, uc323tqs.2
UCSC ID: ENST00000520429.6_9
RefSeq Accession: NM_005190.4
Protein: Q7Z4L3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.