Human Gene CCND2 (ENST00000261254.8_4) from GENCODE V47lift37
Description: cyclin D2 (from RefSeq NM_001759.4)Gencode Transcript: ENST00000261254.8_4Gencode Gene: ENSG00000118971.9_14Transcript (Including UTRs) Position: hg19 chr12:4,382,928-4,414,519 Size: 31,592 Total Exon Count: 5 Strand: +Coding Region Position: hg19 chr12:4,383,207-4,409,175 Size: 25,969 Coding Exon Count: 5
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: CCND2_HUMAN DESCRIPTION: RecName: Full=G1/S-specific cyclin-D2;FUNCTION: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).SUBUNIT: Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity.SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Membrane. Note=Cyclin D- CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members (By similarity).PTM: Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.SIMILARITY: Belongs to the cyclin family. Cyclin D subfamily.SIMILARITY: Contains 1 cyclin N-terminal domain.WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccnd2/";
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: CCND2
Diseases sorted by gene-association score: megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 * (1343), mpph syndrome * (247), megalencephaly (49), polymicrogyria (28), hydrocephalus (20), polydactyly (13), posterior uveal melanoma (13), mantle cell lymphoma (7), adult t-cell leukemia (7), breast cancer (5), embryonal carcinoma (5), burkitt lymphoma (4), b-cell lymphomas (4), medulloblastoma (3), chronic lymphocytic leukemia (2), colorectal cancer (2), retinal cancer (1), sensory system cancer (1), lymphoma, non-hodgkin (1)* = Manually curated disease association
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR013763 - Cyclin-likeIPR014400 - Cyclin_A/B/D/EIPR004367 - Cyclin_CIPR006671 - Cyclin_NPfam Domains: PF00134 - Cyclin, N-terminal domainPF02984 - Cyclin, C-terminal domainSCOP Domains: 47954 - Cyclin-likeModBase Predicted Comparative 3D Structure on P30279 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF213063 - JP 2014500723-A/20566: Polycomb-Associated Non-Coding RNAs.LF207409 - JP 2014500723-A/14912: Polycomb-Associated Non-Coding RNAs.LF212075 - JP 2014500723-A/19578: Polycomb-Associated Non-Coding RNAs.LF384197 - JP 2014500723-A/191700: Polycomb-Associated Non-Coding RNAs.LF213735 - JP 2014500723-A/21238: Polycomb-Associated Non-Coding RNAs.AK223577 - Homo sapiens mRNA for cyclin D2 variant, clone: FCC129F10.JD065155 - Sequence 46179 from Patent EP1572962.D13639 - Homo sapiens KIAK0002 mRNA, complete cds.JD443871 - Sequence 424895 from Patent EP1572962.BC089384 - Homo sapiens cyclin D2, mRNA (cDNA clone MGC:102758 IMAGE:6469822), complete cds.BC010958 - Homo sapiens cyclin D2, mRNA (cDNA clone MGC:13641 IMAGE:4133621), complete cds.AK291146 - Homo sapiens cDNA FLJ76185 complete cds, highly similar to Homo sapiens cyclin D2 (CCND2), mRNA.JD230763 - Sequence 211787 from Patent EP1572962.JD115436 - Sequence 96460 from Patent EP1572962.JD121167 - Sequence 102191 from Patent EP1572962.JD520068 - Sequence 501092 from Patent EP1572962.JD402776 - Sequence 383800 from Patent EP1572962.JD423550 - Sequence 404574 from Patent EP1572962.X68452 - H.sapiens mRNA for cyclin D2.JD413229 - Sequence 394253 from Patent EP1572962.JD126626 - Sequence 107650 from Patent EP1572962.JD170226 - Sequence 151250 from Patent EP1572962.JD476328 - Sequence 457352 from Patent EP1572962.M90813 - Human D-type cyclin (CCND2) mRNA, complete cds.AB385212 - Synthetic construct DNA, clone: pF1KB9409, Homo sapiens CCND2 gene for G1/S-specific cyclin-D2, complete cds, without stop codon, in Flexi system.KJ896554 - Synthetic construct Homo sapiens clone ccsbBroadEn_05948 CCND2 gene, encodes complete protein.DQ892845 - Synthetic construct clone IMAGE:100005475; FLH190230.01X; RZPDo839F1275D cyclin D2 (CCND2) gene, encodes complete protein.DQ896091 - Synthetic construct Homo sapiens clone IMAGE:100010551; FLH190226.01L; RZPDo839F1265D cyclin D2 (CCND2) gene, encodes complete protein.BT019847 - Homo sapiens cyclin D2 mRNA, complete cds.LF366032 - JP 2014500723-A/173535: Polycomb-Associated Non-Coding RNAs.AK097135 - Homo sapiens cDNA FLJ39816 fis, clone SPLEN2010119.LF366017 - JP 2014500723-A/173520: Polycomb-Associated Non-Coding RNAs.JD527274 - Sequence 508298 from Patent EP1572962.JD488252 - Sequence 469276 from Patent EP1572962.BX647508 - Homo sapiens mRNA; cDNA DKFZp686I03164 (from clone DKFZp686I03164).JD369079 - Sequence 350103 from Patent EP1572962.LF366016 - JP 2014500723-A/173519: Polycomb-Associated Non-Coding RNAs.JD355495 - Sequence 336519 from Patent EP1572962.JD263673 - Sequence 244697 from Patent EP1572962.JD304372 - Sequence 285396 from Patent EP1572962.JD342931 - Sequence 323955 from Patent EP1572962.LF366015 - JP 2014500723-A/173518: Polycomb-Associated Non-Coding RNAs.JD355135 - Sequence 336159 from Patent EP1572962.JD099997 - Sequence 81021 from Patent EP1572962.JD092712 - Sequence 73736 from Patent EP1572962.LF366014 - JP 2014500723-A/173517: Polycomb-Associated Non-Coding RNAs.JD141689 - Sequence 122713 from Patent EP1572962.JD041093 - Sequence 22117 from Patent EP1572962.JD530719 - Sequence 511743 from Patent EP1572962.JD313520 - Sequence 294544 from Patent EP1572962.JD556986 - Sequence 538010 from Patent EP1572962.JD360826 - Sequence 341850 from Patent EP1572962.JD430706 - Sequence 411730 from Patent EP1572962.JD531146 - Sequence 512170 from Patent EP1572962.JD326769 - Sequence 307793 from Patent EP1572962.LF366012 - JP 2014500723-A/173515: Polycomb-Associated Non-Coding RNAs.LF366011 - JP 2014500723-A/173514: Polycomb-Associated Non-Coding RNAs.LF366010 - JP 2014500723-A/173513: Polycomb-Associated Non-Coding RNAs.JD079871 - Sequence 60895 from Patent EP1572962.JD501218 - Sequence 482242 from Patent EP1572962.JD299050 - Sequence 280074 from Patent EP1572962.LF366009 - JP 2014500723-A/173512: Polycomb-Associated Non-Coding RNAs.JD102646 - Sequence 83670 from Patent EP1572962.JD108802 - Sequence 89826 from Patent EP1572962.JD228213 - Sequence 209237 from Patent EP1572962.JD108375 - Sequence 89399 from Patent EP1572962.LF366008 - JP 2014500723-A/173511: Polycomb-Associated Non-Coding RNAs.JD564914 - Sequence 545938 from Patent EP1572962.LF366007 - JP 2014500723-A/173510: Polycomb-Associated Non-Coding RNAs.JD377170 - Sequence 358194 from Patent EP1572962.JD468023 - Sequence 449047 from Patent EP1572962.DQ583121 - Homo sapiens piRNA piR-50233, complete sequence.JD268729 - Sequence 249753 from Patent EP1572962.JD554839 - Sequence 535863 from Patent EP1572962.JD437805 - Sequence 418829 from Patent EP1572962.JD186678 - Sequence 167702 from Patent EP1572962.JD409930 - Sequence 390954 from Patent EP1572962.JD231408 - Sequence 212432 from Patent EP1572962.JD200997 - Sequence 182021 from Patent EP1572962.JD067840 - Sequence 48864 from Patent EP1572962.JD315303 - Sequence 296327 from Patent EP1572962.LF366006 - JP 2014500723-A/173509: Polycomb-Associated Non-Coding RNAs.JD305855 - Sequence 286879 from Patent EP1572962.JD080340 - Sequence 61364 from Patent EP1572962.LF366005 - JP 2014500723-A/173508: Polycomb-Associated Non-Coding RNAs.JD171185 - Sequence 152209 from Patent EP1572962.JD312918 - Sequence 293942 from Patent EP1572962.JD501574 - Sequence 482598 from Patent EP1572962.JD202245 - Sequence 183269 from Patent EP1572962.JD165379 - Sequence 146403 from Patent EP1572962.JD139124 - Sequence 120148 from Patent EP1572962.JD174282 - Sequence 155306 from Patent EP1572962.JD245075 - Sequence 226099 from Patent EP1572962.JD285619 - Sequence 266643 from Patent EP1572962.JD375484 - Sequence 356508 from Patent EP1572962.JD518877 - Sequence 499901 from Patent EP1572962.JD221145 - Sequence 202169 from Patent EP1572962.JD469482 - Sequence 450506 from Patent EP1572962.JD255491 - Sequence 236515 from Patent EP1572962.JD400764 - Sequence 381788 from Patent EP1572962.JD214444 - Sequence 195468 from Patent EP1572962.JD529970 - Sequence 510994 from Patent EP1572962.JD152887 - Sequence 133911 from Patent EP1572962.JD060425 - Sequence 41449 from Patent EP1572962.JD180175 - Sequence 161199 from Patent EP1572962.JD172548 - Sequence 153572 from Patent EP1572962.JD452048 - Sequence 433072 from Patent EP1572962.JD315768 - Sequence 296792 from Patent EP1572962.BC014357 - Homo sapiens cyclin D2, mRNA (cDNA clone IMAGE:3686944), with apparent retained intron.JD473146 - Sequence 454170 from Patent EP1572962.JD201047 - Sequence 182071 from Patent EP1572962.LF366002 - JP 2014500723-A/173505: Polycomb-Associated Non-Coding RNAs.LF366001 - JP 2014500723-A/173504: Polycomb-Associated Non-Coding RNAs.JD203905 - Sequence 184929 from Patent EP1572962.LF366000 - JP 2014500723-A/173503: Polycomb-Associated Non-Coding RNAs.JD257943 - Sequence 238967 from Patent EP1572962.JD114151 - Sequence 95175 from Patent EP1572962.JD240582 - Sequence 221606 from Patent EP1572962.JD239333 - Sequence 220357 from Patent EP1572962.JD280406 - Sequence 261430 from Patent EP1572962.JD105434 - Sequence 86458 from Patent EP1572962.JD483583 - Sequence 464607 from Patent EP1572962.LF365999 - JP 2014500723-A/173502: Polycomb-Associated Non-Coding RNAs.JD114515 - Sequence 95539 from Patent EP1572962.JD253029 - Sequence 234053 from Patent EP1572962.JD252330 - Sequence 233354 from Patent EP1572962.JD349869 - Sequence 330893 from Patent EP1572962.JD251682 - Sequence 232706 from Patent EP1572962.JD283153 - Sequence 264177 from Patent EP1572962.JD167986 - Sequence 149010 from Patent EP1572962.JD377624 - Sequence 358648 from Patent EP1572962.LF365997 - JP 2014500723-A/173500: Polycomb-Associated Non-Coding RNAs.JD208103 - Sequence 189127 from Patent EP1572962.MA619774 - JP 2018138019-A/191700: Polycomb-Associated Non-Coding RNAs.MA601609 - JP 2018138019-A/173535: Polycomb-Associated Non-Coding RNAs.MA601594 - JP 2018138019-A/173520: Polycomb-Associated Non-Coding RNAs.MA601593 - JP 2018138019-A/173519: Polycomb-Associated Non-Coding RNAs.MA601592 - JP 2018138019-A/173518: Polycomb-Associated Non-Coding RNAs.MA601591 - JP 2018138019-A/173517: Polycomb-Associated Non-Coding RNAs.MA601589 - JP 2018138019-A/173515: Polycomb-Associated Non-Coding RNAs.MA601588 - JP 2018138019-A/173514: Polycomb-Associated Non-Coding RNAs.MA601587 - JP 2018138019-A/173513: Polycomb-Associated Non-Coding RNAs.MA601586 - JP 2018138019-A/173512: Polycomb-Associated Non-Coding RNAs.MA601585 - JP 2018138019-A/173511: Polycomb-Associated Non-Coding RNAs.MA601584 - JP 2018138019-A/173510: Polycomb-Associated Non-Coding RNAs.MA601583 - JP 2018138019-A/173509: Polycomb-Associated Non-Coding RNAs.MA601582 - JP 2018138019-A/173508: Polycomb-Associated Non-Coding RNAs.MA601579 - JP 2018138019-A/173505: Polycomb-Associated Non-Coding RNAs.MA601578 - JP 2018138019-A/173504: Polycomb-Associated Non-Coding RNAs.MA601577 - JP 2018138019-A/173503: Polycomb-Associated Non-Coding RNAs.MA601576 - JP 2018138019-A/173502: Polycomb-Associated Non-Coding RNAs.MA601574 - JP 2018138019-A/173500: Polycomb-Associated Non-Coding RNAs.MA448640 - JP 2018138019-A/20566: Polycomb-Associated Non-Coding RNAs.MA442986 - JP 2018138019-A/14912: Polycomb-Associated Non-Coding RNAs.MA447652 - JP 2018138019-A/19578: Polycomb-Associated Non-Coding RNAs.MA449312 - JP 2018138019-A/21238: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_cellcyclePathway - Cyclins and Cell Cycle RegulationReactome (by CSHL, EBI, and GO) Reactome details) participates in the following event(s):R-HSA-8941895 Formation of CDK4/6:CCND complexesR-HSA-8938867 CCND3,(CCND1,CCND2) binds RUNX1R-HSA-8941915 Cip/Kip CDK inhibitors bind CDK4/6:CCND complexesR-HSA-8942607 Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexesR-HSA-8942836 CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6R-HSA-69227 Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexesR-HSA-1226094 Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complexR-HSA-1226095 Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complexR-HSA-69231 Cyclin D associated events in G1R-HSA-8934593 Regulation of RUNX1 Expression and ActivityR-HSA-69236 G1 PhaseR-HSA-8878171 Transcriptional regulation by RUNX1R-HSA-453279 Mitotic G1-G1/S phasesR-HSA-212436 Generic Transcription PathwayR-HSA-69278 Cell Cycle (Mitotic)R-HSA-73857 RNA Polymerase II TranscriptionR-HSA-1640170 Cell CycleR-HSA-74160 Gene expression (Transcription)
Other Names for This Gene
Alternate Gene Symbols: A8K531, CCND2 , CCND2_HUMAN, ENST00000261254.1, ENST00000261254.2, ENST00000261254.3, ENST00000261254.4, ENST00000261254.5, ENST00000261254.6, ENST00000261254.7, NM_001759, P30279, Q13955, Q5U035, uc317gog.1, uc317gog.2UCSC ID: ENST00000261254.8_4RefSeq Accession: NM_001759.4 Protein: P30279
(aka CCND2_HUMAN)
GeneReviews for This Gene
GeneReviews article(s) related to gene CCND2:mpph
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
