ID:CCND3_HUMAN DESCRIPTION: RecName: Full=G1/S-specific cyclin-D3; FUNCTION: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. SUBUNIT: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A. INTERACTION: O94921:CDK14; NbExp=5; IntAct=EBI-375013, EBI-1043945; P11802:CDK4; NbExp=6; IntAct=EBI-375013, EBI-295644; Q00534:CDK6; NbExp=2; IntAct=EBI-375013, EBI-295663; P38936:CDKN1A; NbExp=3; IntAct=EBI-375013, EBI-375077; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Membrane. Note=Cyclin D- CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members (By similarity). PTM: Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation. SIMILARITY: Belongs to the cyclin family. Cyclin D subfamily. SIMILARITY: Contains 1 cyclin N-terminal domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccnd3/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P30281
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0005515 protein binding GO:0019901 protein kinase binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001934 positive regulation of protein phosphorylation GO:0007049 cell cycle GO:0007165 signal transduction GO:0042098 T cell proliferation GO:0042127 regulation of cell proliferation GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0046626 regulation of insulin receptor signaling pathway GO:0051301 cell division GO:0051726 regulation of cell cycle
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
