ID:CCNE2_HUMAN DESCRIPTION: RecName: Full=G1/S-specific cyclin-E2; FUNCTION: Essential for the control of the cell cycle at the late G1 and early S phase. SUBUNIT: Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. INTERACTION: P24941:CDK2; NbExp=5; IntAct=EBI-375033, EBI-375096; P38936:CDKN1A; NbExp=2; IntAct=EBI-375033, EBI-375077; P46527:CDKN1B; NbExp=2; IntAct=EBI-375033, EBI-519280; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor- derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon. INDUCTION: Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively. PTM: Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway (By similarity). SIMILARITY: Belongs to the cyclin family. Cyclin E subfamily. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccne2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O96020
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein O96020 (Reactome details) participates in the following event(s):
R-HSA-69191 Formation of Cyclin E:Cdk2 complexes R-HSA-69199 Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A R-HSA-69195 Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1 R-HSA-188386 Association of Rb with Cyclin E:Cdk2 complexes R-HSA-188350 CAK-mediated phosphorylation of Cyclin E:Cdk2 R-HSA-69562 Inactivation of Cyclin E:Cdk2 complexes by p27/p21 R-HSA-157906 Translocation of Cyclin E:Cdk2 complex to the nucleus R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) R-HSA-188390 Cyclin E:Cdk2-mediated phosphorylation of Rb R-HSA-1363303 p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 R-HSA-1363306 p130 (RBL2) binds Cyclin E/A:CDK2 R-HSA-1363311 p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 R-HSA-1363314 p107 (RBL1) binds CyclinE/A:CDK2 R-HSA-187520 Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 R-HSA-187552 Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex R-HSA-69005 Cdc6 protein is phosphorylated by CDK R-HSA-187575 Ubiquitination of phospho-p27/p21 R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69563 p53-Dependent G1 DNA Damage Response R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-69206 G1/S Transition R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint R-HSA-2559583 Cellular Senescence R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes R-HSA-1538133 G0 and Early G1 R-HSA-453279 Mitotic G1-G1/S phases R-HSA-390466 Chaperonin-mediated protein folding R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69615 G1/S DNA Damage Checkpoints R-HSA-2262752 Cellular responses to stress R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-69278 Cell Cycle (Mitotic) R-HSA-391251 Protein folding R-HSA-69242 S Phase R-HSA-69052 Switching of origins to a post-replicative state R-HSA-69620 Cell Cycle Checkpoints R-HSA-8953897 Cellular responses to external stimuli R-HSA-212436 Generic Transcription Pathway R-HSA-1640170 Cell Cycle R-HSA-392499 Metabolism of proteins R-HSA-69239 Synthesis of DNA R-HSA-73857 RNA Polymerase II Transcription R-HSA-69306 DNA Replication R-HSA-74160 Gene expression (Transcription)
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
