Human Gene CCNG1 (ENST00000340828.7_4) from GENCODE V47lift37
  Description: cyclin G1, transcript variant 15 (from RefSeq NR_157056.1)
Gencode Transcript: ENST00000340828.7_4
Gencode Gene: ENSG00000113328.21_13
Transcript (Including UTRs)
   Position: hg19 chr5:162,864,601-162,872,022 Size: 7,422 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr5:162,866,263-162,869,571 Size: 3,309 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:162,864,601-162,872,022)mRNA (may differ from genome)Protein (295 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CCNG1_HUMAN
DESCRIPTION: RecName: Full=Cyclin-G1; Short=Cyclin-G;
FUNCTION: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).
INTERACTION: Q15025:TNIP1; NbExp=3; IntAct=EBI-3905829, EBI-357849;
SUBCELLULAR LOCATION: Nucleus. Note=DNA replication foci after DNA damage.
TISSUE SPECIFICITY: High levels in skeletal muscle, ovary, kidney and colon.
DEVELOPMENTAL STAGE: Very low levels in normal cells during G1 phase, which increase as cells enter the S phase and stay high throughout the S and G2/M phases. In breast cancer cells consistent high levels are found throughout the cell cycle.
INDUCTION: Activated in breast and prostate cancer cells. Activated by actinomycin-D induced DNA damage.
SIMILARITY: Belongs to the cyclin family. Cyclin G subfamily.
SEQUENCE CAUTION: Sequence=AAB03903.1; Type=Erroneous initiation; Sequence=CAA54821.1; Type=Erroneous initiation;
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccng1/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCNG1
Diseases sorted by gene-association score: mantle cell lymphoma (4), breast cancer (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 85.36 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1386.01 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -108.70210-0.518 Picture PostScript Text
3' UTR -278.201346-0.207 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013763 - Cyclin-like
IPR006671 - Cyclin_N

Pfam Domains:
PF00134 - Cyclin, N-terminal domain

SCOP Domains:
47954 - Cyclin-like

ModBase Predicted Comparative 3D Structure on P51959
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007049 cell cycle
GO:0051301 cell division
GO:0051726 regulation of cell cycle

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm


-  Descriptions from all associated GenBank mRNAs
  AK316234 - Homo sapiens cDNA, FLJ79133 complete cds, highly similar to Cyclin-G1.
AK297190 - Homo sapiens cDNA FLJ51991 complete cds, highly similar to Cyclin-G1.
AK312913 - Homo sapiens cDNA, FLJ93362, Homo sapiens cyclin G1 (CCNG1), mRNA.
BC007093 - Homo sapiens cyclin G1, mRNA (cDNA clone MGC:14714 IMAGE:4251051), complete cds.
BX538035 - Homo sapiens mRNA; cDNA DKFZp686M0576 (from clone DKFZp686M0576).
D78341 - Homo sapiens mRNA for cyclin G, complete cds.
U47413 - Homo sapiens cyclin G1 mRNA, complete cds.
L49504 - Homo sapiens cyclin G1 mRNA, complete cds.
BC000196 - Homo sapiens cyclin G1, mRNA (cDNA clone MGC:643 IMAGE:3351902), complete cds.
JD068651 - Sequence 49675 from Patent EP1572962.
JD532903 - Sequence 513927 from Patent EP1572962.
U53328 - Human cyclin G mRNA, complete cds.
CU675541 - Synthetic construct Homo sapiens gateway clone IMAGE:100023318 5' read CCNG1 mRNA.
AB590348 - Synthetic construct DNA, clone: pFN21AE1507, Homo sapiens CCNG1 gene for cyclin G1, without stop codon, in Flexi system.
DQ893765 - Synthetic construct Homo sapiens clone IMAGE:100008225; FLH164326.01L; RZPDo839F02161D cyclin G1 (CCNG1) gene, encodes complete protein.
BT007134 - Homo sapiens cyclin G1 mRNA, complete cds.
EU176176 - Synthetic construct Homo sapiens clone IMAGE:100006331; FLH164333.01X; RZPDo839E02250D cyclin G1 (CCNG1) gene, encodes complete protein.
KJ890845 - Synthetic construct Homo sapiens clone ccsbBroadEn_00239 CCNG1 gene, encodes complete protein.
KJ896555 - Synthetic construct Homo sapiens clone ccsbBroadEn_05949 CCNG1 gene, encodes complete protein.
X77794 - H.sapiens mRNA for cyclin G1.
JD042031 - Sequence 23055 from Patent EP1572962.
JD553976 - Sequence 535000 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P51959 (Reactome details) participates in the following event(s):

R-HSA-6792871 CCNG1 recruits PP2A-PPP2R5C to MDM2
R-HSA-6792863 PP2A-PP2R5C dephosphorylates MDM2
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-6806003 Regulation of TP53 Expression and Degradation
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B2R7B2, B4DLW7, CCNG, CCNG1_HUMAN, CYCG1, D3DQK7, ENST00000340828.1, ENST00000340828.2, ENST00000340828.3, ENST00000340828.4, ENST00000340828.5, ENST00000340828.6, NR_157056, P51959, Q15757, Q96L32, uc317vup.1, uc317vup.2
UCSC ID: ENST00000340828.7_4
RefSeq Accession: NM_004060.4
Protein: P51959 (aka CCNG1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.