Human Gene CCNI (ENST00000237654.9_8) from GENCODE V47lift37
  Description: cyclin I, transcript variant 1 (from RefSeq NM_006835.3)
Gencode Transcript: ENST00000237654.9_8
Gencode Gene: ENSG00000118816.12_14
Transcript (Including UTRs)
   Position: hg19 chr4:77,968,308-77,997,142 Size: 28,835 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr4:77,969,372-77,987,515 Size: 18,144 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:77,968,308-77,997,142)mRNA (may differ from genome)Protein (377 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CCNI_HUMAN
DESCRIPTION: RecName: Full=Cyclin-I;
TISSUE SPECIFICITY: Highest levels in adult heart, brain and skeletal muscle. Lower levels in adult placenta, lung, kidney and pancreas. Also high levels in fetal brain and lower levels in fetal lung, liver and kidney. Also abundant in testis and thyroid.
DEVELOPMENTAL STAGE: Expression is independent of the cell cycle in lung fibroblasts.
SIMILARITY: Belongs to the cyclin family.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccni/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCNI
Diseases sorted by gene-association score: epilepsy, familial temporal lobe, 3 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 193.09 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 4800.66 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -233.60561-0.416 Picture PostScript Text
3' UTR -225.101064-0.212 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013763 - Cyclin-like
IPR006671 - Cyclin_N

Pfam Domains:
PF00134 - Cyclin, N-terminal domain

SCOP Domains:
47413 - lambda repressor-like DNA-binding domains
47954 - Cyclin-like

ModBase Predicted Comparative 3D Structure on Q14094
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0007283 spermatogenesis
GO:0051726 regulation of cell cycle


-  Descriptions from all associated GenBank mRNAs
  BC004975 - Homo sapiens cyclin I, mRNA (cDNA clone MGC:3795 IMAGE:2957878), complete cds.
LF383984 - JP 2014500723-A/191487: Polycomb-Associated Non-Coding RNAs.
AB209766 - Homo sapiens mRNA for CCNI protein variant protein.
BC000420 - Homo sapiens cyclin I, mRNA (cDNA clone MGC:8665 IMAGE:2964432), complete cds.
AK301111 - Homo sapiens cDNA FLJ50245 complete cds, highly similar to Cyclin-I.
AF135162 - Homo sapiens cyclin I (CYC1) mRNA, complete cds.
AK312632 - Homo sapiens cDNA, FLJ93016, Homo sapiens cyclin I (CCNI), mRNA.
MA619561 - JP 2018138019-A/191487: Polycomb-Associated Non-Coding RNAs.
LF206890 - JP 2014500723-A/14393: Polycomb-Associated Non-Coding RNAs.
LF359016 - JP 2014500723-A/166519: Polycomb-Associated Non-Coding RNAs.
LF359017 - JP 2014500723-A/166520: Polycomb-Associated Non-Coding RNAs.
AK222931 - Homo sapiens mRNA for cyclin I variant, clone: HRC09690.
D50310 - Homo sapiens mRNA for cyclin I, complete cds.
LF359018 - JP 2014500723-A/166521: Polycomb-Associated Non-Coding RNAs.
JD167359 - Sequence 148383 from Patent EP1572962.
BT020019 - Homo sapiens cyclin I mRNA, complete cds.
DQ891860 - Synthetic construct clone IMAGE:100004490; FLH180678.01X; RZPDo839E10134D cyclin I (CCNI) gene, encodes complete protein.
KJ893194 - Synthetic construct Homo sapiens clone ccsbBroadEn_02588 CCNI gene, encodes complete protein.
DQ895049 - Synthetic construct Homo sapiens clone IMAGE:100009509; FLH180674.01L; RZPDo839E10133D cyclin I (CCNI) gene, encodes complete protein.
CR541783 - Homo sapiens full open reading frame cDNA clone RZPDo834E0730D for gene CCNI, cyclin I; complete cds, without stopcodon.
DQ574163 - Homo sapiens piRNA piR-42275, complete sequence.
KY994047 - Homo sapiens QXBT5 miRNA, complete sequence.
KY994069 - Homo sapiens precursor microRNA QXBT5, complete sequence.
CU678836 - Synthetic construct Homo sapiens gateway clone IMAGE:100019147 5' read CCNI mRNA.
DL491704 - Novel nucleic acids.
DL490285 - Novel nucleic acids.
JD450238 - Sequence 431262 from Patent EP1572962.
MA442467 - JP 2018138019-A/14393: Polycomb-Associated Non-Coding RNAs.
MA594593 - JP 2018138019-A/166519: Polycomb-Associated Non-Coding RNAs.
MA594594 - JP 2018138019-A/166520: Polycomb-Associated Non-Coding RNAs.
MA594595 - JP 2018138019-A/166521: Polycomb-Associated Non-Coding RNAs.
JD260989 - Sequence 242013 from Patent EP1572962.
JD419396 - Sequence 400420 from Patent EP1572962.
JD368224 - Sequence 349248 from Patent EP1572962.
JD394765 - Sequence 375789 from Patent EP1572962.
JD129479 - Sequence 110503 from Patent EP1572962.
JD200872 - Sequence 181896 from Patent EP1572962.
JD389758 - Sequence 370782 from Patent EP1572962.
JD138621 - Sequence 119645 from Patent EP1572962.
JD218093 - Sequence 199117 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R6M0, B7Z6X4, CCNI , CCNI_HUMAN, ENST00000237654.1, ENST00000237654.2, ENST00000237654.3, ENST00000237654.4, ENST00000237654.5, ENST00000237654.6, ENST00000237654.7, ENST00000237654.8, NM_006835, Q14094, uc317ecx.1, uc317ecx.2
UCSC ID: ENST00000237654.9_8
RefSeq Accession: NM_006835.3
Protein: Q14094 (aka CCNI_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.