ID:CCNL2_HUMAN DESCRIPTION: RecName: Full=Cyclin-L2; AltName: Full=Paneth cell-enhanced expression protein; FUNCTION: Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Also modulates the expression of critical apoptotic factor, leading to cell apoptosis. SUBUNIT: Interacts with CDK11A, CDK11B, CDK12, CDK13, SFRS2, SFRS7 and POLR2A, the hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II. SUBCELLULAR LOCATION: Nucleus speckle. TISSUE SPECIFICITY: Ubiquitously expressed, with a higher expression level observed in ovary, heart, liver and pancreas. DOMAIN: Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity). SIMILARITY: Belongs to the cyclin family. Cyclin L subfamily. SEQUENCE CAUTION: Sequence=AAH71622.2; Type=Erroneous initiation; Sequence=BAB84938.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96S94
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
