Human Gene CCR3 (ENST00000395940.3_9) from GENCODE V47lift37
  Description: C-C motif chemokine receptor 3, transcript variant 2 (from RefSeq NM_178329.3)
Gencode Transcript: ENST00000395940.3_9
Gencode Gene: ENSG00000183625.16_14
Transcript (Including UTRs)
   Position: hg19 chr3:46,283,951-46,308,197 Size: 24,247 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr3:46,306,650-46,307,717 Size: 1,068 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:46,283,951-46,308,197)mRNA (may differ from genome)Protein (355 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CCR3_HUMAN
DESCRIPTION: RecName: Full=C-C chemokine receptor type 3; Short=C-C CKR-3; Short=CC-CKR-3; Short=CCR-3; Short=CCR3; Short=CKR3; AltName: Full=Eosinophil eotaxin receptor; AltName: CD_antigen=CD193;
FUNCTION: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
SUBUNIT: Binds to HIV-1 Tat.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: In eosinophils as well as trace amounts in neutrophils and monocytes.
MISCELLANEOUS: Overexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T-cell-mediated mucosal inflammation (PubMed:21077277).
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
WEB RESOURCE: Name=Wikipedia; Note=CC chemokine receptors entry; URL="http://en.wikipedia.org/wiki/CC_chemokine_receptors";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCR3
Diseases sorted by gene-association score: folliculotropic mycosis fungoides (18), aids dementia complex (12), hiv-1 (10), kaposi sarcoma (9), testicular leukemia (9), kimura disease (9), smooth muscle tumor (8), corneal ulcer (8), esophagitis (8), ileitis (7), orofacial granulomatosis (6), secondary progressive multiple sclerosis (6), allergic hypersensitivity disease (6), stevens-johnson syndrome/toxic epidermal necrolysis (5), mycosis fungoides (3), asthma (3), bronchial disease (1), macular degeneration, age-related, 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.26 RPKM in Whole Blood
Total median expression: 2.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.3090-0.226 Picture PostScript Text
3' UTR -87.60480-0.182 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR002238 - Chemokine_CCR3
IPR000355 - Chemokine_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on P51677
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0005515 protein binding
GO:0016493 C-C chemokine receptor activity
GO:0019957 C-C chemokine binding

Biological Process:
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006968 cellular defense response
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0016032 viral process
GO:0045766 positive regulation of angiogenesis
GO:0070098 chemokine-mediated signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK123050 - Homo sapiens cDNA FLJ41055 fis, clone SYNOV2000601, highly similar to C-C CHEMOKINE RECEPTOR TYPE 3.
BC033514 - Homo sapiens cDNA clone IMAGE:5176960, **** WARNING: chimeric clone ****.
AF262300 - Homo sapiens clone 2 CC chemokine receptor 3 (CCR3) mRNA, partial cds.
AF262299 - Homo sapiens clone 1 CC chemokine receptor 3 (CCR3) mRNA, partial cds.
AX513223 - Sequence 22 from Patent WO02062848.
AX513222 - Sequence 21 from Patent WO02062848.
AF224495 - Homo sapiens CC chemokine receptor 3 (CCR3) mRNA, partial cds.
AF262301 - Homo sapiens clone 4 CC chemokine receptor 3 (CCR3) mRNA, partial cds.
AF262302 - Homo sapiens clone 5 CC chemokine receptor 3 (CCR3) mRNA, partial cds.
AF262304 - Homo sapiens clone 7 CC chemokine receptor 3-like mRNA, partial sequence, alternatively spliced.
AF262303 - Homo sapiens clone 6 CC chemokine receptor 3 (CCR3) mRNA, partial cds.
BC130318 - Homo sapiens chemokine (C-C motif) receptor 3, mRNA (cDNA clone MGC:163190 IMAGE:40146349), complete cds.
BC130320 - Homo sapiens chemokine (C-C motif) receptor 3, mRNA (cDNA clone MGC:163192 IMAGE:40146351), complete cds.
AX513224 - Sequence 23 from Patent WO02062848.
BC110297 - Homo sapiens chemokine (C-C motif) receptor 3, mRNA (cDNA clone MGC:102841 IMAGE:5212541), complete cds.
AX513225 - Sequence 24 from Patent WO02062848.
U28694 - Human eosinophil CC chemokine receptor 3 mRNA, complete cds.
AB464481 - Synthetic construct DNA, clone: pF1KB8807, Homo sapiens CCR3 gene for chemokine (C-C motif) receptor 3, without stop codon, in Flexi system.
KJ890938 - Synthetic construct Homo sapiens clone ccsbBroadEn_00332 CCR3 gene, encodes complete protein.
AF026535 - Homo sapiens chemokine receptor (CCR3) mRNA, complete cds.
HQ258185 - Synthetic construct Homo sapiens clone IMAGE:100072494 chemokine (C-C motif) receptor 3 (CCR3), transcript variant 2 (CCR3) gene, encodes complete protein.
JD303145 - Sequence 284169 from Patent EP1572962.
JD092255 - Sequence 73279 from Patent EP1572962.
JD184708 - Sequence 165732 from Patent EP1572962.
JD316195 - Sequence 297219 from Patent EP1572962.
JD266963 - Sequence 247987 from Patent EP1572962.
JD501050 - Sequence 482074 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_nktPathway - Selective expression of chemokine receptors during T-cell polarization
h_CCR3Pathway - CCR3 signaling in Eosinophils
h_eosinophilsPathway - The Role of Eosinophils in the Chemokine Network of Allergy
h_il5Pathway - IL 5 Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein P51677 (Reactome details) participates in the following event(s):

R-HSA-373061 Receptors CCR3, 4 and 5 bind CCL5 ligand
R-HSA-8862733 CCR2, CCR3 bind CCL13
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B3KVQ1, CCR3_HUMAN, CMKBR3, ENST00000395940.1, ENST00000395940.2, F5GWL6, NM_178329, P51677, Q15748, Q2YDB9, Q86WD2, Q8TDP6, Q9ULY8, uc318xvz.1, uc318xvz.2
UCSC ID: ENST00000395940.3_9
RefSeq Accession: NM_178329.3
Protein: P51677 (aka CCR3_HUMAN or CKR3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.