Human Gene CCR8 (ENST00000326306.5_4) from GENCODE V47lift37
  Description: C-C motif chemokine receptor 8 (from RefSeq NM_005201.4)
Gencode Transcript: ENST00000326306.5_4
Gencode Gene: ENSG00000179934.7_7
Transcript (Including UTRs)
   Position: hg19 chr3:39,371,200-39,375,171 Size: 3,972 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr3:39,373,823-39,374,890 Size: 1,068 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:39,371,200-39,375,171)mRNA (may differ from genome)Protein (355 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CCR8_HUMAN
DESCRIPTION: RecName: Full=C-C chemokine receptor type 8; Short=C-C CKR-8; Short=CC-CKR-8; Short=CCR-8; AltName: Full=CC chemokine receptor CHEMR1; AltName: Full=CMKBRL2; AltName: Full=Chemokine receptor-like 1; Short=CKR-L1; AltName: Full=GPR-CY6; Short=GPRCY6; AltName: Full=TER1; AltName: CD_antigen=CDw198;
FUNCTION: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CAUTION: Was originally (PubMed:9521068) thought to be a receptor for SCYA3 and SCYA17.
WEB RESOURCE: Name=Wikipedia; Note=CC chemokine receptors entry; URL="http://en.wikipedia.org/wiki/CC_chemokine_receptors";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCR8
Diseases sorted by gene-association score: molluscum contagiosum (9), kaposi sarcoma (7), igg4-related sclerosing cholangitis (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.06 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -41.90135-0.310 Picture PostScript Text
3' UTR -59.00281-0.210 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR004068 - Chemokine_CCR8
IPR000355 - Chemokine_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on P51685
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0015026 coreceptor activity
GO:0016493 C-C chemokine receptor activity

Biological Process:
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0070098 chemokine-mediated signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK314957 - Homo sapiens cDNA, FLJ95872, Homo sapiens chemokine (C-C motif) receptor 8 (CCR8), mRNA.
AF005210 - Homo sapiens CC chemokine receptor CCR8 (CMKBR8) mRNA, partial cds.
JD382444 - Sequence 363468 from Patent EP1572962.
JD199904 - Sequence 180928 from Patent EP1572962.
BC107159 - Homo sapiens chemokine (C-C motif) receptor 8, mRNA (cDNA clone MGC:129973 IMAGE:40032938), complete cds.
D49919 - Homo sapiens mRNA for C-C chemokine receptor type 2, complete cds.
BC107152 - Homo sapiens chemokine (C-C motif) receptor 8, mRNA (cDNA clone MGC:129966 IMAGE:40032486), complete cds.
LF208668 - JP 2014500723-A/16171: Polycomb-Associated Non-Coding RNAs.
JD062575 - Sequence 43599 from Patent EP1572962.
JD094701 - Sequence 75725 from Patent EP1572962.
BC074743 - Homo sapiens chemokine (C-C motif) receptor 8, mRNA (cDNA clone MGC:103820 IMAGE:30915201), complete cds.
BC069067 - Homo sapiens chemokine (C-C motif) receptor 8, mRNA (cDNA clone MGC:95341 IMAGE:7216880), complete cds.
AB464484 - Synthetic construct DNA, clone: pF1KB8808, Homo sapiens CCR8 gene for chemokine (C-C motif) receptor 8, without stop codon, in Flexi system.
KJ904440 - Synthetic construct Homo sapiens clone ccsbBroadEn_13834 CCR8-like gene, encodes complete protein.
JD349566 - Sequence 330590 from Patent EP1572962.
MA444245 - JP 2018138019-A/16171: Polycomb-Associated Non-Coding RNAs.
MB021217 - JP 2019050736-A/1: Diagnostic biomarker for vasculitis.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P51685 (Reactome details) participates in the following event(s):

R-HSA-8851352 CCR8 binds CCL1
R-HSA-373073 Receptors CCR1, 2 and 8 bind CCL16 ligand
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2RC64, CCR8_HUMAN, CKRL1, CMKBR8, CMKBRL2, ENST00000326306.1, ENST00000326306.2, ENST00000326306.3, ENST00000326306.4, NM_005201, P51685, Q3KNQ8, Q3KNR3, Q9BYX5, uc317saq.1, uc317saq.2
UCSC ID: ENST00000326306.5_4
RefSeq Accession: NM_005201.4
Protein: P51685 (aka CCR8_HUMAN or CKR8_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.