Human Gene CCT2 (ENST00000299300.11_4) from GENCODE V47lift37
  Description: chaperonin containing TCP1 subunit 2, transcript variant 1 (from RefSeq NM_006431.3)
Gencode Transcript: ENST00000299300.11_4
Gencode Gene: ENSG00000166226.13_7
Transcript (Including UTRs)
   Position: hg19 chr12:69,979,239-69,995,350 Size: 16,112 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg19 chr12:69,979,302-69,995,105 Size: 15,804 Coding Exon Count: 16 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:69,979,239-69,995,350)mRNA (may differ from genome)Protein (535 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCT2
Diseases sorted by gene-association score: gallbladder adenocarcinoma (13), adenosquamous carcinoma (7), giant axonal neuropathy (5), bardet-biedl syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D006861 Hydrogen Peroxide
  • D004997 Ethinyl Estradiol
  • D013749 Tetrachlorodibenzodioxin
  • D014635 Valproic Acid
  • C016403 2,4-dinitrotoluene
  • C023514 2,6-dinitrotoluene
  • C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
  • C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
  • C035207 4-amino-2,6-dinitrotoluene
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 163.74 RPKM in Testis
Total median expression: 1947.26 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.4063-0.340 Picture PostScript Text
3' UTR -45.10245-0.184 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Descriptions from all associated GenBank mRNAs
  AK290767 - Homo sapiens cDNA FLJ75037 complete cds, highly similar to Homo sapiens chaperonin containing TCP1, subunit 2 (beta) (CCT2),mRNA.
BC113514 - Homo sapiens chaperonin containing TCP1, subunit 2 (beta), mRNA (cDNA clone MGC:142074 IMAGE:8322566), complete cds.
BC113516 - Homo sapiens chaperonin containing TCP1, subunit 2 (beta), mRNA (cDNA clone MGC:142076 IMAGE:8322568), complete cds.
AK297685 - Homo sapiens cDNA FLJ50585 complete cds, highly similar to T-complex protein 1 subunit beta.
AF026166 - Homo sapiens chaperonin-containing TCP-1 beta subunit homolog mRNA, complete cds.
AF026293 - Homo sapiens chaperonin containing t-complex polypeptide 1, beta subunit (Cctb) mRNA, complete cds.
FJ224351 - Homo sapiens epididymis secretory sperm binding protein Li 100n (HEL-S-100n) mRNA, complete cds.
AK294307 - Homo sapiens cDNA FLJ50480 complete cds, highly similar to T-complex protein 1 subunit beta.
AK316408 - Homo sapiens cDNA, FLJ79307 complete cds, highly similar to T-complex protein 1 subunit beta.
AK316397 - Homo sapiens cDNA, FLJ79296 complete cds, highly similar to T-complex protein 1 subunit beta.
AK302157 - Homo sapiens cDNA FLJ52359 complete cds, highly similar to T-complex protein 1 subunit beta.
AB385008 - Synthetic construct DNA, clone: pF1KB4985, Homo sapiens CCT2 gene for T-complex protein 1 subunit beta, complete cds, without stop codon, in Flexi system.
AB451346 - Homo sapiens CCT2 mRNA for T-complex protein 1 subunit beta, partial cds, clone: FLJ08008AAAF.
HQ258283 - Synthetic construct Homo sapiens clone IMAGE:100072592 chaperonin containing TCP1, subunit 2 (beta) (CCT2) gene, encodes complete protein.
KJ898248 - Synthetic construct Homo sapiens clone ccsbBroadEn_07642 CCT2 gene, encodes complete protein.
KJ906049 - Synthetic construct Homo sapiens clone ccsbBroadEn_15719 CCT2 gene, encodes complete protein.
BT019966 - Homo sapiens chaperonin containing TCP1, subunit 2 (beta) mRNA, complete cds.
AB451223 - Homo sapiens CCT2 mRNA for T-complex protein 1 subunit beta, complete cds, clone: FLJ08008AAAN.
CR457071 - Homo sapiens full open reading frame cDNA clone RZPDo834F0614D for gene CCT2, chaperonin containing TCP1, subunit 2 (beta); complete cds, incl. stopcodon.
JD553008 - Sequence 534032 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CCT2 , ENST00000299300.1, ENST00000299300.10, ENST00000299300.2, ENST00000299300.3, ENST00000299300.4, ENST00000299300.5, ENST00000299300.6, ENST00000299300.7, ENST00000299300.8, ENST00000299300.9, hCG_24460 , HEL-S-100n , NM_006431, uc317miv.1, uc317miv.2, V9HW96, V9HW96_HUMAN
UCSC ID: ENST00000299300.11_4
RefSeq Accession: NM_006431.3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.