ID:TCPH_HUMAN DESCRIPTION: RecName: Full=T-complex protein 1 subunit eta; Short=TCP-1-eta; AltName: Full=CCT-eta; AltName: Full=HIV-1 Nef-interacting protein; FUNCTION: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). SUBUNIT: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. SUBCELLULAR LOCATION: Cytoplasm (By similarity). SIMILARITY: Belongs to the TCP-1 chaperonin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99832
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006457 protein folding GO:0006458 'de novo' protein folding GO:0007339 binding of sperm to zona pellucida GO:0032212 positive regulation of telomere maintenance via telomerase GO:0050821 protein stabilization GO:0061077 chaperone-mediated protein folding GO:1901998 toxin transport GO:1904851 positive regulation of establishment of protein localization to telomere GO:1904871 positive regulation of protein localization to Cajal body GO:1904874 positive regulation of telomerase RNA localization to Cajal body
BC088351 - Homo sapiens chaperonin containing TCP1, subunit 7 (eta), mRNA (cDNA clone MGC:110985 IMAGE:6202511), complete cds. AK291961 - Homo sapiens cDNA FLJ77695 complete cds, highly similar to Homo sapiens chaperonin containing TCP1, subunit 7 (eta) (CCT7),mRNA. AK293597 - Homo sapiens cDNA FLJ54832 complete cds, highly similar to T-complex protein 1 subunit eta. AK297846 - Homo sapiens cDNA FLJ54074 complete cds, highly similar to T-complex protein 1 subunit eta. AK298153 - Homo sapiens cDNA FLJ59364 complete cds, highly similar to T-complex protein 1 subunit eta. AK302078 - Homo sapiens cDNA FLJ54568 complete cds, highly similar to T-complex protein 1 subunit eta. AK098549 - Homo sapiens cDNA FLJ25683 fis, clone TST04180, highly similar to T-COMPLEX PROTEIN 1, ETA SUBUNIT. AK293175 - Homo sapiens cDNA FLJ59454 complete cds, highly similar to T-complex protein 1 subunit eta. AF026292 - Homo sapiens chaperonin containing t-complex polypeptide 1, eta subunit (Ccth) mRNA, complete cds. BC019296 - Homo sapiens chaperonin containing TCP1, subunit 7 (eta), mRNA (cDNA clone MGC:4110 IMAGE:2905446), complete cds. JD192140 - Sequence 173164 from Patent EP1572962. AK222478 - Homo sapiens mRNA for chaperonin containing TCP1, subunit 7 (eta) variant, clone: adKA03022. JD066587 - Sequence 47611 from Patent EP1572962. CU676420 - Synthetic construct Homo sapiens gateway clone IMAGE:100023479 5' read CCT7 mRNA. CR456719 - Homo sapiens full open reading frame cDNA clone RZPDo834H033D for gene CCT7, chaperonin containing TCP1, subunit 7 (eta); complete cds, incl. stopcodon. AB385063 - Synthetic construct DNA, clone: pF1KB5205, Homo sapiens CCT7 gene for T-complex protein 1 subunit eta, complete cds, without stop codon, in Flexi system. DQ893464 - Synthetic construct clone IMAGE:100006094; FLH193374.01X; RZPDo839F0778D chaperonin containing TCP1, subunit 7 (eta) (CCT7) gene, encodes complete protein. DQ896334 - Synthetic construct Homo sapiens clone IMAGE:100010794; FLH193370.01L; RZPDo839F0768D chaperonin containing TCP1, subunit 7 (eta) (CCT7) gene, encodes complete protein. CR536511 - Homo sapiens full open reading frame cDNA clone RZPDo834H1221D for gene CCT7, chaperonin containing TCP1, subunit 7 (eta); complete cds, incl. stopcodon. KJ898247 - Synthetic construct Homo sapiens clone ccsbBroadEn_07641 CCT7 gene, encodes complete protein. U83843 - Human HIV-1 Nef interacting protein (Nip7-1) mRNA, partial cds. DQ586779 - Homo sapiens piRNA piR-53891, complete sequence. AK098825 - Homo sapiens cDNA FLJ25959 fis, clone TST06756, highly similar to T-COMPLEX PROTEIN 1, ETA SUBUNIT. JD363830 - Sequence 344854 from Patent EP1572962. JD543815 - Sequence 524839 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q99832 (Reactome details) participates in the following event(s):
R-HSA-389954 Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC R-HSA-389961 ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex R-HSA-389970 Actin/tubulin:prefoldin complex associates with CCT/TriC R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) R-HSA-391266 Association of CCT/TriC with sphingosine kinase 1 R-HSA-6814119 TRiC/CCT binds unfolded G-protein beta subunit R-HSA-390453 Hydrolysis of ATP and release of folded actin from CCT/TriC R-HSA-8850527 PDCL releases folded G-beta from TRiC/CCT R-HSA-8850539 Release of GNB5:RGS dimers from CCT/TRiC R-HSA-390459 Exchange of ADP for ATP in CCT/TriC:actin complex R-HSA-6814124 ATP binds G-protein beta associated TRiC/CCT R-HSA-8850529 RGS proteins bind GNB5 and CCT/TRiC R-HSA-8850534 PDCL promotes G-protein beta 5 folding R-HSA-6814121 PDCL binds G-protein beta and TRiC/CCT R-HSA-6814120 ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-390450 Folding of actin by CCT/TriC R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-390466 Chaperonin-mediated protein folding R-HSA-391251 Protein folding R-HSA-392499 Metabolism of proteins
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
