ID:CD14_HUMAN DESCRIPTION: RecName: Full=Monocyte differentiation antigen CD14; AltName: Full=Myeloid cell-specific leucine-rich glycoprotein; AltName: CD_antigen=CD14; Contains: RecName: Full=Monocyte differentiation antigen CD14, urinary form; Contains: RecName: Full=Monocyte differentiation antigen CD14, membrane-bound form; Flags: Precursor; FUNCTION: Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. SUBUNIT: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. TISSUE SPECIFICITY: Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages. PTM: N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. SIMILARITY: Contains 11 LRR (leucine-rich) repeats. WEB RESOURCE: Name=Wikipedia; Note=CD14 entry; URL="http://en.wikipedia.org/wiki/CD14";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 52047 - RNI-like 52058 - L domain-like 52075 - Outer arm dynein light chain 1
ModBase Predicted Comparative 3D Structure on P08571
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF211017 - JP 2014500723-A/18520: Polycomb-Associated Non-Coding RNAs. LF212731 - JP 2014500723-A/20234: Polycomb-Associated Non-Coding RNAs. LF213421 - JP 2014500723-A/20924: Polycomb-Associated Non-Coding RNAs. AX429254 - Sequence 9 from Patent WO0235236. M86511 - Human monocyte antigen CD14 (CD14) mRNA, complete cds. BC010507 - Homo sapiens CD14 molecule, mRNA (cDNA clone MGC:17221 IMAGE:4149008), complete cds. X13334 - Human CD14 mRNA for myelid cell-specific leucine-rich glycoprotein. HV447129 - WO 1998039438-A/1: Antisense compound against CD14. JD171944 - Sequence 152968 from Patent EP1572962. JD087741 - Sequence 68765 from Patent EP1572962. AF097942 - Homo sapiens monocyte antigen CD14 precursor (CD14) mRNA, complete cds. AB446505 - Homo sapiens CD14 mRNA for monocyte differentiation antigen CD14, complete cds. AK313277 - Homo sapiens cDNA, FLJ93789, highly similar to Homo sapiens CD14 antigen (CD14), mRNA. BT007331 - Homo sapiens CD14 antigen mRNA, complete cds. KJ890855 - Synthetic construct Homo sapiens clone ccsbBroadEn_00249 CD14 gene, encodes complete protein. AM392692 - Synthetic construct Homo sapiens clone IMAGE:100002988 for hypothetical protein (CD14 gene). AM392824 - Synthetic construct Homo sapiens clone IMAGE:100002989 for hypothetical protein (CD14 gene). AM393386 - Synthetic construct Homo sapiens clone IMAGE:100002738 for hypothetical protein (CD14 gene). AM393697 - Synthetic construct Homo sapiens clone IMAGE:100002739 for hypothetical protein (CD14 gene). AB528100 - Synthetic construct DNA, clone: pF1KE0478, Homo sapiens CD14 gene for CD14 molecule, without stop codon, in Flexi system. CQ873860 - Sequence 279 from Patent WO2004076622. DD413697 - Regulation of Mammalian Cells. AY044269 - Homo sapiens CD14 antigen mRNA, partial cds. LF343259 - JP 2014500723-A/150762: Polycomb-Associated Non-Coding RNAs. MA578836 - JP 2018138019-A/150762: Polycomb-Associated Non-Coding RNAs. MA446594 - JP 2018138019-A/18520: Polycomb-Associated Non-Coding RNAs. MA448308 - JP 2018138019-A/20234: Polycomb-Associated Non-Coding RNAs. MA448998 - JP 2018138019-A/20924: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P08571 (Reactome details) participates in the following event(s):
R-HSA-169719 Secreted CD14 binds LPS R-HSA-8869694 oxPL binds CD14 R-HSA-166038 GPI-bound CD14 binds LPS R-HSA-2559464 TLR6/2 ligand associates with CD14 and CD36 within lipid rafts R-HSA-2559468 TLR1/2 ligand binds to CD14 R-HSA-168950 TLR6:TLR2 is recruited to ligand:CD14:CD36 R-HSA-168951 TLR1:TLR2 is recruited to ligand:CD14 R-HSA-6798743 Exocytosis of secretory granule membrane proteins R-HSA-166168 TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) R-HSA-2201293 Endocytosis of TLR4:LY96:LPS:CD14 R-HSA-166041 Transfer of LPS onto TLR4 R-HSA-2559439 CD14:LPS binds CR3 R-HSA-166175 TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) R-HSA-2201316 Activated TLR2/4 interacts with MAL(TIRAP) R-HSA-168921 TRIF:activated TLR3/TLR4 complex recruits RIP1 R-HSA-936985 Activated TLR4:TICAM1 recruits TRAF6 R-HSA-2201338 TRAF3 binds TICAM1:activated TLR4 complex R-HSA-2559568 SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 R-HSA-937075 Phosphorylated TAK1 leaves activated TLR receptor complex R-HSA-166072 MyD88 forms a complex with MAL:activated TLR2/4 R-HSA-2201322 MAL is phosphorylated by BTK R-HSA-2559414 Activated TLR2/4:MAL interacts with BTK R-HSA-168915 K63-linked ubiquitination of RIP1 bound to the activated TLR complex R-HSA-2562541 TLR4-induced ripoptosome assembly R-HSA-936947 Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex R-HSA-937029 IKBKG subunit of IKK complex binds polyubiquinated RIP1 R-HSA-5362486 TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 R-HSA-2562564 Caspase-8 processing within TLR4 complex R-HSA-2569057 RIP3 binds TRIF to mediate necroptosis R-HSA-937079 MyD88 oligomerization within the complex of activated TLR:Mal:MyD88 R-HSA-166082 IRAK4 binds to the activated TLR receptor:Mal:MyD88 complex R-HSA-936951 Activation of TAK1 complex bound to activated TLR4 complex R-HSA-936941 Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation R-HSA-937022 IRAK4 autophosphorylation in the complex with activated TLR:MyD88:Mal R-HSA-166091 IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:Mal complex R-HSA-166362 Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex R-HSA-2262775 Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex R-HSA-166271 IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 R-HSA-166245 Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex R-HSA-166286 Multiple IRAK1 autophosphorylation steps R-HSA-166284 Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal R-HSA-166119 First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal R-HSA-166363 TRAF6 binds to hp- IRAK1 R-HSA-937059 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:Mal:activated TLR complex R-HSA-2262777 TRAF6 binds to p-IRAK2 R-HSA-166020 Transfer of LPS from LBP carrier to CD14 R-HSA-5686938 Regulation of TLR by endogenous ligand R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-168898 Toll-Like Receptors Cascades R-HSA-6798695 Neutrophil degranulation R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-168249 Innate Immune System R-HSA-166166 MyD88-independent TLR4 cascade R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-168256 Immune System R-HSA-937041 IKK complex recruitment mediated by RIP1 R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-5602498 MyD88 deficiency (TLR2/4) R-HSA-2562578 TRIF-mediated programmed cell death R-HSA-140534 Ligand-dependent caspase activation R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling R-HSA-5603041 IRAK4 deficiency (TLR2/4) R-HSA-5602358 Diseases associated with the TLR signaling cascade R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5260271 Diseases of Immune System R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-109581 Apoptosis R-HSA-1643685 Disease R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-5357801 Programmed Cell Death R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
