Human Gene CD27 (ENST00000266557.4_4) from GENCODE V47lift37
  Description: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1. (from UniProt P26842)
Gencode Transcript: ENST00000266557.4_4
Gencode Gene: ENSG00000139193.4_6
Transcript (Including UTRs)
   Position: hg19 chr12:6,554,121-6,560,879 Size: 6,759 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr12:6,554,262-6,560,558 Size: 6,297 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:6,554,121-6,560,879)mRNA (may differ from genome)Protein (260 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MalacardsMGIPubMedReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: CD27_HUMAN
DESCRIPTION: RecName: Full=CD27 antigen; AltName: Full=CD27L receptor; AltName: Full=T-cell activation antigen CD27; AltName: Full=T14; AltName: Full=Tumor necrosis factor receptor superfamily member 7; AltName: CD_antigen=CD27; Flags: Precursor;
FUNCTION: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
SUBUNIT: Homodimer. Interacts with SIVA1 and TRAF2.
INTERACTION: O15304:SIVA1; NbExp=3; IntAct=EBI-520729, EBI-520756;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Found in most T-lymphocytes.
PTM: Phosphorylated.
PTM: O-glycosylated with core 1 or possibly core 8 glycans.
SIMILARITY: Contains 3 TNFR-Cys repeats.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/tnfrsf7/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CD27
Diseases sorted by gene-association score: lymphoproliferative syndrome 2* (1336), autosomal recessive lymphoproliferative disease* (247), lymphoproliferative syndrome (18), precursor b lymphoblastic lymphoma/leukemia (11), pars planitis (11), macroglobulinemia (9), chronic lymphocytic leukemia (9), precursor lymphoblastic lymphoma/leukemia (9), follicular lymphoma (8), common variable immunodeficiency (7), cryoglobulinemia (7), cloacogenic carcinoma (7), monoclonal paraproteinemia (7), solitary osseous plasmacytoma (6), tetanus (6), transverse myelitis (6), b cell deficiency (5), hemophagocytic lymphohistiocytosis (3), lymphoma, non-hodgkin (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 83.32 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 232.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.10141-0.405 Picture PostScript Text
3' UTR -112.50321-0.350 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001368 - TNFR/NGFR_Cys_rich_reg
IPR022328 - TNFR_7

Pfam Domains:
PF00020 - TNFR/NGFR cysteine-rich region

SCOP Domains:
57586 - TNF receptor-like
57184 - Growth factor receptor domain

ModBase Predicted Comparative 3D Structure on P26842
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004888 transmembrane signaling receptor activity
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005515 protein binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process:
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007275 multicellular organism development
GO:0016064 immunoglobulin mediated immune response
GO:0032496 response to lipopolysaccharide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042127 regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045471 response to ethanol
GO:0045579 positive regulation of B cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0046330 positive regulation of JNK cascade
GO:0070233 negative regulation of T cell apoptotic process
GO:0097191 extrinsic apoptotic signaling pathway
GO:1901224 positive regulation of NIK/NF-kappaB signaling

Cellular Component:
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF207398 - JP 2014500723-A/14901: Polycomb-Associated Non-Coding RNAs.
MA442975 - JP 2018138019-A/14901: Polycomb-Associated Non-Coding RNAs.
AK315732 - Homo sapiens cDNA, FLJ96839, highly similar to Homo sapiens tumor necrosis factor receptor superfamily, member 7 (TNFRSF7), mRNA.
LP895836 - Sequence 700 from Patent EP3253886.
BC012160 - Homo sapiens CD27 molecule, mRNA (cDNA clone MGC:20393 IMAGE:4575359), complete cds.
JD213841 - Sequence 194865 from Patent EP1572962.
JD189539 - Sequence 170563 from Patent EP1572962.
JD530251 - Sequence 511275 from Patent EP1572962.
JD077575 - Sequence 58599 from Patent EP1572962.
LQ882882 - Sequence 31 from Patent WO2018160841.
M63928 - Homo sapiens T cell activation antigen (CD27) mRNA, complete cds.
JD370799 - Sequence 351823 from Patent EP1572962.
DQ892296 - Synthetic construct clone IMAGE:100004926; FLH184982.01X; RZPDo839D12146D tumor necrosis factor receptor superfamily, member 7 (TNFRSF7) gene, encodes complete protein.
EU176659 - Synthetic construct Homo sapiens clone IMAGE:100011483; FLH184981.01L; RZPDo839H02255D CD27 molecule (CD27) gene, encodes complete protein.
AB590221 - Synthetic construct DNA, clone: pFN21AE1571, Homo sapiens CD27 gene for CD27 molecule, without stop codon, in Flexi system.
CU680244 - Synthetic construct Homo sapiens gateway clone IMAGE:100018643 5' read CD27 mRNA.
KJ890859 - Synthetic construct Homo sapiens clone ccsbBroadEn_00253 CD27 gene, encodes complete protein.
JD443707 - Sequence 424731 from Patent EP1572962.
JD393174 - Sequence 374198 from Patent EP1572962.
JD199901 - Sequence 180925 from Patent EP1572962.
JD114626 - Sequence 95650 from Patent EP1572962.
JD275214 - Sequence 256238 from Patent EP1572962.
JD056762 - Sequence 37786 from Patent EP1572962.
JD350185 - Sequence 331209 from Patent EP1572962.
JD343872 - Sequence 324896 from Patent EP1572962.
JD373026 - Sequence 354050 from Patent EP1572962.
JD303364 - Sequence 284388 from Patent EP1572962.
LQ927244 - Sequence 21 from Patent WO2018191660.
MP584532 - Sequence 31 from Patent WO2020081767.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P26842 (Reactome details) participates in the following event(s):

R-HSA-5669024 CD70 binds CD27
R-HSA-5669034 TNFs bind their physiological receptors
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: B2RDZ0, CD27_HUMAN, ENST00000266557.1, ENST00000266557.2, ENST00000266557.3, NR_182128, P26842, TNFRSF7, uc317iho.1, uc317iho.2
UCSC ID: ENST00000266557.4_4
RefSeq Accession: NM_001242.5
Protein: P26842 (aka CD27_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.