ID:CD2AP_HUMAN DESCRIPTION: RecName: Full=CD2-associated protein; AltName: Full=Adapter protein CMS; AltName: Full=Cas ligand with multiple SH3 domains; FUNCTION: Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. SUBUNIT: Self-associates. Homodimer (Potential). Interacts (via SH3 2 domain) with CBL (via phosphorylated C-terminus). Interacts with BCAR1/p130Cas (via SH3 domain). Interacts with F-actin, PKD2, NPHS1 and NPHS2. Interacts with WTIP (By similarity). Interacts with FAM125A and ARHGAP17. Interacts with ANLN, CD2 and CBLB. Interacts with PDCD6IP and TSG101. Interacts with DDN; interaction is direct (By similarity). INTERACTION: P62993:GRB2; NbExp=3; IntAct=EBI-298152, EBI-401755; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Cell projection, ruffle (By similarity). Note=Colocalizes with F- actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase. TISSUE SPECIFICITY: Widely expressed in fetal and adult tissues. DOMAIN: The Pro-rich domain may mediate binding to SH3 domains. DOMAIN: Potential homodimerization is mediated by the coiled coil domain. PTM: Phosphorylated on tyrosine residues; probably by c-Abl, Fyn and c-Src. DISEASE: Defects in CD2AP are the cause of susceptibility to focal segmental glomerulosclerosis type 3 (FSGS3) [MIM:607832]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. SIMILARITY: Contains 3 SH3 domains. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CD2AP";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y5K6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
