ID:CD3G_HUMAN DESCRIPTION: RecName: Full=T-cell surface glycoprotein CD3 gamma chain; AltName: Full=T-cell receptor T3 gamma chain; AltName: CD_antigen=CD3g; Flags: Precursor; FUNCTION: The CD3 complex mediates signal transduction. SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DOMAIN: A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes. SIMILARITY: Contains 1 Ig-like (immunoglobulin-like) domain. SIMILARITY: Contains 1 ITAM domain. WEB RESOURCE: Name=CD3Gbase; Note=CD3G mutation db; URL="http://bioinf.uta.fi/CD3Gbase/"; WEB RESOURCE: Name=Wikipedia; Note=CD3 receptor entry; URL="http://en.wikipedia.org/wiki/CD3_receptor";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09693
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004888 transmembrane signaling receptor activity GO:0030159 receptor signaling complex scaffold activity GO:0042608 T cell receptor binding GO:0042803 protein homodimerization activity GO:0046982 protein heterodimerization activity
Biological Process: GO:0002250 adaptive immune response GO:0002376 immune system process GO:0007163 establishment or maintenance of cell polarity GO:0007166 cell surface receptor signaling pathway GO:0015031 protein transport GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0042110 T cell activation GO:0050776 regulation of immune response GO:0050852 T cell receptor signaling pathway GO:0051260 protein homooligomerization GO:0061024 membrane organization GO:0065003 macromolecular complex assembly GO:0070228 regulation of lymphocyte apoptotic process
Cellular Component: GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0030665 clathrin-coated vesicle membrane GO:0042101 T cell receptor complex GO:0042105 alpha-beta T cell receptor complex
Descriptions from all associated GenBank mRNAs
AK299997 - Homo sapiens cDNA FLJ51080 complete cds, moderately similar to T-cell surface glycoprotein CD3 gamma chain precursor. AK313966 - Homo sapiens cDNA, FLJ94613, Homo sapiens CD3G antigen, gamma polypeptide (TiT3 complex) (CD3G),mRNA. JD470112 - Sequence 451136 from Patent EP1572962. AK315895 - Homo sapiens cDNA, FLJ79544 complete cds, highly similar to T-cell surface glycoprotein CD3 gamma chainprecursor. AK310622 - Homo sapiens cDNA, FLJ17664. X60492 - Human mRNA for CD3-gamma, with 17 bp deletion associated with T-cell receptor immunodeficiency. BC069685 - Homo sapiens cDNA clone IMAGE:7262517, containing frame-shift errors. X04145 - Human mRNA for T-cell receptor T3 gamma polypeptide. AK223314 - Homo sapiens mRNA for CD3G gamma precursor variant, clone: TMS06008. AK310578 - Homo sapiens cDNA, FLJ17620. JD141202 - Sequence 122226 from Patent EP1572962. BC113830 - Homo sapiens CD3g molecule, gamma (CD3-TCR complex), mRNA (cDNA clone MGC:138597 IMAGE:40029587), complete cds. KJ890851 - Synthetic construct Homo sapiens clone ccsbBroadEn_00245 CD3G gene, encodes complete protein. JD311122 - Sequence 292146 from Patent EP1572962. JD147485 - Sequence 128509 from Patent EP1572962. JD176036 - Sequence 157060 from Patent EP1572962. JD431876 - Sequence 412900 from Patent EP1572962. JD254674 - Sequence 235698 from Patent EP1572962. MA869004 - JP 2018536436-A/840: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869005 - JP 2018536436-A/841: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869006 - JP 2018536436-A/842: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869007 - JP 2018536436-A/843: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869008 - JP 2018536436-A/844: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869009 - JP 2018536436-A/845: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869010 - JP 2018536436-A/846: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869011 - JP 2018536436-A/847: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869012 - JP 2018536436-A/848: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869013 - JP 2018536436-A/849: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869014 - JP 2018536436-A/850: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869015 - JP 2018536436-A/851: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869016 - JP 2018536436-A/852: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869017 - JP 2018536436-A/853: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869018 - JP 2018536436-A/854: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869033 - JP 2018536436-A/869: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869034 - JP 2018536436-A/870: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869035 - JP 2018536436-A/871: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869039 - JP 2018536436-A/875: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA878205 - JP 2018536436-A/10041: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869040 - JP 2018536436-A/876: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA878204 - JP 2018536436-A/10040: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869041 - JP 2018536436-A/877: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869042 - JP 2018536436-A/878: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869043 - JP 2018536436-A/879: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869044 - JP 2018536436-A/880: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869045 - JP 2018536436-A/881: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869049 - JP 2018536436-A/885: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869050 - JP 2018536436-A/886: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869051 - JP 2018536436-A/887: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA878198 - JP 2018536436-A/10034: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869052 - JP 2018536436-A/888: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA878196 - JP 2018536436-A/10032: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869063 - JP 2018536436-A/899: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869064 - JP 2018536436-A/900: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869065 - JP 2018536436-A/901: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869066 - JP 2018536436-A/902: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA878200 - JP 2018536436-A/10036: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869067 - JP 2018536436-A/903: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA878201 - JP 2018536436-A/10037: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869068 - JP 2018536436-A/904: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869069 - JP 2018536436-A/905: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA878197 - JP 2018536436-A/10033: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869070 - JP 2018536436-A/906: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869078 - JP 2018536436-A/914: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869079 - JP 2018536436-A/915: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869080 - JP 2018536436-A/916: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869081 - JP 2018536436-A/917: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869087 - JP 2018536436-A/923: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869088 - JP 2018536436-A/924: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869089 - JP 2018536436-A/925: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869090 - JP 2018536436-A/926: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869091 - JP 2018536436-A/927: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869092 - JP 2018536436-A/928: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869093 - JP 2018536436-A/929: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869104 - JP 2018536436-A/940: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869105 - JP 2018536436-A/941: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869106 - JP 2018536436-A/942: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869107 - JP 2018536436-A/943: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869108 - JP 2018536436-A/944: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869109 - JP 2018536436-A/945: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869110 - JP 2018536436-A/946: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869111 - JP 2018536436-A/947: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869112 - JP 2018536436-A/948: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869113 - JP 2018536436-A/949: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869114 - JP 2018536436-A/950: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA869115 - JP 2018536436-A/951: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MP231162 - Sequence 186 from Patent EP3512950. LY600617 - KR 1020180133840-A/10779: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600616 - KR 1020180133840-A/10778: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600610 - KR 1020180133840-A/10772: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600608 - KR 1020180133840-A/10770: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600612 - KR 1020180133840-A/10774: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600613 - KR 1020180133840-A/10775: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600609 - KR 1020180133840-A/10771: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591416 - KR 1020180133840-A/840: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591417 - KR 1020180133840-A/841: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591418 - KR 1020180133840-A/842: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591419 - KR 1020180133840-A/843: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591420 - KR 1020180133840-A/844: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591421 - KR 1020180133840-A/845: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591422 - KR 1020180133840-A/846: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591423 - KR 1020180133840-A/847: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591424 - KR 1020180133840-A/848: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591425 - KR 1020180133840-A/849: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591426 - KR 1020180133840-A/850: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591427 - KR 1020180133840-A/851: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591428 - KR 1020180133840-A/852: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591429 - KR 1020180133840-A/853: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591430 - KR 1020180133840-A/854: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591445 - KR 1020180133840-A/869: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591446 - KR 1020180133840-A/870: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591447 - KR 1020180133840-A/871: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591451 - KR 1020180133840-A/875: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591452 - KR 1020180133840-A/876: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591453 - KR 1020180133840-A/877: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591454 - KR 1020180133840-A/878: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591455 - KR 1020180133840-A/879: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591456 - KR 1020180133840-A/880: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591457 - KR 1020180133840-A/881: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591461 - KR 1020180133840-A/885: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591462 - KR 1020180133840-A/886: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591463 - KR 1020180133840-A/887: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591464 - KR 1020180133840-A/888: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591475 - KR 1020180133840-A/899: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591476 - KR 1020180133840-A/900: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591477 - KR 1020180133840-A/901: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591478 - KR 1020180133840-A/902: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591479 - KR 1020180133840-A/903: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591480 - KR 1020180133840-A/904: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591481 - KR 1020180133840-A/905: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591482 - KR 1020180133840-A/906: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591490 - KR 1020180133840-A/914: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591491 - KR 1020180133840-A/915: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591492 - KR 1020180133840-A/916: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591493 - KR 1020180133840-A/917: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591499 - KR 1020180133840-A/923: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591500 - KR 1020180133840-A/924: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591501 - KR 1020180133840-A/925: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591502 - KR 1020180133840-A/926: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591503 - KR 1020180133840-A/927: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591504 - KR 1020180133840-A/928: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591505 - KR 1020180133840-A/929: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591516 - KR 1020180133840-A/940: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591517 - KR 1020180133840-A/941: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591518 - KR 1020180133840-A/942: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591519 - KR 1020180133840-A/943: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591520 - KR 1020180133840-A/944: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591521 - KR 1020180133840-A/945: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591522 - KR 1020180133840-A/946: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591523 - KR 1020180133840-A/947: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591524 - KR 1020180133840-A/948: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591525 - KR 1020180133840-A/949: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591526 - KR 1020180133840-A/950: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY591527 - KR 1020180133840-A/951: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_tcrPathway - T Cell Receptor Signaling Pathway h_tob1Pathway - Role of Tob in T-cell activation h_thelperPathway - T Helper Cell Surface Molecules h_CSKPathway - Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor h_ctla4Pathway - The Co-Stimulatory Signal During T-cell Activation h_ctlPathway - CTL mediated immune response against target cells h_tcytotoxicPathway - T Cytotoxic Cell Surface Molecules h_tcraPathway - Lck and Fyn tyrosine kinases in initiation of TCR Activation h_tcapoptosisPathway - HIV Induced T Cell Apoptosis h_stathminPathway - Stathmin and breast cancer resistance to antimicrotubule agents h_IL12Pathway - IL12 and Stat4 Dependent Signaling Pathway in Th1 Development h_no2il12Pathway - NO2-dependent IL 12 Pathway in NK cells h_il17Pathway - IL 17 Signaling Pathway h_tcrmolecule - T Cell Receptor and CD3 Complex
Reactome (by CSHL, EBI, and GO)
Protein P09693 (Reactome details) participates in the following event(s):
R-HSA-8850326 TCR binds self-lipid-based antigen via CD1 R-HSA-8850356 TCR binds microbial lipid-based antigen via CD1 R-HSA-2029455 Cross-linking of FCGRIA with IgG-coated Ag R-HSA-8866277 AP-2 directly binds some endocytic cargo R-HSA-198955 TCR complex interacts with peptide antigen-presenting MHC Class I R-HSA-202214 Dephosphorylation of Lck-pY505 by CD45 R-HSA-202233 Inactivation of Lck by Csk R-HSA-202291 Activation of Lck R-HSA-8852200 Inactivation of LCK by PTPN22 R-HSA-202165 Phosphorylation of ITAM motifs in CD3 complexes R-HSA-2029457 Cross-linking of FCGRIIIA with IgG-coated Ag R-HSA-202344 Recruitment of ZAP-70 to phosphorylated ITAMs R-HSA-389758 Dephosphorylation of CD3-zeta by PD-1 bound phosphatases R-HSA-202168 Phosphorylation of ZAP-70 by Lck R-HSA-202307 Change of PKC theta conformation R-HSA-8867756 CLASP proteins and cargo are recruited to the nascent clathrin-coated pit R-HSA-202174 Activation of ZAP-70 R-HSA-8855381 PTPN22 dephosphorylates ZAP70 R-HSA-2029452 Recruitment of SYK to phosphorylated ITAMs R-HSA-8868071 Clathrin recruits PIK3C2A R-HSA-8868661 Dynamin-mediated GTP hydrolysis promotes vesicle scission R-HSA-8868648 SYNJ hydrolyze PI(4,5)P2 to PI(4)P R-HSA-202216 Phosphorylation of SLP-76 R-HSA-202245 Phosphorylation of TBSMs in LAT R-HSA-2029449 Phosphorylation of SYK by Src kinases R-HSA-2029270 Recruitment of PLCgamma to membrane R-HSA-2029273 PI3K binds to p-6Y-SYK R-HSA-2029458 Recruitment of VAV1 to p-6Y-SYK R-HSA-2197697 Recruitment of CRKII:DOCK180:ELMO complex to FCGR R-HSA-2029272 Release of PLCG from FCGR R-HSA-8871194 RAB5 and GAPVD1 bind AP-2 R-HSA-8868658 HSPA8-mediated ATP hydrolysis promotes vesicle uncoating R-HSA-8868659 Clathrin recruits auxilins to the clathrin-coated vesicle R-HSA-8868660 Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle R-HSA-8867754 F- and N- BAR domain proteins bind the clathrin-coated pit R-HSA-8868230 SNX9 recruits components of the actin polymerizing machinery R-HSA-202248 Phosphorylation of PLC-gamma1 R-HSA-2029453 Phosphorylation of VAV R-HSA-2029268 Phosphorylation and activation of PLCG R-HSA-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 R-HSA-8868236 BAR domain proteins recruit dynamin R-HSA-2029467 Activation of RAC1 by CRKII:DOCK180:ELMO R-HSA-2029451 Activation of RAC1 by VAV R-HSA-2029271 PI3K phosphorylates PIP2 to PIP3 R-HSA-8868651 Endophilins recruit synaptojanins to the clathrin-coated pit R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-2029481 FCGR activation R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains R-HSA-1280218 Adaptive Immune System R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-202430 Translocation of ZAP-70 to Immunological synapse R-HSA-389948 PD-1 signaling R-HSA-202403 TCR signaling R-HSA-202424 Downstream TCR signaling R-HSA-168256 Immune System R-HSA-168249 Innate Immune System R-HSA-199991 Membrane Trafficking R-HSA-388841 Costimulation by the CD28 family R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-5653656 Vesicle-mediated transport R-HSA-202433 Generation of second messenger molecules R-HSA-2029485 Role of phospholipids in phagocytosis
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
