ID:TNR5_HUMAN DESCRIPTION: RecName: Full=Tumor necrosis factor receptor superfamily member 5; AltName: Full=B-cell surface antigen CD40; AltName: Full=Bp50; AltName: Full=CD40L receptor; AltName: Full=CDw40; AltName: CD_antigen=CD40; Flags: Precursor; FUNCTION: Receptor for TNFSF5/CD40LG. SUBUNIT: Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. INTERACTION: Q13114:TRAF3; NbExp=3; IntAct=EBI-525714, EBI-357631; Q9Y4K3:TRAF6; NbExp=2; IntAct=EBI-525714, EBI-359276; SUBCELLULAR LOCATION: Isoform I: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform II: Secreted. TISSUE SPECIFICITY: B-cells and in primary carcinomas. DISEASE: Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3) [MIM:606843]. A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections. SIMILARITY: Contains 4 TNFR-Cys repeats. WEB RESOURCE: Name=CD40base; Note=CD40 mutation db; URL="http://bioinf.uta.fi/CD40base/"; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CD40"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/tnfrsf5/"; WEB RESOURCE: Name=Wikipedia; Note=CD40 entry; URL="http://en.wikipedia.org/wiki/CD40";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P25942
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003823 antigen binding GO:0004871 signal transducer activity GO:0005031 tumor necrosis factor-activated receptor activity GO:0005515 protein binding GO:0019899 enzyme binding GO:0019904 protein domain specific binding GO:0031625 ubiquitin protein ligase binding GO:0038023 signaling receptor activity
Biological Process: GO:0001934 positive regulation of protein phosphorylation GO:0002376 immune system process GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006874 cellular calcium ion homeostasis GO:0006954 inflammatory response GO:0006955 immune response GO:0007275 multicellular organism development GO:0009617 response to bacterium GO:0030168 platelet activation GO:0030890 positive regulation of B cell proliferation GO:0031667 response to nutrient levels GO:0032496 response to lipopolysaccharide GO:0032735 positive regulation of interleukin-12 production GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0033590 response to cobalamin GO:0034341 response to interferon-gamma GO:0036018 cellular response to erythropoietin GO:0042100 B cell proliferation GO:0042113 B cell activation GO:0042127 regulation of cell proliferation GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042832 defense response to protozoan GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043406 positive regulation of MAP kinase activity GO:0043491 protein kinase B signaling GO:0043536 positive regulation of blood vessel endothelial cell migration GO:0043547 positive regulation of GTPase activity GO:0045766 positive regulation of angiogenesis GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048304 positive regulation of isotype switching to IgG isotypes GO:0050776 regulation of immune response GO:0051023 regulation of immunoglobulin secretion GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051607 defense response to virus GO:0065003 macromolecular complex assembly GO:0071222 cellular response to lipopolysaccharide GO:0071260 cellular response to mechanical stimulus GO:0071347 cellular response to interleukin-1 GO:0071356 cellular response to tumor necrosis factor GO:0090037 positive regulation of protein kinase C signaling GO:0097190 apoptotic signaling pathway GO:1901652 response to peptide GO:2000353 positive regulation of endothelial cell apoptotic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
