Human Gene CD59 (ENST00000642928.2_7) from GENCODE V47lift37
  Description: CD59 molecule (CD59 blood group), transcript variant 2 (from RefSeq NM_000611.6)
Gencode Transcript: ENST00000642928.2_7
Gencode Gene: ENSG00000085063.18_17
Transcript (Including UTRs)
   Position: hg19 chr11:33,724,556-33,757,969 Size: 33,414 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr11:33,731,672-33,743,991 Size: 12,320 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:33,724,556-33,757,969)mRNA (may differ from genome)Protein (128 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CD59
Diseases sorted by gene-association score: hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy* (1650), hemolytic anemia (36), hemoglobinuria (32), paroxysmal nocturnal hemoglobinuria (29), autoimmune hemolytic anemia (28), polyneuropathy (18), aplastic anemia (14), multiple congenital anomalies-hypotonia-seizures syndrome 2 (11), parametritis (10), budd-chiari syndrome (9), multiple congenital anomalies-hypotonia-seizures syndrome 1 (9), primary amebic meningoencephalitis (8), laryngeal tuberculosis (7), retinitis pigmentosa 27 (7), neuromyelitis optica (7), pick disease (6), lymphopenia (6), multiple congenital anomalies-hypotonia-seizures syndrome 3 (6), functional colonic disease (6), red-green color blindness (5), colonic pseudo-obstruction (5), pituitary-dependent cushing's disease (4), tricuspid valve stenosis (4), myelodysplastic syndrome (2), macular degeneration, age-related, 1 (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C023036 perfluorooctanoic acid
  • D001564 Benzo(a)pyrene
  • D005038 Ethylnitrosourea
  • D008748 Methylcholanthrene
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • D015081 2-Naphthylamine
  • C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone
  • D015112 4-Nitroquinoline-1-oxide
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.7060-0.278 Picture PostScript Text
3' UTR -2310.407116-0.325 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018363 - CD59_antigen_CS
IPR016054 - LY6_UPA_recep-like
IPR001526 - LY6_UPAR

Pfam Domains:
PF00021 - u-PAR/Ly-6 domain

SCOP Domains:
57302 - Snake toxin-like

ModBase Predicted Comparative 3D Structure on Q6FHM9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0001971 negative regulation of activation of membrane attack complex


-  Descriptions from all associated GenBank mRNAs
  BC033226 - Homo sapiens CD59 molecule, complement regulatory protein, mRNA (cDNA clone IMAGE:5088648), with apparent retained intron.
AL080087 - Homo sapiens mRNA; cDNA DKFZp564K1662 (from clone DKFZp564K1662).
AL049957 - Homo sapiens mRNA; cDNA DKFZp564J0323 (from clone DKFZp564J0323).
BC050619 - Homo sapiens H2A histone family, member Z, mRNA (cDNA clone IMAGE:5549442), **** WARNING: chimeric clone ****.
BC001506 - Homo sapiens CD59 molecule, complement regulatory protein, mRNA (cDNA clone MGC:2354 IMAGE:2988140), complete cds.
JD292074 - Sequence 273098 from Patent EP1572962.
JD550483 - Sequence 531507 from Patent EP1572962.
E02823 - cDNA encoding surface antigen of human lymphocyte.
AK128571 - Homo sapiens cDNA FLJ46730 fis, clone TRACH3019598.
M34671 - Human lymphocytic antigen CD59/MEM43 mRNA, complete cds.
JD327853 - Sequence 308877 from Patent EP1572962.
JD281220 - Sequence 262244 from Patent EP1572962.
JD403707 - Sequence 384731 from Patent EP1572962.
X84805 - H.sapiens mRNA for IL-1/TNF inducible EST (clone MEC-205).
JD324357 - Sequence 305381 from Patent EP1572962.
JD454611 - Sequence 435635 from Patent EP1572962.
JD250832 - Sequence 231856 from Patent EP1572962.
JD056048 - Sequence 37072 from Patent EP1572962.
JD454143 - Sequence 435167 from Patent EP1572962.
JD503193 - Sequence 484217 from Patent EP1572962.
JD417791 - Sequence 398815 from Patent EP1572962.
JD114692 - Sequence 95716 from Patent EP1572962.
JD202230 - Sequence 183254 from Patent EP1572962.
JD225555 - Sequence 206579 from Patent EP1572962.
E02822 - cDNA encoding surface antigen of human lymphocyte.
X16447 - Human mRNA for CD59, an LY-6-like protein regulating complement membrane attack.
JD153424 - Sequence 134448 from Patent EP1572962.
JD094586 - Sequence 75610 from Patent EP1572962.
JD546763 - Sequence 527787 from Patent EP1572962.
AK309894 - Homo sapiens cDNA, FLJ99935.
JD319784 - Sequence 300808 from Patent EP1572962.
JD154178 - Sequence 135202 from Patent EP1572962.
JD151566 - Sequence 132590 from Patent EP1572962.
JD092181 - Sequence 73205 from Patent EP1572962.
JD059027 - Sequence 40051 from Patent EP1572962.
JD101545 - Sequence 82569 from Patent EP1572962.
JD485065 - Sequence 466089 from Patent EP1572962.
M27909 - Homo sapiens T cell-activating protein (HRF20) mRNA, complete cds.
M95708 - Homo sapiens Ly-6-like protein (CD59) mRNA, complete cds.
E03075 - cDNA sequence coding for human membrane attack complex inhibitor factor.
E02764 - DNA encoding human lymphocyte surface antigen.
X17198 - Human mRNA for CD59 antigen.
DQ890640 - Synthetic construct clone IMAGE:100003270; FLH164691.01X; RZPDo839A10158D CD59 molecule, complement regulatory protein (CD59) gene, encodes complete protein.
CR541722 - Homo sapiens full open reading frame cDNA clone RZPDo834D0829D for gene CD59, CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344); complete cds, incl. stopcodon.
E02686 - cDNA encoding IF5 antigen protein which inhibits complement-mediated cell membrane damage.
AK311778 - Homo sapiens cDNA, FLJ92039, Homo sapiens CD59 antigen p18-20 (antigen identified by monoclonalantibodies 16.3A5, EJ16, EJ30, EL32 and G344) (CD59), mRNA.
BT007104 - Homo sapiens CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) mRNA, complete cds.
KJ890868 - Synthetic construct Homo sapiens clone ccsbBroadEn_00262 CD59 gene, encodes complete protein.
AB528318 - Synthetic construct DNA, clone: pF1KB3692, Homo sapiens CD59 gene for CD59 molecule, complement regulatory protein, without stop codon, in Flexi system.
CR407661 - Homo sapiens full open reading frame cDNA clone RZPDo834A033D for gene CD59, CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) complete cds, without stopcodon.
DQ893818 - Synthetic construct Homo sapiens clone IMAGE:100008278; FLH164687.01L; RZPDo839A10157D CD59 molecule, complement regulatory protein (CD59) gene, encodes complete protein.
EU176474 - Synthetic construct Homo sapiens clone IMAGE:100011649; FLH264069.01L; RZPDo839E11257D CD59 molecule, complement regulatory protein (CD59) gene, encodes complete protein.
CU674742 - Synthetic construct Homo sapiens gateway clone IMAGE:100018529 5' read CD59 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: CD59 , ENST00000642928.1, hCG_2033390 , NM_000611, Q6FHM9, Q6FHM9_HUMAN, uc328jdy.1, uc328jdy.2
UCSC ID: ENST00000642928.2_7
RefSeq Accession: NM_000611.6
Protein: Q6FHM9

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.