ID:CD8A_HUMAN DESCRIPTION: RecName: Full=T-cell surface glycoprotein CD8 alpha chain; AltName: Full=T-lymphocyte differentiation antigen T8/Leu-2; AltName: CD_antigen=CD8a; Flags: Precursor; FUNCTION: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. SUBUNIT: In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 2: Secreted. PTM: All of the five most C-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N- terminal cysteines do not (By similarity). DISEASE: Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. WEB RESOURCE: Name=CD8Abase; Note=CD8A mutation db; URL="http://bioinf.uta.fi/CD8Abase/"; WEB RESOURCE: Name=Wikipedia; Note=CD8 entry; URL="http://en.wikipedia.org/wiki/CD8";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P01732
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK124156 - Homo sapiens cDNA FLJ42162 fis, clone THYMU2005303, highly similar to T-CELL SURFACE GLYCOPROTEIN CD8 ALPHA CHAIN PRECURSOR. BC025715 - Homo sapiens CD8a molecule, mRNA (cDNA clone MGC:34614 IMAGE:5227906), complete cds. AK097942 - Homo sapiens cDNA FLJ40623 fis, clone THYMU2013863, highly similar to T-cell surface glycoprotein CD8 alpha chain precursor. LP880230 - Sequence 34 from Patent WO2017181111. LP882059 - Sequence 1 from Patent WO2017181079. LQ882852 - Sequence 1 from Patent WO2018160841. M12824 - Human T-cell differentiation antigen Leu-2/T8 mRNA, partial cds. JD098300 - Sequence 79324 from Patent EP1572962. JD531124 - Sequence 512148 from Patent EP1572962. JD575757 - Sequence 81 from Patent EP2831104. JD171039 - Sequence 152063 from Patent EP1572962. JD275058 - Sequence 256082 from Patent EP1572962. JD240179 - Sequence 221203 from Patent EP1572962. JD049825 - Sequence 30849 from Patent EP1572962. JD117575 - Sequence 98599 from Patent EP1572962. JD472775 - Sequence 453799 from Patent EP1572962. JD038488 - Sequence 19512 from Patent EP1572962. JD365521 - Sequence 346545 from Patent EP1572962. M12828 - Homo sapiens T-cell surface protein T8 mRNA. JD049769 - Sequence 30793 from Patent EP1572962. JD300464 - Sequence 281488 from Patent EP1572962. AY039664 - Homo sapiens mutant CD8 alpha antigen (CD8A) mRNA, complete cds. AK300089 - Homo sapiens cDNA FLJ61164 complete cds, highly similar to T-cell surface glycoprotein CD8 alpha chain precursor. JD164311 - Sequence 145335 from Patent EP1572962. JD308545 - Sequence 289569 from Patent EP1572962. DQ893323 - Synthetic construct clone IMAGE:100005953; FLH196164.01X; RZPDo839E06154D CD8a molecule (CD8A) gene, encodes complete protein. DQ896638 - Synthetic construct Homo sapiens clone IMAGE:100011098; FLH196160.01L; RZPDo839E06153D CD8a molecule (CD8A) gene, encodes complete protein. DQ896639 - Synthetic construct Homo sapiens clone IMAGE:100011099; FLH263665.01L; RZPDo839E07153D CD8a molecule (CD8A) gene, encodes complete protein. LQ927224 - Sequence 1 from Patent WO2018191660. MP202732 - Sequence 43 from Patent WO2019090263. MB143790 - JP 2019515670-A/1: METHODS FOR MONITORING AND TREATING CANCER. MB423114 - JP 2019521641-A/1: METHODS FOR MONITORING AND TREATING CANCER. MP584502 - Sequence 1 from Patent WO2020081767.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_tcytotoxicPathway - T Cytotoxic Cell Surface Molecules h_il17Pathway - IL 17 Signaling Pathway h_stemPathway - Regulation of hematopoiesis by cytokines
Reactome (by CSHL, EBI, and GO)
Protein P01732 (Reactome details) participates in the following event(s):
R-HSA-198955 TCR complex interacts with peptide antigen-presenting MHC Class I R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
