Human Gene CDA (ENST00000375071.4_4) from GENCODE V47lift37
  Description: cytidine deaminase (from RefSeq NM_001785.3)
Gencode Transcript: ENST00000375071.4_4
Gencode Gene: ENSG00000158825.6_7
Transcript (Including UTRs)
   Position: hg19 chr1:20,915,590-20,945,396 Size: 29,807 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr1:20,915,623-20,945,061 Size: 29,439 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:20,915,590-20,945,396)mRNA (may differ from genome)Protein (146 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CDD_HUMAN
DESCRIPTION: RecName: Full=Cytidine deaminase; EC=3.5.4.5; AltName: Full=Cytidine aminohydrolase;
FUNCTION: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
CATALYTIC ACTIVITY: Cytidine + H(2)O = uridine + NH(3).
COFACTOR: Zinc.
SUBUNIT: Homotetramer.
TISSUE SPECIFICITY: Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines.
SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CDA
Diseases sorted by gene-association score: refractory hematologic cancer (10), xeroderma pigmentosum, group d (9), refractory hairy cell leukemia (8), central nervous system leukemia (6), immunodeficiency with hyper-igm, type 2 (5), hematologic cancer (2), leukemia, acute myeloid (0)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 177.28 RPKM in Whole Blood
Total median expression: 451.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.1033-0.215 Picture PostScript Text
3' UTR -89.20335-0.266 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016192 - APOBEC/CMP_deaminase_Zn-bd
IPR002125 - CMP_dCMP_Zn-bd
IPR006262 - Cyt_deam_tetra
IPR016193 - Cytidine_deaminase-like

Pfam Domains:
PF00383 - Cytidine and deoxycytidylate deaminase zinc-binding region
PF08211 - Cytidine and deoxycytidylate deaminase zinc-binding region

SCOP Domains:
53927 - Cytidine deaminase-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1MQ0 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P32320
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene Details  Gene DetailsGene DetailsGene Details
Gene Sorter  Gene SorterGene SorterGene Sorter
  Ensembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001882 nucleoside binding
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding

Biological Process:
GO:0007166 cell surface receptor signaling pathway
GO:0008655 pyrimidine-containing compound salvage
GO:0009972 cytidine deamination
GO:0019858 cytosine metabolic process
GO:0030308 negative regulation of cell growth
GO:0043097 pyrimidine nucleoside salvage
GO:0043312 neutrophil degranulation
GO:0045980 negative regulation of nucleotide metabolic process
GO:0051289 protein homotetramerization

Cellular Component:
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0034774 secretory granule lumen
GO:1904724 tertiary granule lumen
GO:1904813 ficolin-1-rich granule lumen


-  Descriptions from all associated GenBank mRNAs
  BC048284 - Homo sapiens cytidine deaminase, mRNA (cDNA clone IMAGE:5213873).
AY634312 - Homo sapiens small cytidine deaminase mRNA, complete cds.
L27943 - Homo sapiens cytidine deaminase (CDA) mRNA, complete cds.
BC054036 - Homo sapiens cytidine deaminase, mRNA (cDNA clone MGC:64975 IMAGE:5403243), complete cds.
JD423790 - Sequence 404814 from Patent EP1572962.
JD271957 - Sequence 252981 from Patent EP1572962.
JD409047 - Sequence 390071 from Patent EP1572962.
AJ000474 - Homo sapiens mRNA for cytidine deaminase.
CU691080 - Synthetic construct Homo sapiens gateway clone IMAGE:100021573 5' read CDA mRNA.
HQ448573 - Synthetic construct Homo sapiens clone IMAGE:100072011; CCSB011943_01 cytidine deaminase (CDA) gene, encodes complete protein.
KJ896574 - Synthetic construct Homo sapiens clone ccsbBroadEn_05968 CDA gene, encodes complete protein.
KR711098 - Synthetic construct Homo sapiens clone CCSBHm_00020221 CDA (CDA) mRNA, encodes complete protein.
S52873 - cytidine deaminase [human, monocytoid cell line U937, mRNA Partial, 736 nt].
JD081161 - Sequence 62185 from Patent EP1572962.
JD535350 - Sequence 516374 from Patent EP1572962.
JD537240 - Sequence 518264 from Patent EP1572962.
JD309056 - Sequence 290080 from Patent EP1572962.
JD183241 - Sequence 164265 from Patent EP1572962.
JD297434 - Sequence 278458 from Patent EP1572962.
JD554106 - Sequence 535130 from Patent EP1572962.
JD382855 - Sequence 363879 from Patent EP1572962.
JD392741 - Sequence 373765 from Patent EP1572962.
JD270648 - Sequence 251672 from Patent EP1572962.
JD100147 - Sequence 81171 from Patent EP1572962.
JD256217 - Sequence 237241 from Patent EP1572962.
JD243440 - Sequence 224464 from Patent EP1572962.
JD514288 - Sequence 495312 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-7181 - pyrimidine deoxyribonucleosides degradation
PWY-7193 - pyrimidine ribonucleosides salvage I
PWY-7199 - pyrimidine deoxyribonucleosides salvage
PWY-7200 - superpathway of pyrimidine deoxyribonucleoside salvage
PWY-7209 - superpathway of pyrimidine ribonucleosides degradation
PWY0-1295 - pyrimidine ribonucleosides degradation

Reactome (by CSHL, EBI, and GO)

Protein P32320 (Reactome details) participates in the following event(s):

R-HSA-6798745 Exocytosis of tertiary granule lumen proteins
R-HSA-6798748 Exocytosis of secretory granule lumen proteins
R-HSA-6800434 Exocytosis of ficolin-rich granule lumen proteins
R-HSA-73608 (deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)
R-HSA-6798695 Neutrophil degranulation
R-HSA-73614 Pyrimidine salvage
R-HSA-168249 Innate Immune System
R-HSA-8956321 Nucleotide salvage
R-HSA-168256 Immune System
R-HSA-15869 Metabolism of nucleotides
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: CDA , CDD, CDD_HUMAN, ENST00000375071.1, ENST00000375071.2, ENST00000375071.3, NM_001785, P32320, uc318mal.1, uc318mal.2
UCSC ID: ENST00000375071.4_4
RefSeq Accession: NM_001785.3
Protein: P32320 (aka CDD_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.