ID:CDC20_HUMAN DESCRIPTION: RecName: Full=Cell division cycle protein 20 homolog; AltName: Full=p55CDC; FUNCTION: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with SPATC1. Interacts with NEUROD2 (By similarity). Interacts with MAD2L1 and BUB1B. The phosphorylated form interacts with APC/C. Interacts with NINL. May interact with MAD2L2. Interacts with CDK5RAP2. Interacts with isoform 1 of NEK2. INTERACTION: O60566:BUB1B; NbExp=8; IntAct=EBI-367462, EBI-1001438; P30260:CDC27; NbExp=6; IntAct=EBI-367462, EBI-994813; Q13257:MAD2L1; NbExp=5; IntAct=EBI-367462, EBI-78203; Q9UI95:MAD2L2; NbExp=2; IntAct=EBI-367462, EBI-77889; Q9NS23-2:RASSF1; NbExp=2; IntAct=EBI-367462, EBI-438698; Q8IXJ6-2:SIRT2; NbExp=2; IntAct=EBI-367462, EBI-5240785; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. DEVELOPMENTAL STAGE: Synthesis is initiated at G1/S, protein level peaks in M phase and protein is abruptly degraded at M/G1 transition. PTM: Phosphorylated during mitosis, probably by maturation promoting factor (MPF). Phosphorylated by BUB1 at Ser-41; Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161. Phosphorylated by NEK2. PTM: Dephosphorylated by CTDP1. PTM: Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint. Deubiquitinated by USP44, leading to stabilize the MAD2L1-CDC20-APC/C ternary complex, thereby preventing premature activation of the APC/C. Ubiquitinated at Lys-490 during prometaphase. Ubiquitination at Lys-485 and Lys-490 has no effect on its ability to bind the APC/C completo bind the APC/C complex. SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family. SIMILARITY: Contains 7 WD repeats. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CDC20ID40003ch1p34.html"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdc20/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q12834
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF206584 - JP 2014500723-A/14087: Polycomb-Associated Non-Coding RNAs. AK303844 - Homo sapiens cDNA FLJ51449 complete cds, highly similar to Cell division cycle protein 20 homolog. BC001088 - Homo sapiens cell division cycle 20 homolog (S. cerevisiae), mRNA (cDNA clone MGC:2830 IMAGE:2964686), complete cds. BC012827 - Homo sapiens cell division cycle 20 homolog (S. cerevisiae), mRNA (cDNA clone MGC:4503 IMAGE:2964686), complete cds. AK302539 - Homo sapiens cDNA FLJ59100 complete cds, highly similar to Cell division cycle protein 20 homolog. U05340 - Human p55CDC mRNA, complete cds. BC010044 - Homo sapiens cell division cycle 20 homolog (S. cerevisiae), mRNA (cDNA clone MGC:19761 IMAGE:3634656), complete cds. LF206586 - JP 2014500723-A/14089: Polycomb-Associated Non-Coding RNAs. BC009425 - Homo sapiens cell division cycle 20 homolog (S. cerevisiae), mRNA (cDNA clone MGC:15275 IMAGE:2959460), complete cds. BC009426 - Homo sapiens cell division cycle 20 homolog (S. cerevisiae), mRNA (cDNA clone MGC:15276 IMAGE:2959596), complete cds. BC012803 - Homo sapiens cell division cycle 20 homolog (S. cerevisiae), mRNA (cDNA clone MGC:2777 IMAGE:2959588), complete cds. BC013303 - Homo sapiens cell division cycle 20 homolog (S. cerevisiae), mRNA (cDNA clone MGC:4441 IMAGE:2959588), complete cds. BC024257 - Homo sapiens cell division cycle 20 homolog (S. cerevisiae), mRNA (cDNA clone MGC:15441 IMAGE:2959460), complete cds. BC031294 - Homo sapiens cell division cycle 20 homolog (S. cerevisiae), mRNA (cDNA clone MGC:15304 IMAGE:2959487), complete cds. AK312780 - Homo sapiens cDNA, FLJ93197, highly similar to Homo sapiens CDC20 cell division cycle 20 homolog (S. cerevisiae) (CDC20), mRNA. AK225504 - Homo sapiens mRNA for Cell division cycle protein 20 homolog, clone: KAT01593. BC015998 - Homo sapiens cell division cycle 20 homolog (S. cerevisiae), mRNA (cDNA clone MGC:27217 IMAGE:4306426), complete cds. BC110321 - Homo sapiens cell division cycle 20 homolog (S. cerevisiae), mRNA (cDNA clone MGC:102824 IMAGE:5496957), complete cds. BC000624 - Homo sapiens cell division cycle 20 homolog (S. cerevisiae), mRNA (cDNA clone MGC:3076 IMAGE:3346682), complete cds. BC006272 - Homo sapiens cell division cycle 20 homolog (S. cerevisiae), mRNA (cDNA clone MGC:10620 IMAGE:3948819), complete cds. AF099644 - Homo sapiens cell cycle protein CDC20 mRNA, complete cds. AB590358 - Synthetic construct DNA, clone: pFN21AE1433, Homo sapiens CDC20 gene for cell division cycle 20 homolog, without stop codon, in Flexi system. EU831712 - Synthetic construct Homo sapiens clone HAIB:100066741; DKFZo003D1220 cell division cycle 20 homolog (S. cerevisiae) protein (CDC20) gene, encodes complete protein. DQ892290 - Synthetic construct clone IMAGE:100004920; FLH184914.01X; RZPDo839D03146D CDC20 cell division cycle 20 homolog (S. cerevisiae) (CDC20) gene, encodes complete protein. DQ895489 - Synthetic construct Homo sapiens clone IMAGE:100009949; FLH184910.01L; RZPDo839D03145D CDC20 cell division cycle 20 homolog (S. cerevisiae) (CDC20) gene, encodes complete protein. EU831627 - Synthetic construct Homo sapiens clone HAIB:100066656; DKFZo007D1219 cell division cycle 20 homolog (S. cerevisiae) protein (CDC20) gene, encodes complete protein. CU675321 - Synthetic construct Homo sapiens gateway clone IMAGE:100020310 5' read CDC20 mRNA. CU679585 - Synthetic construct Homo sapiens gateway clone IMAGE:100017371 5' read CDC20 mRNA. CU674302 - Synthetic construct Homo sapiens gateway clone IMAGE:100018353 5' read CDC20 mRNA. KJ890877 - Synthetic construct Homo sapiens clone ccsbBroadEn_00271 CDC20 gene, encodes complete protein. KJ896576 - Synthetic construct Homo sapiens clone ccsbBroadEn_05970 CDC20 gene, encodes complete protein. KJ896577 - Synthetic construct Homo sapiens clone ccsbBroadEn_05971 CDC20 gene, encodes complete protein. BT007388 - Homo sapiens CDC20 cell division cycle 20 homolog (S. cerevisiae) mRNA, complete cds. LF356385 - JP 2014500723-A/163888: Polycomb-Associated Non-Coding RNAs. LF356383 - JP 2014500723-A/163886: Polycomb-Associated Non-Coding RNAs. LF356382 - JP 2014500723-A/163885: Polycomb-Associated Non-Coding RNAs. LF356381 - JP 2014500723-A/163884: Polycomb-Associated Non-Coding RNAs. LF356380 - JP 2014500723-A/163883: Polycomb-Associated Non-Coding RNAs. LF206583 - JP 2014500723-A/14086: Polycomb-Associated Non-Coding RNAs. LF356378 - JP 2014500723-A/163881: Polycomb-Associated Non-Coding RNAs. MA442161 - JP 2018138019-A/14087: Polycomb-Associated Non-Coding RNAs. MA442163 - JP 2018138019-A/14089: Polycomb-Associated Non-Coding RNAs. MA591962 - JP 2018138019-A/163888: Polycomb-Associated Non-Coding RNAs. MA591960 - JP 2018138019-A/163886: Polycomb-Associated Non-Coding RNAs. MA591959 - JP 2018138019-A/163885: Polycomb-Associated Non-Coding RNAs. MA591958 - JP 2018138019-A/163884: Polycomb-Associated Non-Coding RNAs. MA591957 - JP 2018138019-A/163883: Polycomb-Associated Non-Coding RNAs. MA442160 - JP 2018138019-A/14086: Polycomb-Associated Non-Coding RNAs. MA591955 - JP 2018138019-A/163881: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q12834 (Reactome details) participates in the following event(s):
R-HSA-141429 Inactivation of APC/C via CDC20 sequestration R-HSA-141437 Formation of the MCC complex R-HSA-174224 Dissociation of Cdc20 from APC/C complex R-HSA-174235 Association of Emi1 with Cdc20 R-HSA-141423 Binding of the MCC complex to the APC/C complex R-HSA-174120 Association of Cyclin B:Cdc2 with Cdc20:APC/C complex R-HSA-174121 Association of Securin with Cdc20:APC/C complex R-HSA-174238 Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-174088 Association of cell cycle proteins with the APC/C:Cdh1 complex R-HSA-5696958 USP44 deubiquitinates CDC20 R-HSA-174171 Association of Cyclin A with the APC/C R-HSA-179410 Association of Nek2A with MCC:APC/C R-HSA-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex R-HSA-174144 Ubiquitination of Securin by phospho-APC/C:Cdc20 complex R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-174195 Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex R-HSA-174174 Phosphorylation of the Emi1 DSGxxS degron by Plk1 R-HSA-174122 Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 R-HSA-174104 Ubiquitination of Cyclin A by APC/C:Cdc20 complex R-HSA-179417 Multiubiquitination of Nek2A R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-174209 Phosphorylated Emi1 binds the beta-TrCP in the SCF complex R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-174159 Ubiquitination of Emi1 by SCF-beta-TrCP R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin R-HSA-2467813 Separation of Sister Chromatids R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-174143 APC/C-mediated degradation of cell cycle proteins R-HSA-5689880 Ub-specific processing proteases R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A R-HSA-68882 Mitotic Anaphase R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-69620 Cell Cycle Checkpoints R-HSA-453276 Regulation of mitotic cell cycle R-HSA-5688426 Deubiquitination R-HSA-176417 Phosphorylation of Emi1 R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-1640170 Cell Cycle R-HSA-597592 Post-translational protein modification R-HSA-162582 Signal Transduction R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-392499 Metabolism of proteins R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
