ID:CDCA2_HUMAN DESCRIPTION: RecName: Full=Cell division cycle-associated protein 2; AltName: Full=Recruits PP1 onto mitotic chromatin at anaphase protein; Short=Repo-Man; FUNCTION: Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. SUBUNIT: Interacts with PPP1CC. SUBCELLULAR LOCATION: Nucleus. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin. TISSUE SPECIFICITY: Ubiquitously expressed. PTM: Phosphorylated by CDK1. May regulate its subcellular location. SEQUENCE CAUTION: Sequence=AAH36214.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC05374.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAH10577.1; Type=Erroneous translation; Note=Wrong choice of CDS;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF15276 - Protein phosphatase 1 binding
ModBase Predicted Comparative 3D Structure on Q69YH5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
