Human Gene CDCA4 (ENST00000336219.4_7) from GENCODE V47lift37
  Description: cell division cycle associated 4, transcript variant 2 (from RefSeq NM_145701.4)
Gencode Transcript: ENST00000336219.4_7
Gencode Gene: ENSG00000170779.11_9
Transcript (Including UTRs)
   Position: hg19 chr14:105,475,910-105,487,420 Size: 11,511 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr14:105,477,541-105,478,266 Size: 726 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:105,475,910-105,487,420)mRNA (may differ from genome)Protein (241 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CDCA4_HUMAN
DESCRIPTION: RecName: Full=Cell division cycle-associated protein 4; AltName: Full=Hematopoietic progenitor protein;
FUNCTION: May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and heart.
INDUCTION: By E2F1.
SIMILARITY: Contains 1 SERTA domain.
SEQUENCE CAUTION: Sequence=BAA91373.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.13 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 51.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -41.6091-0.457 Picture PostScript Text
3' UTR -496.101631-0.304 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009263 - SERTA

Pfam Domains:
PF06031 - SERTA motif

ModBase Predicted Comparative 3D Structure on Q9BXL8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane


-  Descriptions from all associated GenBank mRNAs
  BC011736 - Homo sapiens cell division cycle associated 4, mRNA (cDNA clone MGC:19517 IMAGE:4335816), complete cds.
AK000771 - Homo sapiens cDNA FLJ20764 fis, clone COL08503.
AF322239 - Homo sapiens hematopoietic progenitor protein (HEPP) mRNA, complete cds.
JD298296 - Sequence 279320 from Patent EP1572962.
JD513690 - Sequence 494714 from Patent EP1572962.
JD220248 - Sequence 201272 from Patent EP1572962.
JD272526 - Sequence 253550 from Patent EP1572962.
JD492527 - Sequence 473551 from Patent EP1572962.
JD487136 - Sequence 468160 from Patent EP1572962.
JD546427 - Sequence 527451 from Patent EP1572962.
JD191498 - Sequence 172522 from Patent EP1572962.
AK303947 - Homo sapiens cDNA FLJ52878 complete cds, highly similar to Cell division cycle-associated protein 4.
JD050507 - Sequence 31531 from Patent EP1572962.
JD169930 - Sequence 150954 from Patent EP1572962.
JD443459 - Sequence 424483 from Patent EP1572962.
JD205821 - Sequence 186845 from Patent EP1572962.
JD468147 - Sequence 449171 from Patent EP1572962.
JD255264 - Sequence 236288 from Patent EP1572962.
JD227206 - Sequence 208230 from Patent EP1572962.
JD090143 - Sequence 71167 from Patent EP1572962.
BC025263 - Homo sapiens cell division cycle associated 4, mRNA (cDNA clone MGC:39154 IMAGE:4860036), complete cds.
JD458244 - Sequence 439268 from Patent EP1572962.
JD540978 - Sequence 522002 from Patent EP1572962.
JD393743 - Sequence 374767 from Patent EP1572962.
JD101045 - Sequence 82069 from Patent EP1572962.
JD373047 - Sequence 354071 from Patent EP1572962.
JD540450 - Sequence 521474 from Patent EP1572962.
CU692948 - Synthetic construct Homo sapiens gateway clone IMAGE:100021848 5' read CDCA4 mRNA.
KJ899067 - Synthetic construct Homo sapiens clone ccsbBroadEn_08461 CDCA4 gene, encodes complete protein.
KJ906213 - Synthetic construct Homo sapiens clone ccsbBroadEn_15883 CDCA4 gene, encodes complete protein.
DQ893408 - Synthetic construct clone IMAGE:100006038; FLH199484.01X; RZPDo839D0482D cell division cycle associated 4 (CDCA4) gene, encodes complete protein.
DQ896726 - Synthetic construct Homo sapiens clone IMAGE:100011186; FLH199390.01L; RZPDo839D0481D cell division cycle associated 4 (CDCA4) gene, encodes complete protein.
AB464477 - Synthetic construct DNA, clone: pF1KB8773, Homo sapiens CDCA4 gene for cell division cycle associated 4, without stop codon, in Flexi system.
JD222841 - Sequence 203865 from Patent EP1572962.
JD521314 - Sequence 502338 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CDCA4_HUMAN, ENST00000336219.1, ENST00000336219.2, ENST00000336219.3, HEPP, NM_145701, Q8TB18, Q9BXL8, Q9NWK7, uc317uly.1, uc317uly.2
UCSC ID: ENST00000336219.4_7
RefSeq Accession: NM_017955.4
Protein: Q9BXL8 (aka CDCA4_HUMAN or CCA4_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.